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anti-FAP antibody :: Rabbit anti-Human Seprase/Fibroblast Activation Protein Alpha (FAP) Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS395833
Immunohistochemistry (IHC)
Unit / Price
  DISCONTINUED
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 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Seprase/Fibroblast Activation Protein Alpha (FAP), Polyclonal Antibody

 Also Known As   

Seprase/Fibroblast Activation Protein Alpha (FAP)

 Product Synonym Names    DKFZP686G13158; DPPIV; EC 3.4.21.-; FAP; FAPA; SEPRASE
 Product Gene Name   

anti-FAP antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 2; NC_000002.11 (163027200..163100045, complement). Location: 2q23
 OMIM    600403
 3D Structure    ModBase 3D Structure for Q12884
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Purity/Purification    Immunoaffinity Purification
 Form/Format    Phosphate buffered saline containing 0.1% sodium azide
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 Immunogen    Extracellular domain of human
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 Preparation and Storage    Product should be stored at -70 degree C. Aliquot to avoid freeze/thaw cycles
 Other Notes    Small volumes of anti-FAP antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-FAP antibody

   May have a role in tissue remodeling during development and wound healing, and may contribute to invasiveness in malignant cancers. Degrades gelatin and heat-denatured type I and type IV collagen, but not native type I or type IV collagen. Does not cleave laminin, fibronectin, fibrin or casein.
 Product Categories/Family for anti-FAP antibody    Antigen Immunoaffinity Purifed Polyclonal; Serine S9
 Applications Tested/Suitable for anti-FAP antibody   

Immunohistochemistry (IHC) Paraffin

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 Immunohistochemistry (IHC) of anti-FAP antibody    FAP staining of formallin fixed paraffin embedded uterus tissue at a dilution of 10 ug/ml. Antigen retrieval using a citrate buffer and steam/heat was utilized.
anti-FAP antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for FAP. It may not necessarily be applicable to this product.
 NCBI GI #    16933540
 NCBI GeneID    2191
 NCBI Accession #    NP_004451.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_004460.2 [Other Products]
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 UniProt Primary Accession #    Q12884 [Other Products]
 UniProt Secondary Accession #    O00199; Q53TP5; Q86Z29; Q99998; Q9UID4 [Other Products]
 UniProt Related Accession #    Q12884 [Other Products]
 Molecular Weight    170 kDa
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 NCBI Official Full Name    seprase
 NCBI Official Synonym Full Names    fibroblast activation protein, alpha
 NCBI Official Symbol    FAP [Similar Products]
 NCBI Official Synonym Symbols   
FAPA; DPPIV
[Similar Products]
 NCBI Protein Information    seprase; integral membrane serine protease; 170 kDa melanoma membrane-bound gelatinase
 UniProt Protein Name    Seprase
 UniProt Synonym Protein Names   
170 kDa melanoma membrane-bound gelatinase; Fibroblast activation protein alpha; Integral membrane serine protease
 Protein Family    Prolyl endopeptidase
 UniProt Gene Name    FAP [Similar Products]
 UniProt Entry Name    SEPR_HUMAN
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 NCBI Summary for FAP    The protein encoded by this gene is a homodimeric integral membrane gelatinase belonging to the serine protease family. It is selectively expressed in reactive stromal fibroblasts of epithelial cancers, granulation tissue of healing wounds, and malignant cells of bone and soft tissue sarcomas. This protein is thought to be involved in the control of fibroblast growth or epithelial-mesenchymal interactions during development, tissue repair, and epithelial carcinogenesis. [provided by RefSeq, Jul 2008]
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 UniProt Comments for FAP    Function: In association with DPP4 is involved in the pericellular proteolysis of the extracellular matrix (ECM), the migration and invasion of endothelial cells into the ECM. May have a role in tissue remodeling during development and wound healing, and may contribute to invasiveness in malignant cancers. Ref.10

Catalytic activity: Degrades gelatin and heat-denatured type I and type IV collagen, but not native type I or type IV collagen. Does not cleave laminin, fibronectin, fibrin or casein.

Subunit structure: Homodimer, or heterodimer with DPP4. The monomer is inactive. Ref.10 Ref.11

Subcellular location: Cell membrane; Single-pass type II membrane protein. Cell projection › lamellipodium membrane; Single-pass type II membrane protein. Cell projection › invadopodium membrane; Single-pass type II membrane protein. Note: Found in cell surface lamellipodia, invadopodia and on shed vesicles. Colocalized with DPP4 in invadopodia and lamellipodia of migratory activated endothelial cells in collagenous matrix. Colocalized with DPP4 on endothelial cells of capillary-like microvessels but not large vessels within invasive breast ductal carcinoma. Ref.10

Tissue specificity: Fibroblast specific.

Induction: In fibroblasts at times and sites of tissue remodeling during development, tissue repair, and carcinogenesis.

Post-translational modification: N-glycosylated. Ref.11The N-terminus may be blocked.

Sequence similarities: Belongs to the peptidase S9B family.
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 Research Articles on FAP    1. High intratumoral expression of fibroblast activation protein is associated with colorectal cancer.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-FAP antibodyDiseases associated with anti-FAP antibody
 Reference Product  PubMed Publications
 DPP4 antibody  >16 publications with FAP and DPP4
 LOX antibody  >2 publications with FAP and LOX
 GIP antibody  >1 publications with FAP and GIP
 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >554 publications with FAP and Carcinoma
 Adenocarcinoma Antibodies  >249 publications with FAP and Adenocarcinoma
 Cardiovascular Diseases Antibodies  >149 publications with FAP and Cardiovascular Diseases
 Hypertrophy Antibodies  >97 publications with FAP and Hypertrophy
 Inflammation Antibodies  >79 publications with FAP and Inflammation
 Thyroid Diseases Antibodies  >66 publications with FAP and Thyroid Diseases
 Precancerous Conditions Antibodies  >43 publications with FAP and Precancerous Conditions
 Necrosis Antibodies  >39 publications with FAP and Necrosis
 Hyperplasia Antibodies  >27 publications with FAP and Hyperplasia
 Weight Loss Antibodies  >21 publications with FAP and Weight Loss
Organs/Tissues associated with anti-FAP antibody
 Organ/Tissue Name  Pubmed Publications
 Intestine Antibodies  >387 publications with FAP and Intestine
 Liver Antibodies  >386 publications with FAP and Liver
 Vascular Antibodies  >159 publications with FAP and Vascular
 Muscle Antibodies  >143 publications with FAP and Muscle
 Stomach Antibodies  >134 publications with FAP and Stomach
 Eye Antibodies  >127 publications with FAP and Eye
 Brain Antibodies  >107 publications with FAP and Brain
 Thyroid Antibodies  >103 publications with FAP and Thyroid
 Skin Antibodies  >90 publications with FAP and Skin
 Lung Antibodies  >80 publications with FAP and Lung
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