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anti-SHMT2 antibody :: Rabbit anti-Human Serine Hydroxymethyltransferase 2 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS2027992 (SPECIAL PROMOTION: Get FREE $5 Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment)
Unit / Price
0.01 mg  /  $110 +1 FREE 8GB USB
0.02 mg  /  $130 +1 FREE 8GB USB
0.05 mg  /  $175 +1 FREE 8GB USB
0.1 mg  /  $225 +1 FREE 8GB USB
0.2 mg  /  $340 +1 FREE 8GB USB
1 mg  /  $800 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Serine Hydroxymethyltransferase 2 (SHMT2), Polyclonal Antibody

★Popular Item★
 Also Known As   

Polyclonal Antibody to Serine Hydroxymethyltransferase 2, Mitochondrial (SHMT2)

 Product Gene Name   

anti-SHMT2 antibody

[Similar Products]
 Matching Pairs    Antibody: Serine Hydroxymethyltransferase 2 (MBS2027992)
Antigen: Serine Hydroxymethyltransferase 2 (MBS2029345)
 Matching Pairs    Unconjugated Antibody: Serine Hydroxymethyltransferase 2 (MBS2027992)
APC-CY7 Conjugated Antibody: Serine Hydroxymethyltransferase 2 (SHMT2) (MBS2074177)
 Matching Pairs    Unconjugated Antibody: Serine Hydroxymethyltransferase 2 (MBS2027992)
PE Conjugated Antibody: Serine Hydroxymethyltransferase 2 (SHMT2) (MBS2074178)
 Matching Pairs    Unconjugated Antibody: Serine Hydroxymethyltransferase 2 (MBS2027992)
APC-CY7 Conjugated Antibody: Serine Hydroxymethyltransferase 2 (SHMT2) (MBS2074179)
 Matching Pairs    Unconjugated Antibody: Serine Hydroxymethyltransferase 2 (MBS2027992)
Cy3 Conjugated Antibody: Serine Hydroxymethyltransferase 2 (SHMT2) (MBS2074180)
 Matching Pairs    Unconjugated Antibody: Serine Hydroxymethyltransferase 2 (MBS2027992)
FITC Conjugated Antibody: Serine Hydroxymethyltransferase 2 (SHMT2) (MBS2074181)
 Matching Pairs    Unconjugated Antibody: Serine Hydroxymethyltransferase 2 (MBS2027992)
HRP Conjugated Antibody: Serine Hydroxymethyltransferase 2 (SHMT2) (MBS2074182)
 Matching Pairs    Unconjugated Antibody: Serine Hydroxymethyltransferase 2 (MBS2027992)
APC-CY7 Conjugated Secondary Antibody: Immunoglobulin G (MBS2090675)
 Matching Pairs    Unconjugated Antibody: Serine Hydroxymethyltransferase 2 (MBS2027992)
Unconjugated Secondary Antibody: Immunoglobulin G (MBS2090678)
 Matching Pairs    Unconjugated Antibody: Serine Hydroxymethyltransferase 2 (MBS2027992)
Biotin Conjugated Antibody: Serine Hydroxymethyltransferase 2, Mitochondrial (SHMT2) (MBS2095680)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    AK315916 mRNA
 3D Structure    ModBase 3D Structure for P34897
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Specificity    The antibody is a rabbit polyclonal antibody raised against SHMT2. It has beenselected for its ability to recognize SHMT2 in immunohistochemical staining andwestern blotting.
 Purity/Purification    Affinity Chromatography
 Form/Format    Liquid
 Concentration    200ug/ml (lot specific)
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 Fragment    SHMT2 (Asn30~His504)
 Organism Species    Homo sapiens (Human)
 Conjugate    No Conjugate
 Immunogen    Recombinant SHMT2 (Asn30~His504) expressed in E Coli.
 Conjugated Antibody    The APC conjugated antibody version of this item is also available as catalog #MBS2074179
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 Preparation and Storage    Store at 4 degree C for frequent use. Stored at -20 degree C to -80 degree C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.
 ISO Certification    Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.
 Supply Chain Verification    Manufactured in a lab with traceable raw materials manufactured on site. Coordinated product portfolio of antibodies, pairs, conjugates, recombinant proteins, and immunoassay materials available. Please inquire.
 Other Notes    Small volumes of anti-SHMT2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-SHMT2 antibody    Knock-Out Validation Antibody
 Applications Tested/Suitable for anti-SHMT2 antibody   

Western Blot (WB), Immunocytochemistry (ICC), Immunohistochemistry (IHC) Formalin/Paraffin, ELISA (EIA)

 Application Notes for anti-SHMT2 antibody    Western blotting: 0.5-2ug/ml
Immunocytochemistry in formalin fixed cells: 5-20ug/ml
Immunohistochemistry in formalin fixed frozen section: 5-20ug/ml
Immunohistochemistry in paraffin section: 5-20ug/ml
Enzyme-linked Immunosorbent Assay: 0.05-2ug/ml
Optimal working dilutions must be determined by end user.
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 Western Blot (WB) Knockout Verification of anti-SHMT2 antibody    Knockout Verification: Lane 1: Wild-type 293T cell lysate; Lane 2: SHMT2 knockout 293T cell lysate; Predicted MW: 54kd Observed MW: 55kd Primary Ab: 1ug/ml Rabbit Anti-Human SHMT2 Antibody Second Ab: 0.2ug/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody
anti-SHMT2 antibody Western Blot (WB) Knockout Verification (WB) image
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 Western Blot (WB) of anti-SHMT2 antibody    Western Blot; Sample: Lane1: Human Lung Tissue; Lane2: Human 293T Cells; Lane3: Human Hela Cells; Lane4: Porcine Pancreas Tissue.
anti-SHMT2 antibody Western Blot (WB) (WB) image
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 Western Blot (WB) of anti-SHMT2 antibody    Western Blot; Sample: Recombinant SHMT2, Human.
anti-SHMT2 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-SHMT2 antibody    DAB staining on IHC-P; Samples: Human Stomach Cancer Tissue.
anti-SHMT2 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-SHMT2 antibody    DAB staining on IHC-P; Samples: Human Rectum Cancer Tissue
anti-SHMT2 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-SHMT2 antibody    DAB staining on IHC-P; Samples: Human Breast Cancer Tissue
anti-SHMT2 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-SHMT2 antibody    FITC staining on IHC-P Simple: Hela cells)
anti-SHMT2 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-SHMT2 antibody    DAB staining on IHC-P; Samples: Human Stomach Tissue
anti-SHMT2 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for SHMT2. It may not necessarily be applicable to this product.
 NCBI GI #    261862346
 NCBI GeneID    6472
 NCBI Accession #    NP_001159828.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001166356.1 [Other Products]
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 UniProt Primary Accession #    P34897 [Other Products]
 UniProt Secondary Accession #    O00740; Q8N1A5; B7Z9F1; E7EQ19; E7EU43 [Other Products]
 UniProt Related Accession #    P34897 [Other Products]
 Molecular Weight    53,455 Da
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 NCBI Official Full Name    serine hydroxymethyltransferase, mitochondrial isoform 2
 NCBI Official Synonym Full Names    serine hydroxymethyltransferase 2
 NCBI Official Symbol    SHMT2 [Similar Products]
 NCBI Official Synonym Symbols   
GLYA; SHMT; HEL-S-51e
[Similar Products]
 NCBI Protein Information    serine hydroxymethyltransferase, mitochondrial
 UniProt Protein Name    Serine hydroxymethyltransferase, mitochondrial
 UniProt Synonym Protein Names   
Glycine hydroxymethyltransferase; Serine methylase
 Protein Family    Serine hydroxymethyltransferase
 UniProt Gene Name    SHMT2 [Similar Products]
 UniProt Synonym Gene Names    SHMT [Similar Products]
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 NCBI Summary for SHMT2    This gene encodes the mitochondrial form of a pyridoxal phosphate-dependent enzyme that catalyzes the reversible reaction of serine and tetrahydrofolate to glycine and 5,10-methylene tetrahydrofolate. The encoded product is primarily responsible for glycine synthesis. The activity of the encoded protein has been suggested to be the primary source of intracellular glycine. The gene which encodes the cytosolic form of this enzyme is located on chromosome 17. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]
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 UniProt Comments for SHMT2    SHMT2: Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Required to prevent uracil accumulation in mtDNA. Interconversion of serine and glycine. Associates with mitochondrial DNA. Belongs to the SHMT family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Amino Acid Metabolism - glycine, serine and threonine; Cofactor and Vitamin Metabolism - one carbon pool by folate; EC 2.1.2.1; Energy Metabolism - methane; Methyltransferase; Mitochondrial; Other Amino Acids Metabolism - cyanoamino acid

Chromosomal Location of Human Ortholog: 12q13.3

Cellular Component: cytoplasm; extracellular exosome; microtubule cytoskeleton; mitochondrial inner membrane; mitochondrial intermembrane space; mitochondrial matrix; mitochondrion; nucleus

Molecular Function: amino acid binding; chromatin binding; glycine hydroxymethyltransferase activity; identical protein binding; L-allo-threonine aldolase activity; protein binding; pyridoxal phosphate binding

Biological Process: folic acid metabolic process; glycine biosynthetic process from serine; glycine metabolic process; L-serine biosynthetic process; L-serine metabolic process; one-carbon metabolic process; positive regulation of cell proliferation; protein homotetramerization; protein tetramerization; tetrahydrofolate metabolic process
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 Research Articles on SHMT2    1. High SHMT2 expression is associated with idiopathic pulmonary fibrosis.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-SHMT2 antibodyPathways associated with anti-SHMT2 antibody
 Reference Product  PubMed Publications
 TYMS antibody  >2 publications with SHMT2 and TYMS
 MTHFR antibody  >1 publications with SHMT2 and MTHFR
 ATIC antibody  >1 publications with SHMT2 and ATIC
 Products by Pathway  Pathway Diagram
 Biosynthesis Of Amino Acids Pathway antibodies  Biosynthesis Of Amino Acids Pathway Diagram
 Biosynthesis Of Amino Acids Pathway antibodies  Biosynthesis Of Amino Acids Pathway Diagram
 C1-unit Interconversion, Eukaryotes Pathway antibodies  C1-unit Interconversion, Eukaryotes Pathway Diagram
 C1-unit Interconversion, Eukaryotes Pathway antibodies  C1-unit Interconversion, Eukaryotes Pathway Diagram
 Carbon Metabolism Pathway antibodies  Carbon Metabolism Pathway Diagram
 Carbon Metabolism Pathway antibodies  Carbon Metabolism Pathway Diagram
 Cyanoamino Acid Metabolism Pathway antibodies  Cyanoamino Acid Metabolism Pathway Diagram
 Cyanoamino Acid Metabolism Pathway antibodies  Cyanoamino Acid Metabolism Pathway Diagram
 Glycine Metabolism Pathway antibodies  Glycine Metabolism Pathway Diagram
 Glycine, Serine And Threonine Metabolism Pathway antibodies  Glycine, Serine And Threonine Metabolism Pathway Diagram
Diseases associated with anti-SHMT2 antibodyOrgans/Tissues associated with anti-SHMT2 antibody
 Disease Name  Pubmed Publications
 Brain Diseases Antibodies  >1 publications with SHMT2 and Brain Diseases
 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >3 publications with SHMT2 and Lung
 Blood Antibodies  >2 publications with SHMT2 and Blood
 Liver Antibodies  >2 publications with SHMT2 and Liver
 Brain Antibodies  >2 publications with SHMT2 and Brain
 Adipose Tissue Antibodies  >1 publications with SHMT2 and Adipose Tissue
 Vascular Antibodies  >1 publications with SHMT2 and Vascular
 Ovary Antibodies  >1 publications with SHMT2 and Ovary
 Connective Tissue Antibodies  >1 publications with SHMT2 and Connective Tissue
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