Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
1.855.MyBioSource
Fax 1.858.633.0166    Email sales@mybiosource.com 
tel/fax
menu1 Home Products Ordering Company Help menu7
bottom
   MyBioSource rightarrow Antibody rightarrow TBK1 rightarrow Polyclonal TBK1  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Menu separator
separator
ELISA Kit ELISA Kit
CLIA Kit CLIA Kit
PCR Kit PCR Kit
Monoclonal Antibody Monoclonal Antibody
Polyclonal Antibody Polyclonal Antibody
Secondary Antibody Secondary Antibody
Antigen Antigen
Biochemical Biochemical
cDNA Clone cDNA Clone
siRNA siRNA
Peptide Peptide
Recombinant/Purified Protein Rec./Purified Protein

Custom ELISA Kit Custom ELISA Kit
Custom Protein Custom Protein
Custom Antibody Custom Antibody
Antibody Matched Pairs Antibody Matched Pairs
Antibody & Corresponding Blocking Peptide Pairs Antibody Peptide Pairs
Phospho-Specific Antibodies Phospho Antibodies
Products by Disease Products by Disease
Products by Pathway Products by Pathway
Products by Tissue Products by Tissue

arrow Advanced Search
arrow Submit Technical Q&A
arrow International Distributors
arrow Contact Us
separator
Our Best Sellers moreseparator
separator
 • EDG2 Antibody
 • IkappaB-alpha (IKBA) Antibody
 • PLAC1 Antibody
 • Parathyroid Hormone Related Protein (PTHrP) ELISA Kit
 • Caveolin-1 (Cav-1) ELISA Kit
 • NogoA (RTN4) Blocking Peptide
 • Met (Phospho-Tyr1356) Antibody
 • prostate transmembrane protein, androgen induced 1 (PMEPA1) ELISA Kit
 • A1BG - GAB Antibody
 • Anti-Biotin, HRP Antibody
 • Osteocalcin [40-49] IgG fraction (BGLAP) Antibody
 • inhibitor of DNA binding 1, dominant negative helix-loop-hel... Antibody
 • tumor necrosis factor receptor superfamily, member 9 (TNFRSF... ELISA Kit
 • CYTOMEGALOVIRUS Antigen
 downarrow more ...
separator
separator
DatasheetFull DatasheetPrinter Friendly DatasheetPrint This DatasheetAdd to Compare ListHave Questions? Ask UsRequest for a Quotation today

anti-TBK1 antibody :: Rabbit anti-Human Serine/threonine-protein kinase TBK1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS7004345
Unit / Price
0.05 mg  /  $160 +1 FREE 8GB USB
0.1 mg  /  $235 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Serine/threonine-protein kinase TBK1, Polyclonal Antibody

★Popular Item★
 Also Known As   

Rabbit anti-human Serine/threonine-protein kinase TBK1 polyclonal Antibody

 Product Synonym Names    NF-kappa-B-activating kinase T2K TANK-binding kinase 1 TBK1 NAK
 Product Gene Name   

anti-TBK1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
Table BarTOPTable Bar
 OMIM    177700
 3D Structure    ModBase 3D Structure for Q9UHD2
Section Bar
 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
Section Bar
 Purity/Purification    Caprylic Acid Ammonium Sulfate Precipitation purified
 Form/Format    Liquid
Section Bar
 Immunogen    Recombinant human Serine/threonine-protein kinase TBK1 protein
 Conjugation    Non-conjugated
 Storage Buffer    Preservative: 0.03% Proclin 300; Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-33895 / sc-33896 / sc-33897 / sc-7221
Section Bar
 Preparation and Storage    Shipped at 4 degree C. Upon delivery, aliquot and store at -20 degree C or -80 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-TBK1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Table BarTOPTable Bar
 

Related Product Information for anti-TBK1 antibody

   Serine/threonine kinase that plays an essential role in regulating inflammatory responses to foreign agents. Following activation of toll-like receptors by viral or bacterial components, associates with TRAF3 and TANK and phosphorylates interferon regulatory factors (IRFs) IRF3 and IRF7 as well as DDX3X. This activity allows subsequent homodimerization and nuclear translocation of the IRFs leading to transcriptional activation of pro-inflammatory and antiviral genes including IFNA and IFNB. In order to establish such an antiviral state, TBK1 form several different complexes whose composition depends on the type of cell and cellular stimuli. Thus, several scaffolding molecules including FADD, TRADD, MAVS, AZI2, TANK or TBKBP1/SINTBAD can be recruited to the TBK1-containing-complexes. Under particular conditions, functions as a NF-kappa-B effector by phosphorylating NF-kappa-B inhibitor alpha/NFKBIA, IKBKB or RELA to translocate NF-Kappa-B to the nucleus. Restricts bacterial proliferation by phosphorylating the autophagy receptor OPTN/Optineurin on 'Ser-177', thus enhancing LC3 binding affinity and antibacterial autophagy. Phosphorylates and activates AKT1. Seems to play a role in energy balance regulation by sustaining a state of chronic, low-grade inflammation in obesity, wich leads to a negative impact on insulin sensitivity. Attenuates retroviral budding by phosphorylating the endosomal sorting complex required for transport-I (ESCRT-I) subunit VPS37C. Phosphorylates Borna disease virus (BDV) P protein.
 Applications Tested/Suitable for anti-TBK1 antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-TBK1 antibody    Recommended dilution: WB:1:500-2000, IHC:1:20-1:200
Section Bar
 Immunohistochemistry (IHC) of anti-TBK1 antibody    Immunohistochemistry of paraffin-embedded human liver tissue using MBS7004345 at dilution 1:100
anti-TBK1 antibody Immunohistochemistry (IHC) (IHC) image
Section Bar
 Immunohistochemistry (IHC) of anti-TBK1 antibody    Immunohistochemistry of paraffin-embedded human adrenal gland tissue using MBS7004345 at dilution 1:100
anti-TBK1 antibody Immunohistochemistry (IHC) (IHC) image
Section Bar
 Immunohistochemistry (IHC) of anti-TBK1 antibody    Immunofluorescence staining of Hela cells cells with MBS7004345 at 1:333,counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4 degree C.The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG (H+L).
anti-TBK1 antibody Immunohistochemistry (IHC) (IHC) image
Table BarTOPTable Bar
NCBI/Uniprot data below describe general gene information for TBK1. It may not necessarily be applicable to this product.
 NCBI GI #    7019547
 NCBI GeneID    29110
 NCBI Accession #    NP_037386.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_013254.3 [Other Products]
Section Bar
 UniProt Primary Accession #    Q9UHD2 [Other Products]
 UniProt Secondary Accession #    Q8IYV3; Q9NUJ5; A8K4S4 [Other Products]
 UniProt Related Accession #    Q9UHD2 [Other Products]
 Molecular Weight    83,642 Da [Similar Products]
Table BarTOPTable Bar
 NCBI Official Full Name    serine/threonine-protein kinase TBK1
 NCBI Official Synonym Full Names    TANK-binding kinase 1
 NCBI Official Symbol    TBK1 [Similar Products]
 NCBI Official Synonym Symbols   
NAK; T2K; FTDALS4
[Similar Products]
 NCBI Protein Information    serine/threonine-protein kinase TBK1
 UniProt Protein Name    Serine/threonine-protein kinase TBK1
 UniProt Synonym Protein Names   
NF-kappa-B-activating kinase; T2K; TANK-binding kinase 1
 Protein Family    Serine/threonine-protein kinase
 UniProt Gene Name    TBK1 [Similar Products]
 UniProt Synonym Gene Names    NAK [Similar Products]
 UniProt Entry Name    TBK1_HUMAN
Section Bar
 NCBI Summary for TBK1    The NF-kappa-B (NFKB) complex of proteins is inhibited by I-kappa-B (IKB) proteins, which inactivate NFKB by trapping it in the cytoplasm. Phosphorylation of serine residues on the IKB proteins by IKB kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation and nuclear translocation of the NFKB complex. The protein encoded by this gene is similar to IKB kinases and can mediate NFKB activation in response to certain growth factors. [provided by RefSeq, Oct 2010]
Section Bar
 UniProt Comments for TBK1    TBK1: a protein kinase of the IKK family. Can mediate NFkB activation in response to certain growth factors. Forms a complex with the IKB protein TANK and TRAF2 and release the NFKB inhibition caused by TANK.

Protein type: Kinase, protein; EC 2.7.11.1; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Other group; IKK family

Chromosomal Location of Human Ortholog: 12q14.1

Cellular Component: cytoplasm; cytosol; endosome membrane

Molecular Function: ATP binding; nucleic acid binding; phosphoprotein binding; protein binding; protein kinase activity; protein serine/threonine kinase activity

Biological Process: defense response to Gram-positive bacterium; defense response to virus; I-kappaB kinase/NF-kappaB cascade; inflammatory response; innate immune response; interferon type I production; MyD88-independent toll-like receptor signaling pathway; negative regulation of interferon type I production; peptidyl-serine phosphorylation; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of interferon type I production; positive regulation of interferon-alpha production; positive regulation of interferon-beta biosynthetic process; positive regulation of interferon-beta production; positive regulation of peptidyl-serine phosphorylation; positive regulation of transcription from RNA polymerase II promoter; response to virus; toll-like receptor 3 signaling pathway; toll-like receptor 4 signaling pathway; toll-like receptor signaling pathway; viral reproduction

Disease: Frontotemporal Dementia And/or Amyotrophic Lateral Sclerosis 4
Table BarTOPTable Bar
 Research Articles on TBK1    1. findings demonstrate a novel regulatory circuit in which STING and TBK1 reciprocally regulate each other to enable efficient antiviral signaling activation, and PPM1A dephosphorylates STING and TBK1
Table BarTOPTable Bar
 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Table BarTOPTable Bar
Products associated with anti-TBK1 antibodyPathways associated with anti-TBK1 antibody
 Reference Product  PubMed Publications
 IRF3 antibody  >279 publications with TBK1 and IRF3
 TANK antibody  >263 publications with TBK1 and TANK
 MAVS antibody  >57 publications with TBK1 and MAVS
 TRAF3 antibody  >40 publications with TBK1 and TRAF3
 TICAM1 antibody  >22 publications with TBK1 and TICAM1
 TRAF2 antibody  >9 publications with TBK1 and TRAF2
 TMEM173 antibody  >5 publications with TBK1 and TMEM173
 TBKBP1 antibody  >3 publications with TBK1 and TBKBP1
 AZI2 antibody  >3 publications with TBK1 and AZI2
 Products by Pathway  Pathway Diagram
 Activated TLR4 Signalling Pathway antibodies  Activated TLR4 Signalling Pathway Diagram
 Activation Of IRF3/IRF7 Mediated By TBK1/IKK Epsilon Pathway antibodies  Activation Of IRF3/IRF7 Mediated By TBK1/IKK Epsilon Pathway Diagram
 Cytosolic DNA-sensing Pathway antibodies  Cytosolic DNA-sensing Pathway Diagram
 Cytosolic DNA-sensing Pathway antibodies  Cytosolic DNA-sensing Pathway Diagram
 Cytosolic Sensors Of Pathogen-associated DNA Pathway antibodies  Cytosolic Sensors Of Pathogen-associated DNA Pathway Diagram
 Epstein-Barr Virus Infection Pathway antibodies  Epstein-Barr Virus Infection Pathway Diagram
 Epstein-Barr Virus Infection Pathway antibodies  Epstein-Barr Virus Infection Pathway Diagram
 Hepatitis B Pathway antibodies  Hepatitis B Pathway Diagram
 Hepatitis C Pathway antibodies  Hepatitis C Pathway Diagram
 Hepatitis C Pathway antibodies  Hepatitis C Pathway Diagram
Diseases associated with anti-TBK1 antibodyOrgans/Tissues associated with anti-TBK1 antibody
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >83 publications with TBK1 and Inflammation
 Necrosis Antibodies  >64 publications with TBK1 and Necrosis
 Liver Diseases Antibodies  >21 publications with TBK1 and Liver Diseases
 Lung Neoplasms Antibodies  >15 publications with TBK1 and Lung Neoplasms
 Breast Neoplasms Antibodies  >9 publications with TBK1 and Breast Neoplasms
 Cell Transformation, Neoplastic Antibodies  >9 publications with TBK1 and Cell Transformation, Neoplastic
 Atherosclerosis Antibodies  >8 publications with TBK1 and Atherosclerosis
 Kidney Diseases Antibodies  >7 publications with TBK1 and Kidney Diseases
 Insulin Resistance Antibodies  >7 publications with TBK1 and Insulin Resistance
 Carcinoma, Hepatocellular Antibodies  >5 publications with TBK1 and Carcinoma, Hepatocellular
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >62 publications with TBK1 and Blood
 Bone Antibodies  >30 publications with TBK1 and Bone
 Bone Marrow Antibodies  >28 publications with TBK1 and Bone Marrow
 Lung Antibodies  >26 publications with TBK1 and Lung
 Liver Antibodies  >23 publications with TBK1 and Liver
 Brain Antibodies  >21 publications with TBK1 and Brain
 Kidney Antibodies  >19 publications with TBK1 and Kidney
 Eye Antibodies  >13 publications with TBK1 and Eye
 Skin Antibodies  >10 publications with TBK1 and Skin
 Spleen Antibodies  >9 publications with TBK1 and Spleen
Table BarTOPTable Bar
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions