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anti-HTR2C antibody :: Goat Serotonin receptor 2C/HTR2C Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS420937
Western Blot (WB)
Unit / Price
0.1 mg  /  $300 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Serotonin receptor 2C/HTR2C, Polyclonal Antibody

 Also Known As   

Goat anti-Serotonin receptor 2C/HTR2C Antibody

 Product Synonym Names    HTR2C; 5-hydroxytryptamine (serotonin) receptor 2C; HGNC: 5295; 5-HT2C; HTR1C; RP11-810O3.1; 5-HTR2C; OTTHUMP00000023868; serotonin 5-HT-2C receptor; serotonin receptor 2C; HTR2C antibody; 5-hydroxytryptamine (serotonin) receptor 2C antibody; HGNC: 5295 antibody; 5-HT2C antibody; HTR1C antibody; RP11-810O3.1 antibody; 5-HTR2C antibody; OTTHUMP00000023868 antibody; serotonin 5-HT-2C receptor antibody; serotonin receptor 2C antibody; Serotonin receptor 2C; Serotonin receptor 2C / HTR2C
 Product Gene Name   

anti-HTR2C antibody

[Similar Products]
 Antibody/Peptide Pairs    Serotonin receptor 2C / HTR2C peptide (MBS425363) is used for blocking the activity of Serotonin receptor 2C/HTR2C antibody (MBS420937)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    QVENLELPVN
 OMIM    312861
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 Clonality    Polyclonal
 Host    Goat
 Species Reactivity    Tested: Human; Expected from sequence similarity: Human, Mouse, Rat, Dog, Cow
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 Purity/Purification    Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
 Form/Format    Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
 Concentration    100ug specific antibody in 200ul (lot specific)
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 Immunogen    Peptide with sequence C-QVENLELPVN, from the internal region of the protein sequence according to NP_000859.1.
 Epitope    Internal region
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 Preparation and Storage    Aliquot and store at -20 degree C. Minimize freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of anti-HTR2C antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-HTR2C antibody   

Peptide ELISA (EIA), Western Blot (WB)

 Application Notes for anti-HTR2C antibody    Peptide ELISA: Antibody detection limit dilution 1: 64000.
Western Blot: Approx 50kDa band observed in lysates of Human immortalised Lymphoblastoids, T cell MOLT4 and monocytic cell line U937 (calculated MW of 51.8kDa according to NP_000859.1). Recommended concentration: 1-3ug/ml.
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 Western Blot (WB) of anti-HTR2C antibody    (1ug/ml) staining of EBV immortalised Lymphoblastoid lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
anti-HTR2C antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for HTR2C. It may not necessarily be applicable to this product.
 NCBI GI #    4504541
 NCBI GeneID    3358
 NCBI Accession #    NP_000859.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000868.3 [Other Products]
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 UniProt Secondary Accession #    Q5VUF8; Q9NP28; B1AMW4 [Other Products]
 UniProt Related Accession #    P28335 [Other Products]
 Molecular Weight    28,055 Da
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 NCBI Official Full Name    5-hydroxytryptamine receptor 2C isoform a
 NCBI Official Synonym Full Names    5-hydroxytryptamine receptor 2C
 NCBI Official Symbol    HTR2C [Similar Products]
 NCBI Official Synonym Symbols   
HTR1C; 5-HT1C; 5-HT2C; 5HTR2C; 5-HTR2C
[Similar Products]
 NCBI Protein Information    5-hydroxytryptamine receptor 2C
 UniProt Protein Name    5-hydroxytryptamine receptor 2C
 UniProt Synonym Protein Names   
5-hydroxytryptamine receptor 1C; 5-HT-1C; 5-HT1C; Serotonin receptor 2C
 Protein Family    5-hydroxytryptamine receptor
 UniProt Gene Name    HTR2C [Similar Products]
 UniProt Synonym Gene Names    HTR1C; 5-HT-2C; 5-HT2C; 5-HTR2C; 5-HT-1C; 5-HT1C [Similar Products]
 UniProt Entry Name    5HT2C_HUMAN
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 NCBI Summary for HTR2C    This gene encodes a seven-transmembrane G-protein-coupled receptor. The encoded protein responds to signaling through the neurotransmitter serotonin. The mRNA of this gene is subject to multiple RNA editing events, where adenosine residues encoded by the genome are converted to inosines. RNA editing is predicted to alter the structure of the second intracellular loop, thereby generating alternate protein forms with decreased ability to interact with G proteins. Abnormalities in RNA editing of this gene have been detected in victims of suicide that suffer from depression. In addition, naturally-occuring variation in the promoter and 5' non-coding and coding regions of this gene may show statistically-significant association with mental illness and behavioral disorders. Alternative splicing results in multiple different transcript variants. [provided by RefSeq, Jan 2015]
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 UniProt Comments for HTR2C    5-HT(2C): a G-protein coupled receptor. One of several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. Mediates its action by activating a phosphatidylinositol-calcium second messenger system.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR; GPCR, family 1

Chromosomal Location of Human Ortholog: Xq24

Cellular Component: cytosol; integral to plasma membrane; plasma membrane

Molecular Function: 5-HT2 receptor activity; drug binding; serotonin binding; serotonin receptor activity

Biological Process: behavioral fear response; cellular calcium ion homeostasis; cGMP biosynthetic process; elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); feeding behavior; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); locomotory behavior; positive regulation of fat cell differentiation; positive regulation of phosphatidylinositol biosynthetic process; regulation of appetite; regulation of corticotropin-releasing hormone secretion; regulation of neurological process; release of sequestered calcium ion into cytosol; response to drug; serotonin receptor signaling pathway; serotonin receptor, phospholipase C activating pathway; synaptic transmission
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 Research Articles on HTR2C    1. No significant differences were found between the genotype distribution and allele frequencies of the OSAHS group and the control group regarding the T102C polymorphisms of the 5-HTR 2A gene and the G796C polymorphisms of the 5-HTR 2C gene.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-HTR2C antibodyDiseases associated with anti-HTR2C antibody
 Products by Pathway  Pathway Diagram
 Amine Ligand-binding Receptors Pathway antibodies  Amine Ligand-binding Receptors Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 G Alpha (q) Signalling Events Pathway antibodies  G Alpha (q) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 GPCRs, Class A Rhodopsin-like Pathway antibodies  GPCRs, Class A Rhodopsin-like Pathway Diagram
 Gap Junction Pathway antibodies  Gap Junction Pathway Diagram
 Gap Junction Pathway antibodies  Gap Junction Pathway Diagram
 Disease Name  Pubmed Publications
 Mental Disorders Antibodies  >98 publications with HTR2C and Mental Disorders
 Schizophrenia Antibodies  >53 publications with HTR2C and Schizophrenia
 Weight Gain Antibodies  >41 publications with HTR2C and Weight Gain
 Nervous System Diseases Antibodies  >32 publications with HTR2C and Nervous System Diseases
 Obesity Antibodies  >27 publications with HTR2C and Obesity
 Mood Disorders Antibodies  >20 publications with HTR2C and Mood Disorders
 Depressive Disorder Antibodies  >17 publications with HTR2C and Depressive Disorder
 Bipolar Disorder Antibodies  >17 publications with HTR2C and Bipolar Disorder
 Movement Disorders Antibodies  >14 publications with HTR2C and Movement Disorders
 Depressive Disorder, Major Antibodies  >11 publications with HTR2C and Depressive Disorder, Major
Organs/Tissues associated with anti-HTR2C antibody
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >66 publications with HTR2C and Brain
 Muscle Antibodies  >3 publications with HTR2C and Muscle
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