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anti-PON1 antibody :: Rabbit anti-Human Serum paraoxonase/arylesterase 1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS7004898
Unit / Price
0.05 mg  /  $160 +1 FREE 8GB USB
0.1 mg  /  $235 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Serum paraoxonase/arylesterase 1 (PON1), Polyclonal Antibody

★Popular Item★
 Also Known As   

Rabbit anti-Human Serum paraoxonase/arylesterase 1 polyclonal Antibody

 Product Synonym Names    Aromatic esterase 1; K-45; Serum aryldialkylphosphatase 1; PON1; PON
 Product Gene Name   

anti-PON1 antibody

[Similar Products]
 Product Synonym Gene Name    PON1 [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    168820
 3D Structure    ModBase 3D Structure for P27169
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Purity/Purification    Caprylic Acid Ammonium Sulfate Precipitation purified
 Form/Format    Liquid
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 Immunogen    Recombinant human Serum paraoxonase/arylesterase 1 protein
 Conjugation    Non-conjugated
 Storage Buffer    Preservative: 0.03% Proclin 300; Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-21146 / sc-21147 / sc-133919 / sc-25791
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery, aliquot and store at -20 degree C or -80 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-PON1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-PON1 antibody

   Hydrolyzes the toxic metabolites of a variety of organophosphorus insecticides. Capable of hydrolyzing a broad spectrum of organophosphate substrates and lactones, and a number of aromatic carboxylic acid esters. Mediates an enzymatic protection of low density lipoproteins against oxidative modification and the consequent series of events leading to atheroma formation.

The enzyme encoded by this gene is an arylesterase that mainly hydrolyzes paroxon to produce p-nitrophenol. Paroxon is an organophosphorus anticholinesterase compound that is produced in vivo by oxidation of the insecticide parathion. Polymorphisms in this gene are a risk factor in coronary artery disease. The gene is found in a cluster of three related paraoxonase genes at 7q21.3.
 Product Categories/Family for anti-PON1 antibody    Cardiovascular
 Applications Tested/Suitable for anti-PON1 antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-PON1 antibody    Recommended dilution: WB:1:500-2000, IHC:1:20-1:200
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 Western Blot (WB) of anti-PON1 antibody    All lanes: Serum paraoxonase/arylesterase 1 antibody at 2ug/ml+mouse liver tissue
Secondary
Goat polyclonal to Rabbit IgG at 1/10000 dilution
Predicted band size: 40kDa
Observed band size: 40 kDa

anti-PON1 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-PON1 antibody    Immunohistochemistry of paraffin-embeded mouse liver using MBS7004898 at dilution of 1:100
anti-PON1 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-PON1 antibody    Immunohistochemistry of paraffin-embeded human prostate using MBS7004898 at dilution of 1:100
anti-PON1 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for PON1. It may not necessarily be applicable to this product.
 NCBI GI #    19923106
 NCBI GeneID    5444
 NCBI Accession #    NP_000437.3 [Other Products]
 NCBI GenBank Nucleotide #    NM_000446.5 [Other Products]
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 UniProt Primary Accession #    P27169 [Other Products]
 UniProt Secondary Accession #    Q16052; Q6B0J6; Q9UCB1; B2RA40 [Other Products]
 UniProt Related Accession #    P27169 [Other Products]
 Molecular Weight    39,731 Da [Similar Products]
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 NCBI Official Full Name    serum paraoxonase/arylesterase 1
 NCBI Official Synonym Full Names    paraoxonase 1
 NCBI Official Symbol    PON1 [Similar Products]
 NCBI Official Synonym Symbols   
ESA; PON; MVCD5
[Similar Products]
 NCBI Protein Information    serum paraoxonase/arylesterase 1
 UniProt Protein Name    Serum paraoxonase/arylesterase 1
 UniProt Synonym Protein Names   
Aromatic esterase 1; A-esterase 1; K-45; Serum aryldialkylphosphatase 1
 Protein Family    Serum paraoxonase/arylesterase
 UniProt Gene Name    PON1 [Similar Products]
 UniProt Synonym Gene Names    PON; A-esterase 1 [Similar Products]
 UniProt Entry Name    PON1_HUMAN
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 NCBI Summary for PON1    The enzyme encoded by this gene is an arylesterase that mainly hydrolyzes paroxon to produce p-nitrophenol. Paroxon is an organophosphorus anticholinesterase compound that is produced in vivo by oxidation of the insecticide parathion. Polymorphisms in this gene are a risk factor in coronary artery disease. The gene is found in a cluster of three related paraoxonase genes at 7q21.3. [provided by RefSeq, Oct 2008]
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 UniProt Comments for PON1    PON1: Hydrolyzes the toxic metabolites of a variety of organophosphorus insecticides. Capable of hydrolyzing a broad spectrum of organophosphate substrates and lactones, and a number of aromatic carboxylic acid esters. Mediates an enzymatic protection of low density lipoproteins against oxidative modification and the consequent series of events leading to atheroma formation. Genetic variation in PON1 is associated with susceptibility to microvascular complications of diabetes type 5 (MVCD5). These are pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new- onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis. Homozygosity for the Leu-54 allele is strongly associated with the development of retinal disease in diabetic patients. Belongs to the paraoxonase family.

Protein type: EC 3.1.1.81; Secreted; Motility/polarity/chemotaxis; EC 3.1.1.2; Secreted, signal peptide; EC 3.1.8.1; Phosphatase (non-protein); Hydrolase; Lipid-binding

Chromosomal Location of Human Ortholog: 7q21.3

Cellular Component: extracellular region; extracellular space; intracellular membrane-bound organelle

Molecular Function: aryldialkylphosphatase activity; arylesterase activity; calcium ion binding; phospholipid binding; protein homodimerization activity

Biological Process: aromatic compound catabolic process; carboxylic acid catabolic process; dephosphorylation; organophosphate catabolic process; phosphatidylcholine metabolic process; positive regulation of binding; positive regulation of transporter activity; response to external stimulus; response to nutrient levels; response to toxin

Disease: Microvascular Complications Of Diabetes, Susceptibility To, 5
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 Research Articles on PON1    1. PON-1 and ferroxidase activities in older patients with mild cognitive impairment, late onset Alzheimer's disease or vascular dementia
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-PON1 antibodyPathways associated with anti-PON1 antibody
 Reference Product  PubMed Publications
 APOE antibody  >86 publications with PON1 and APOE
 APOA1 antibody  >39 publications with PON1 and APOA1
 CLU antibody  >11 publications with PON1 and CLU
 PPARG antibody  >9 publications with PON1 and PPARG
 IL6 antibody  >5 publications with PON1 and IL6
 LPA antibody  >3 publications with PON1 and LPA
 PPARA antibody  >3 publications with PON1 and PPARA
 SREBF2 antibody  >2 publications with PON1 and SREBF2
 APOA2 antibody  >2 publications with PON1 and APOA2
 ALB antibody  >1 publications with PON1 and ALB
 Products by Pathway  Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Phase I, Non P450 Pathway antibodies  Phase I, Non P450 Pathway Diagram
Diseases associated with anti-PON1 antibodyOrgans/Tissues associated with anti-PON1 antibody
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >706 publications with PON1 and Cardiovascular Diseases
 Atherosclerosis Antibodies  >552 publications with PON1 and Atherosclerosis
 Coronary Disease Antibodies  >296 publications with PON1 and Coronary Disease
 Diabetes Mellitus Antibodies  >185 publications with PON1 and Diabetes Mellitus
 Inflammation Antibodies  >176 publications with PON1 and Inflammation
 Coronary Artery Disease Antibodies  >174 publications with PON1 and Coronary Artery Disease
 Kidney Diseases Antibodies  >90 publications with PON1 and Kidney Diseases
 Poisoning Antibodies  >89 publications with PON1 and Poisoning
 Organophosphate Poisoning Antibodies  >49 publications with PON1 and Organophosphate Poisoning
 Hypercholesterolemia Antibodies  >47 publications with PON1 and Hypercholesterolemia
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >206 publications with PON1 and Liver
 Brain Antibodies  >87 publications with PON1 and Brain
 Lung Antibodies  >49 publications with PON1 and Lung
 Bone Antibodies  >14 publications with PON1 and Bone
 Pancreas Antibodies  >8 publications with PON1 and Pancreas
 Testis Antibodies  >3 publications with PON1 and Testis
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