NP_055200.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
16,740 Da
NCBI Official Full Name
sialic acid-binding Ig-like lectin 7 isoform 1
NCBI Official Synonym Full Names
sialic acid binding Ig like lectin 7
NCBI Official Synonym Symbols
p75; QA79; AIRM1; CD328; CDw328; D-siglec; SIGLEC-7; SIGLECP2; SIGLEC19P; p75/AIRM1 [Similar Products]
NCBI Protein Information
sialic acid-binding Ig-like lectin 7
UniProt Protein Name
Sialic acid-binding Ig-like lectin 7
UniProt Synonym Protein Names
Adhesion inhibitory receptor molecule 1; AIRM-1; CDw328; D-siglec; QA79 membrane protein; p75; CD_antigen: CD328
UniProt Synonym Gene Names
UniProt Comments for SIGLEC7
SIGLEC7: Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- and alpha-2,6-linked sialic acid. Also binds disialogangliosides (disialogalactosyl globoside, disialyl lactotetraosylceramide and disialyl GalNAc lactotetraoslylceramide). The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Mediates inhibition of natural killer cells cytotoxicity. May play a role in hemopoiesis. Inhibits differentiation of CD34+ cell precursors towards myelomonocytic cell lineage and proliferation of leukemic myeloid cells (in vitro). Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Cell adhesion; Membrane protein, integral
Chromosomal Location of Human Ortholog: 19q13.41
Cellular Component: integral to plasma membrane; plasma membrane
Molecular Function: receptor activity
Biological Process: regulation of immune response
Research Articles on SIGLEC7
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Products associated with anti-SIGLEC7 antibody
Diseases associated with anti-SIGLEC7 antibody
Organs/Tissues associated with anti-SIGLEC7 antibody
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