NP_001103820.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
paired amphipathic helix protein Sin3a isoform 2
NCBI Official Synonym Full Names
transcriptional regulator, SIN3A (yeast)
NCBI Official Synonym Symbols
Sin3; mSin3A; AW553200; mKIAA4126 [Similar Products]
NCBI Protein Information
paired amphipathic helix protein Sin3a
UniProt Protein Name
Paired amphipathic helix protein Sin3a
UniProt Synonym Protein Names
Histone deacetylase complex subunit Sin3a; Transcriptional corepressor Sin3a
UniProt Synonym Gene Names
UniProt Entry Name
SIN3A_MOUSE
UniProt Comments for Sin3a
SIN3A: Acts as a transcriptional repressor. Corepressor for REST. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Also interacts with MXD1-MAX heterodimers to repress transcription by tethering SIN3A to DNA. Acts cooperatively with OGT to repress transcription in parallel with histone deacetylation. Interacts with BAZ2A, MXD3, MXD4, MBD2, NCOR1, NR4A2, REST, RLIM, SAP30, SETDB1 and SMYD2. Interacts with PHF12 in a complex composed of HDAC1, PHF12 and SAP30. Interacts with ARID4B, BRMS1L, DACH1, HCFC1, HDAC1, HDAC2, MXI1, SAP30L, SAP130, SFPQ, SUDS3 and TOPORS. Interacts with TET1; the interaction recruits SIN3A to gene promoters. Interacts with OGT (via TPRs 1-6); the interaction mediates transcriptional repression in parallel with histone deacetylase.
Protein type: Nucleolus; Nuclear receptor co-regulator; Transcription, coactivator/corepressor
Cellular Component: nucleoplasm; kinetochore; transcription factor complex; intercellular bridge; protein complex; transcriptional repressor complex; Sin3 complex; cytoplasm; chromatin; nucleus
Molecular Function: protein binding; DNA binding; RNA binding; protein deacetylase activity; protein complex binding; chromatin binding; histone deacetylase activity; transcription factor binding; transcription factor activity; transcription corepressor activity
Biological Process: transcription from RNA polymerase II promoter; positive regulation of chromatin silencing; transcription, DNA-dependent; in utero embryonic development; rhythmic process; histone deacetylation; negative regulation of transcription from RNA polymerase II promoter; response to organic nitrogen; protein amino acid deacetylation; regulation of transcription, DNA-dependent; response to methylglyoxal; hemopoietic progenitor cell differentiation; negative regulation of circadian rhythm; positive regulation of transcription from RNA polymerase II promoter; regulation of transcription from RNA polymerase II promoter in response to oxidative stress; negative regulation of transcription, DNA-dependent; DNA replication; positive regulation of defense response to virus by host; activation of innate immune response; aging; negative regulation of apoptosis
Product References and Citations for anti-Sin3a antibody
Baltus, G.A., et al. J. Biol. Chem. 284(11):6998-7006(2009) Anderson, D.M., et al. Dev. Dyn. 238(3):572-580(2009) Chang, S., et al. J. Immunol. 181(12):8372-8381(2008) van Oevelen, C., et al. Mol. Cell 32(3):359-370(2008) Wilkinson, D.S., et al. Mol. Cell. Biol. 28(6):1988-1998(2008)
Research Articles on Sin3a
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Products associated with anti-Sin3a antibody
Pathways associated with anti-Sin3a antibody
Diseases associated with anti-Sin3a antibody
Organs/Tissues associated with anti-Sin3a antibody
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