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anti-SSB antibody :: Human Sjogren Syndrome Antigen B Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS619692 anti-SSB antibody
Unit / Price
2 mL  /  $475 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Sjogren Syndrome Antigen B (SSB), Polyclonal Antibody

 Also Known As   

Sjogren Syndrome Antigen B (SSB, La autoantigen, Lupus La Protein)

 Product Synonym Names    Anti -Sjogren Syndrome Antigen B (SSB, La autoantigen, Lupus La Protein)
 Product Gene Name   

anti-SSB antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 2; NC_000002.11 (170655389..170668575). Location: 2q31.1
 3D Structure    ModBase 3D Structure for Q2F832
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 Clonality    Polyclonal
 Host    Human
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 Specificity    Recognizes human SSB antigen. Does not recognize purified Scl-70, Sm, Sm/RNP, and Jo-1 antigens. Anti-SSA activity is detected in this ELISA system.
 Purity/Purification    Serum
Purified by delipidization and defibrination.
 Form/Format    Supplied as a lyophilized powder from 0.01M phosphate, 0.13M sodium chloride, pH 7.2, 0.02% sodium azide. Reconstitute with 2ml of deionized water.
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 Immunogen    Human SSB antigen from human plasma.
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 Preparation and Storage    Lyophilized powder may be stored at -20 degree C. Reconstitute with sterile ddH2O, sterile 40-50% glycerol, aliquot and store at -20 degree C. Reconstituted product is stable for 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
 Other Notes    Small volumes of anti-SSB antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-SSB antibody

   SSB is involved in diverse aspects of RNA metabolism, including binding and protecting 3-prime UUU(OH) elements of newly RNA polymerase III-transcribed RNA, processing 5-prime and 3-prime ends of pre-tRNA precursors, acting as an RNA chaperone, and binding viral RNAs associated with hepatitis C virus. SSB protein was originally defined by its reactivity with autoantibodies from patients with Sjogren syndrome and systemic lupus erythematosus.La is involved in diverse aspects of RNA metabolism, including binding and protecting 3-prime UUU(OH) elements of newly RNA polymerase III (see MIM 606007)-transcribed RNA, processing 5-prime and 3-prime ends of pre-tRNA precursors, acting as an RNA chaperone, and binding viral RNAs associated with hepatitis C virus. La protein was originally defined by its reactivity with autoantibodies from patients with Sjogren syndrome (MIM 270150) and systemic lupus erythematosus (SLE; MIM 152700) (Teplova et al., 2006).
 Product Categories/Family for anti-SSB antibody    Antibodies; Abs to Disease Markers
 Applications Tested/Suitable for anti-SSB antibody   

ELISA (EL/EIA)

 Application Notes for anti-SSB antibody    Suitable for use in ELISA and Immunodiffusion.
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NCBI/Uniprot data below describe general gene information for SSB. It may not necessarily be applicable to this product.
 NCBI GI #    86651712
 NCBI GeneID    6741
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 UniProt Primary Accession #    Q2F832 [Other Products]
 UniProt Related Accession #    P05455; Q14730; Q2F832; Q9UMH5; Q9UMH6; Q9UMH7 [Other Products]
 Molecular Weight    5,646 Da [Similar Products]
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 NCBI Official Full Name    Sjogren syndrome antigen B
 NCBI Official Synonym Full Names    Sjogren syndrome antigen B (autoantigen La)
 NCBI Official Symbol    SSB [Similar Products]
 NCBI Official Synonym Symbols   
La; LARP3
[Similar Products]
 NCBI Protein Information    lupus La protein; SS-B; autoantigen La; la autoantigen; SS-B/La protein; OTTHUMP00000163067; OTTHUMP00000204777; OTTHUMP00000204778; sjoegren syndrome type B antigen; La ribonucleoprotein domain family, member 3
 UniProt Protein Name    Sjogren syndrome antigen B
 Protein Family    Single-stranded DNA binding protein
 UniProt Entry Name    Q2F832_HUMAN
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 NCBI Summary for SSB    La is involved in diverse aspects of RNA metabolism, including binding and protecting 3-prime UUU(OH) elements of newly RNA polymerase III (see MIM 606007)-transcribed RNA, processing 5-prime and 3-prime ends of pre-tRNA precursors, acting as an RNA chaperone, and binding viral RNAs associated with hepatitis C virus. La protein was originally defined by its reactivity with autoantibodies from patients with Sjogren syndrome (MIM 270150) and systemic lupus erythematosus (SLE; MIM 152700) (Teplova et al., 2006 [PubMed 16387655]).[supplied by OMIM]
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 UniProt Comments for SSB    SSB: a nuclear protein that plays a role in the transcription of RNA polymerase III. It is most probably a transcription termination factor. Binds to the 3' termini of virtually all nascent polymerase III transcripts. It is associated with precursor forms of RNA polymerase III transcripts including tRNA and 4.5S, 5s, 7s, and 7-2 RNAs.

Protein type: Transcription initiation complex

Chromosomal Location of Human Ortholog: 2q31.1

Cellular Component: ribonucleoprotein complex; nucleus

Molecular Function: mRNA binding; protein binding; nucleotide binding; tRNA binding

Biological Process: RNA processing; histone mRNA metabolic process; tRNA modification
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 Research Articles on SSB    1. show elevated La protein expression in cervical cancer tissue and its correlation with aberrant CCND1 protein levels in cervical tumor tissue lysates
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-SSB antibodyPathways associated with anti-SSB antibody
 Reference Product  PubMed Publications
 NCL antibody  >3 publications with SSB and NCL
 Products by Pathway  Pathway Diagram
 RNA Polymerase I, RNA Polymerase III, And Mitochondrial Transcription Pathway antibodies  RNA Polymerase I, RNA Polymerase III, And Mitochondrial Transcription Pathway Diagram
 RNA Polymerase III Abortive And Retractive Initiation Pathway antibodies  RNA Polymerase III Abortive And Retractive Initiation Pathway Diagram
 RNA Polymerase III Transcription Pathway antibodies  RNA Polymerase III Transcription Pathway Diagram
 RNA Polymerase III Transcription Termination Pathway antibodies  RNA Polymerase III Transcription Termination Pathway Diagram
 Systemic Lupus Erythematosus Pathway antibodies  Systemic Lupus Erythematosus Pathway Diagram
 Systemic Lupus Erythematosus Pathway antibodies  Systemic Lupus Erythematosus Pathway Diagram
 Transcription Pathway antibodies  Transcription Pathway Diagram
Diseases associated with anti-SSB antibodyOrgans/Tissues associated with anti-SSB antibody
 Disease Name  Pubmed Publications
 Immune System Diseases Antibodies  >643 publications with SSB and Immune System Diseases
 Eye Diseases Antibodies  >321 publications with SSB and Eye Diseases
 Cardiovascular Diseases Antibodies  >210 publications with SSB and Cardiovascular Diseases
 Neoplasms Antibodies  >176 publications with SSB and Neoplasms
 Drug Toxicity Antibodies  >171 publications with SSB and Drug Toxicity
 Heart Diseases Antibodies  >170 publications with SSB and Heart Diseases
 Nervous System Diseases Antibodies  >93 publications with SSB and Nervous System Diseases
 Vascular Diseases Antibodies  >70 publications with SSB and Vascular Diseases
 Inflammation Antibodies  >53 publications with SSB and Inflammation
 Carcinoma Antibodies  >50 publications with SSB and Carcinoma
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >496 publications with SSB and Blood
 Heart Antibodies  >193 publications with SSB and Heart
 Skin Antibodies  >137 publications with SSB and Skin
 Liver Antibodies  >113 publications with SSB and Liver
 Salivary Gland Antibodies  >108 publications with SSB and Salivary Gland
 Connective Tissue Antibodies  >107 publications with SSB and Connective Tissue
 Mouth Antibodies  >87 publications with SSB and Mouth
 Lung Antibodies  >71 publications with SSB and Lung
 Muscle Antibodies  >64 publications with SSB and Muscle
 Brain Antibodies  >59 publications with SSB and Brain
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