Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
1.855.MyBioSource
Fax 1.858.633.0166    Email sales@mybiosource.com 
tel/fax
menu1 Home Products Ordering Company Help menu7
bottom
   MyBioSource rightarrow Antibody rightarrow Smad2 rightarrow Polyclonal Smad2  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Menu separator
separator
ELISA Kit ELISA Kit
CLIA Kit CLIA Kit
PCR Kit PCR Kit
Monoclonal Antibody Monoclonal Antibody
Polyclonal Antibody Polyclonal Antibody
Secondary Antibody Secondary Antibody
Antigen Antigen
Biochemical Biochemical
cDNA Clone cDNA Clone
siRNA siRNA
Peptide Peptide
Recombinant/Purified Protein Rec./Purified Protein

Custom ELISA Kit Custom ELISA Kit
Custom Protein Custom Protein
Custom Antibody Custom Antibody
Antibody Matched Pairs Antibody Matched Pairs
Antibody & Corresponding Blocking Peptide Pairs Antibody Peptide Pairs
Phospho-Specific Antibodies Phospho Antibodies
Products by Disease Products by Disease
Products by Pathway Products by Pathway
Products by Tissue Products by Tissue

arrow Advanced Search
arrow Submit Technical Q&A
arrow International Distributors
arrow Contact Us
separator
Our Best Sellers moreseparator
separator
 • Leukotriene D4 (LTD4) ELISA Kit
 • PICP ELISA Kit
 • unconjugated Rabbit Anti-human IgG Secondary Antibody
 • RBP4 Antibody
 • Charged multivesicular body protein 2b (CHMP2B) Recombinant Protein
 • Aquaporin-1 (AQP1) ELISA Kit
 • AM-2201 Biochemical
 • Avian Influenza Nonstructural Protein 1 Antibody
 • MTOR Antibody
 • SAPK-JNK Antibody
 • prolactin-releasing hormone (PRH) ELISA Kit
 • chromosome 11 open reading frame 59 (C11orf59) ELISA Kit
 • LAMA1 Antibody
 • CXCR6 Antibody
 downarrow more ...
separator
separator
DatasheetFull DatasheetPrinter Friendly DatasheetPrint This DatasheetAdd to Compare ListHave Questions? Ask UsRequest for a Quotation today

anti-Smad2 antibody :: Rabbit Smad2 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS2536165
Western Blot (WB)
Unit / Price
0.02 mL  /  $110 +1 FREE 8GB USB
0.06 mL  /  $150 +1 FREE 8GB USB
0.12 mL  /  $225 +1 FREE 8GB USB
0.2 mL  /  $360 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Smad2, Polyclonal Antibody

★Popular Item★
 Also Known As   

Smad2 Polyclonal Antibody

 Product Synonym Names    SMAD2; MADH2; MADR2; Mothers against decapentaplegic homolog 2; MAD homolog 2; Mothers against DPP homolog 2; JV18-1; Mad-related protein 2; hMAD-2; SMAD family member 2; SMAD 2; Smad2; hSMAD2
 Product Gene Name   

anti-Smad2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
Table BarTOPTable Bar
 OMIM    601366
Section Bar
 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
Section Bar
 Purity/Purification    Antigen Affinity Purified
 Concentration    1 mg/ml (lot specific)
Section Bar
 Immunogen    Synthesized peptide derived from human Smad2 around the non-phosphorylation site of S250.
 Buffer    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-101153
Section Bar
 Preparation and Storage    Store at -20 degree C. Avoid freeze / thaw cycles.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-Smad2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Table BarTOPTable Bar
 Product Categories/Family for anti-Smad2 antibody    Stem cells; Cancer; Epigenetics
 Applications Tested/Suitable for anti-Smad2 antibody   

Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA)

 Application Notes for anti-Smad2 antibody    WB: 1:500-1:2000, IHC: 1:50-1:200, ELISA: 1:5000-1:20000
Section Bar
 Western Blot (WB) of anti-Smad2 antibody    Western Blot analysis of various cells with Smad2 Polyclonal Antibody.
anti-Smad2 antibody Western Blot (WB) (WB) image
Table BarTOPTable Bar
NCBI/Uniprot data below describe general gene information for Smad2. It may not necessarily be applicable to this product.
 NCBI GI #    2967646
 NCBI GeneID    4087
 NCBI Accession #    AAC39657.1 [Other Products]
Section Bar
 UniProt Related Accession #    Q15796 [Other Products]
 Molecular Weight    Calculated MW: 52
Observed MW: 52
Table BarTOPTable Bar
 NCBI Official Full Name    Smad2
 NCBI Official Synonym Full Names    SMAD family member 2
 NCBI Official Symbol    SMAD2 [Similar Products]
 NCBI Official Synonym Symbols   
JV18; MADH2; MADR2; JV18-1; hMAD-2; hSMAD2
[Similar Products]
 NCBI Protein Information    mothers against decapentaplegic homolog 2
 UniProt Protein Name    Mothers against decapentaplegic homolog 2
 UniProt Synonym Protein Names   
JV18-1; Mad-related protein 2; hMAD-2; SMAD family member 2; SMAD 2; Smad2; hSMAD2
 Protein Family    Mothers against decapentaplegic
 UniProt Gene Name    SMAD2 [Similar Products]
 UniProt Synonym Gene Names    MADH2; MADR2; MAD homolog 2; Mothers against DPP homolog 2; hMAD-2; SMAD 2; Smad2; hSMAD2 [Similar Products]
 UniProt Entry Name    SMAD2_HUMAN
Section Bar
 NCBI Summary for Smad2    The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signal of the transforming growth factor (TGF)-beta, and thus regulates multiple cellular processes, such as cell proliferation, apoptosis, and differentiation. This protein is recruited to the TGF-beta receptors through its interaction with the SMAD anchor for receptor activation (SARA) protein. In response to TGF-beta signal, this protein is phosphorylated by the TGF-beta receptors. The phosphorylation induces the dissociation of this protein with SARA and the association with the family member SMAD4. The association with SMAD4 is important for the translocation of this protein into the nucleus, where it binds to target promoters and forms a transcription repressor complex with other cofactors. This protein can also be phosphorylated by activin type 1 receptor kinase, and mediates the signal from the activin. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, May 2012]
Section Bar
 UniProt Comments for Smad2    SMAD2: ubiquitously expressed transcription factor phosphorylated and activated by TGF-beta receptor-type kinases. Participates in a wide range of critical processes including morphogenesis, cell-fate determination, proliferation, differentiation and apoptosis. Phosphorylated Smads dimerize with collaborating Smad4 and are translocated into the nucleus, where the transcription of target genes is stimulated. Two alternatively spliced isoforms have been described.

Protein type: DNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: 18q21.1

Cellular Component: cytoplasm; cytosol; nuclear chromatin; nucleoplasm; nucleus; transcription factor complex

Molecular Function: chromatin binding; DNA binding; double-stranded DNA binding; metal ion binding; phosphatase binding; protein binding; protein heterodimerization activity; protein homodimerization activity; SMAD binding; transcription activator binding; transcription factor activity; transcription factor binding; transforming growth factor beta receptor binding; transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity; ubiquitin protein ligase binding

Biological Process: activin receptor signaling pathway; anterior/posterior pattern formation; cell fate commitment; common-partner SMAD protein phosphorylation; embryonic cranial skeleton morphogenesis; embryonic foregut morphogenesis; endoderm formation; gastrulation; gene expression; in utero embryonic development; insulin secretion; lung development; mesoderm formation; negative regulation of cell proliferation; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; negative regulation of transforming growth factor beta receptor signaling pathway; organ growth; palate development; pancreas development; paraxial mesoderm morphogenesis; pericardium development; positive regulation of BMP signaling pathway; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; post-embryonic development; primary microRNA processing; regulation of binding; regulation of transforming growth factor beta receptor signaling pathway; response to glucose stimulus; SMAD protein complex assembly; somatic stem cell maintenance; transcription initiation from RNA polymerase II promoter; transcription, DNA-dependent; transforming growth factor beta receptor signaling pathway; ureteric bud development; zygotic determination of dorsal/ventral axis
Table BarTOPTable Bar
 Research Articles on Smad2    1. Induction of neural crest genes by beta-catenin is repressed by SMAD2/SMAD3, ensuring proper lineage specification.
Table BarTOPTable Bar
 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Table BarTOPTable Bar
Products associated with anti-Smad2 antibodyPathways associated with anti-Smad2 antibody
 Reference Product  PubMed Publications
 SMAD4 antibody  >950 publications with Smad2 and SMAD4
 FOXH1 antibody  >60 publications with Smad2 and FOXH1
 ACVR1B antibody  >44 publications with Smad2 and ACVR1B
 TGFBR1 antibody  >41 publications with Smad2 and TGFBR1
 SKIL antibody  >39 publications with Smad2 and SKIL
 EP300 antibody  >14 publications with Smad2 and EP300
 UBC antibody  >10 publications with Smad2 and UBC
 CREBBP antibody  >7 publications with Smad2 and CREBBP
 ZFYVE9 antibody  >4 publications with Smad2 and ZFYVE9
 Products by Pathway  Pathway Diagram
 AGE-RAGE Signaling Pathway In Diabetic Complications antibodies  AGE-RAGE Signaling Pathway In Diabetic Complications Diagram
 AGE-RAGE Signaling Pathway In Diabetic Complications antibodies  AGE-RAGE Signaling Pathway In Diabetic Complications Diagram
 AGE/RAGE Pathway antibodies  AGE/RAGE Pathway Diagram
 Activin Signaling Pathway antibodies  Activin Signaling Pathway Diagram
 Activin Signaling Pathway antibodies  Activin Signaling Pathway Diagram
 Adherens Junction Pathway antibodies  Adherens Junction Pathway Diagram
 Adherens Junction Pathway antibodies  Adherens Junction Pathway Diagram
 Alpha6-Beta4 Integrin Signaling Pathway antibodies  Alpha6-Beta4 Integrin Signaling Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
Diseases associated with anti-Smad2 antibodyOrgans/Tissues associated with anti-Smad2 antibody
 Disease Name  Pubmed Publications
 Fibrosis Antibodies  >1034 publications with Smad2 and Fibrosis
 Carcinoma Antibodies  >414 publications with Smad2 and Carcinoma
 Disease Models, Animal Antibodies  >411 publications with Smad2 and Disease Models, Animal
 Inflammation Antibodies  >341 publications with Smad2 and Inflammation
 Kidney Diseases Antibodies  >250 publications with Smad2 and Kidney Diseases
 Liver Diseases Antibodies  >239 publications with Smad2 and Liver Diseases
 Heart Diseases Antibodies  >179 publications with Smad2 and Heart Diseases
 Breast Neoplasms Antibodies  >141 publications with Smad2 and Breast Neoplasms
 Hypertrophy Antibodies  >128 publications with Smad2 and Hypertrophy
 Liver Cirrhosis Antibodies  >123 publications with Smad2 and Liver Cirrhosis
 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >803 publications with Smad2 and Muscle
 Bone Antibodies  >539 publications with Smad2 and Bone
 Blood Antibodies  >469 publications with Smad2 and Blood
 Lung Antibodies  >469 publications with Smad2 and Lung
 Vascular Antibodies  >455 publications with Smad2 and Vascular
 Kidney Antibodies  >455 publications with Smad2 and Kidney
 Liver Antibodies  >369 publications with Smad2 and Liver
 Connective Tissue Antibodies  >319 publications with Smad2 and Connective Tissue
 Heart Antibodies  >314 publications with Smad2 and Heart
 Embryonic Tissue Antibodies  >263 publications with Smad2 and Embryonic Tissue
Table BarTOPTable Bar
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions