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anti-SKIL antibody :: Rabbit SnoN Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS151484
Unit / Price
0.1 mg  /  $365 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

SnoN (SKIL), Polyclonal Antibody

★Popular Item★
 Also Known As   

SnoN Antibody

 Product Synonym Names    SnoN; SNO; SnoA; SnoI; SnoN; SNO; Ski-like protein; Ski-related oncogene; SKI-like oncogene
 Product Gene Name   

anti-SKIL antibody

[Similar Products]
 Antibody/Peptide Pairs    SnoN peptide (MBS152549) is used for blocking the activity of SnoN antibody (MBS151484)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    165340
 3D Structure    ModBase 3D Structure for P12757
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    SnoN Antibody is affinity chromatography purified via peptide column.
 Form/Format    Liquid
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 Conjugate    Unconjugated
 Immunogen    SnoN antibody was raised against a 16 amino acid synthetic peptide from near the amino terminus of human SnoN.
 Buffer    SnoN Antibody is supplied in PBS containing 0.02% sodium azide.
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 Preparation and Storage    SnoN antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
 Other Notes    Small volumes of anti-SKIL antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-SKIL antibody

   SnoN Antibody: TGF-beta is a ubiquitously expressed cytokine that signals through the Smad protein family to regulate numerous cellular processes such as embryonic development and tumorigenesis. This signaling is negatively regulated by Ski, the mammalian homolog of the transforming protein of an avian retrovirus that induces oncogenic transformation of chicken embryo cells, and the related protein SnoN. Like Ski, SnoN functions by binding to the Smad proteins and preventing their phosphorylation, thereby inhibiting their ability to bind DNA and activate the transcription of downstream genes. SnoN is located primarily in the nucleus in cancer tissues or cells, but in the cytoplasm in normal tissues or primary epithelial cells. There are at least four alternately spliced isoforms of SnoN; SnoN antibody will recognize all isoforms (SnoN, SnoN2, SnoI, and SnoA).
 Applications Tested/Suitable for anti-SKIL antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry-Paraffin (IHC-P), Immunofluorescence (IF)

 Application Notes for anti-SKIL antibody    SnoN antibody can be used for detection of SnoN by Western blot at 0.5 - 1 mug/mL. Antibody can also be used for immunohistochemistry starting at 5 mug/mL. For immunofluorescence start at 20 mug/mL.
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 Western Blot (WB) of anti-SKIL antibody    Western blot analysis of SnoN in A431 cell lysate with SnoN antibody at (A) 0.5 and (B) 1 μg/mL.
anti-SKIL antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-SKIL antibody    Immunohistochemistry of SnoN in mouse lung tissue with SnoN antibody at 5 μg/mL.
anti-SKIL antibody Immunohistochemistry (IHC) (IHC) image
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 Immunofluorescence (IF) of anti-SKIL antibody    Immunofluorescence of SnoN in Mouse Lung cells with SnoN antibody at 20 μg/mL.
anti-SKIL antibody Immunofluorescence (IF) image
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NCBI/Uniprot data below describe general gene information for SKIL. It may not necessarily be applicable to this product.
 NCBI GI #    223029418
 NCBI GeneID    6498
 NCBI Accession #    NP_005405 [Other Products]
 NCBI GenBank Nucleotide #    NM_005414.4 [Other Products]
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 UniProt Primary Accession #    P12757 [Other Products]
 UniProt Secondary Accession #    O00464; P12756; Q07501; A6NGT1; B4DT50 [Other Products]
 UniProt Related Accession #    P12757 [Other Products]
 Molecular Weight    74,784 Da
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 NCBI Official Full Name    ski-like protein isoform 1
 NCBI Official Synonym Full Names    SKI-like proto-oncogene
 NCBI Official Symbol    SKIL [Similar Products]
 NCBI Official Synonym Symbols   
SNO; SnoA; SnoI; SnoN
[Similar Products]
 NCBI Protein Information    ski-like protein; SKI-like oncogene; ski-related oncogene snoN
 UniProt Protein Name    Ski-like protein
 UniProt Synonym Protein Names   
Ski-related oncogene; Ski-related protein
 Protein Family    Ski-like protein
 UniProt Gene Name    SKIL [Similar Products]
 UniProt Synonym Gene Names    SNO [Similar Products]
 UniProt Entry Name    SKIL_HUMAN
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 NCBI Summary for SKIL    The protein encoded by this gene is a component of the SMAD pathway, which regulates cell growth and differentiation through transforming growth factor-beta (TGFB). In the absence of ligand, the encoded protein binds to the promoter region of TGFB-responsive genes and recruits a nuclear repressor complex. TGFB signaling causes SMAD3 to enter the nucleus and degrade this protein, allowing these genes to be activated. Four transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
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 UniProt Comments for SKIL    SKIL: May have regulatory role in cell division or differentiation in response to extracellular signals. Interacts with SMAD2, SMAD3 and RNF111. Isoform 1 interacts with WWP1. Isoform SNON and isoform SNOA are widely expressed. Highest expression is found in skeletal muscle, followed by placenta and lung. Lowest expression in heart, brain and pancreas. Isoform SNOI expression is restricted to skeletal muscle. Belongs to the SKI family. 5 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 3q26

Cellular Component: nucleoplasm; PML body; protein complex; cytoplasm; acrosome; nucleus

Molecular Function: protein domain specific binding; protein binding; DNA binding; protein complex binding; chromatin binding; SMAD binding; transcription corepressor activity

Biological Process: transcription initiation from RNA polymerase II promoter; skeletal muscle development; transcription, DNA-dependent; blastocyst formation; negative regulation of transcription from RNA polymerase II promoter; response to antibiotic; regulation of apoptosis; negative regulation of cell differentiation; response to cytokine stimulus; transforming growth factor beta receptor signaling pathway; positive regulation of axonogenesis; gene expression; spermatogenesis; negative regulation of transforming growth factor beta receptor signaling pathway; cell cycle arrest; lymphocyte homeostasis
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 Research Articles on SKIL    1. The results indicate that protein ubiquitination promotes megakaryopoiesis via degrading SnoN, an inhibitor of CD61 expression, strengths the roles of ubiquitination in cellular differentiation.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-SKIL antibodyPathways associated with anti-SKIL antibody
 Reference Product  PubMed Publications
 SKI antibody  >81 publications with SKIL and SKI
 SMAD2 antibody  >39 publications with SKIL and SMAD2
 SMAD3 antibody  >33 publications with SKIL and SMAD3
 SMAD4 antibody  >25 publications with SKIL and SMAD4
 SIN3A antibody  >1 publications with SKIL and SIN3A
 Products by Pathway  Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Downregulation Of SMAD2/3:SMAD4 Transcriptional Activity Pathway antibodies  Downregulation Of SMAD2/3:SMAD4 Transcriptional Activity Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 Generic Transcription Pathway antibodies  Generic Transcription Pathway Diagram
 Loss Of Function Of SMAD2/3 In Cancer Pathway antibodies  Loss Of Function Of SMAD2/3 In Cancer Pathway Diagram
 Loss Of Function Of SMAD4 In Cancer Pathway antibodies  Loss Of Function Of SMAD4 In Cancer Pathway Diagram
 Loss Of Function Of TGFBR1 In Cancer Pathway antibodies  Loss Of Function Of TGFBR1 In Cancer Pathway Diagram
 Loss Of Function Of TGFBR2 In Cancer Pathway antibodies  Loss Of Function Of TGFBR2 In Cancer Pathway Diagram
 Regulation Of Nuclear SMAD2/3 Signaling Pathway antibodies  Regulation Of Nuclear SMAD2/3 Signaling Pathway Diagram
 SMAD2/3 MH2 Domain Mutants In Cancer Pathway antibodies  SMAD2/3 MH2 Domain Mutants In Cancer Pathway Diagram
Diseases associated with anti-SKIL antibodyOrgans/Tissues associated with anti-SKIL antibody
 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >27 publications with SKIL and Carcinoma
 Skin Diseases Antibodies  >17 publications with SKIL and Skin Diseases
 Cell Transformation, Neoplastic Antibodies  >14 publications with SKIL and Cell Transformation, Neoplastic
 Skin Neoplasms Antibodies  >9 publications with SKIL and Skin Neoplasms
 Ovarian Neoplasms Antibodies  >9 publications with SKIL and Ovarian Neoplasms
 Neoplasm Metastasis Antibodies  >7 publications with SKIL and Neoplasm Metastasis
 Breast Neoplasms Antibodies  >7 publications with SKIL and Breast Neoplasms
 Neoplasms, Experimental Antibodies  >6 publications with SKIL and Neoplasms, Experimental
 Disease Models, Animal Antibodies  >6 publications with SKIL and Disease Models, Animal
 Lung Neoplasms Antibodies  >5 publications with SKIL and Lung Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Skin Antibodies  >14 publications with SKIL and Skin
 Muscle Antibodies  >13 publications with SKIL and Muscle
 Bone Antibodies  >13 publications with SKIL and Bone
 Embryonic Tissue Antibodies  >11 publications with SKIL and Embryonic Tissue
 Liver Antibodies  >10 publications with SKIL and Liver
 Blood Antibodies  >10 publications with SKIL and Blood
 Kidney Antibodies  >9 publications with SKIL and Kidney
 Lung Antibodies  >8 publications with SKIL and Lung
 Brain Antibodies  >8 publications with SKIL and Brain
 Lymph Node Antibodies  >5 publications with SKIL and Lymph Node
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