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anti-SSTR2 antibody :: Rabbit Somatostatin Receptor 2 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS175660
Testing Data
Unit / Price
0.1 mg  /  $245 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Somatostatin Receptor 2 (SSTR2), Polyclonal Antibody

 Also Known As   

Anti-Somatostatin Receptor 2 antibody

 Product Synonym Names    Somatostatin receptor type 2(SS-2-R/SS2-R/SS2R); somatostatin receptor 2; Somatostatin receptor type 2 antibody; SRIF-1 antibody; SRIF1 antibody; SS-2-R antibody; SS2-R antibody; SS2R antibody; SSR2_HUMAN antibody; SST2 antibody; SSTR2 antibody
 Product Gene Name   

anti-SSTR2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    182452
 3D Structure    ModBase 3D Structure for P30874
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Immunogen affinity purified.
 Form/Format    Lyophilized
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 Immunogen    A synthetic peptide corresponding to a sequence in the middle region of human Somatostatin Receptor 2 (184-198aa RSNQWGRSSCTINWP), identical to the related rat and mouse sequences.
 Contents    Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
 Reconstitution    Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
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 Preparation and Storage    At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-SSTR2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-SSTR2 antibody

   Description: Rabbit IgG polyclonal antibody for Somatostatin receptor type 2(SSTR2) detection. Tested with WB in Human, Mouse, Rat.
Background: SSTR2(Somatostatin receptor type 2) is a protein that in humans is encoded by the SSTR2 gene. Somatostatin acts at many sites to inhibit the release of many hormones and other secretory proteins. The biologic effects of somatostatin are probably mediated by a family of G protein-coupled receptors that are expressed in a tissue-specific manner. SSTR2 is a member of the superfamily of receptors having seven transmembrane segments and is expressed in highest levels in cerebrum and kidney. Stable SSTR2 transfection of human pancreatic cells, which do not endogenously express SSTR2, inhibits cell proliferation, tumorigenicity, and metastasis. These effects occur as a consequence of an autocrine SSTR2-dependent loop, whereby SSTR2 induces expression of its own ligand, somatostatin.SSTR2 mRNA was variably expressed in all neuroblastoma tumors with a relevant reduction in the more advanced stage.
 Applications Tested/Suitable for anti-SSTR2 antibody   

Western Blot (WB)

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 Testing Data of anti-SSTR2 antibody    anti-SSTR2 antibody Testing Data image
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NCBI/Uniprot data below describe general gene information for SSTR2. It may not necessarily be applicable to this product.
 NCBI GI #    401126
 NCBI GeneID    6752
 NCBI Accession #    P30874.1 [Other Products]
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 UniProt Primary Accession #    P30874 [Other Products]
 UniProt Secondary Accession #    Q4VBP0; Q96GE0; Q96TF2; Q9BWH1; A8K3Y0; B2R9P7 [Other Products]
 UniProt Related Accession #    P30874 [Other Products]
 Molecular Weight    40,007 Da
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 NCBI Official Full Name    Somatostatin receptor type 2
 NCBI Official Synonym Full Names    somatostatin receptor 2
 NCBI Official Symbol    SSTR2 [Similar Products]
 NCBI Protein Information    somatostatin receptor type 2; SS2R; SRIF-1
 UniProt Protein Name    Somatostatin receptor type 2
 UniProt Synonym Protein Names   
SRIF-1
 Protein Family    Somatostatin receptor
 UniProt Gene Name    SSTR2 [Similar Products]
 UniProt Synonym Gene Names    SS-2-R; SS2-R; SS2R [Similar Products]
 UniProt Entry Name    SSR2_HUMAN
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 NCBI Summary for SSTR2    Somatostatin acts at many sites to inhibit the release of many hormones and other secretory proteins. The biologic effects of somatostatin are probably mediated by a family of G protein-coupled receptors that are expressed in a tissue-specific manner. SSTR2 is a member of the superfamily of receptors having seven transmembrane segments and is expressed in highest levels in cerebrum and kidney. [provided by RefSeq, Jul 2008]
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 UniProt Comments for SSTR2    SSTR2: Receptor for somatostatins-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and PLC via pertussis toxin insensitive as well as sensitive G proteins. In RIN-5F cells, this receptor inhibits calcium entry by suppressing voltage dependent calcium-channels. The C-terminus interacts with SHANK1 PDZ domain. Cerebrum and kidney. In lesser amounts in jejunum, colon and liver. Belongs to the G-protein coupled receptor 1 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: GPCR, family 1; Membrane protein, multi-pass; Receptor, GPCR; Membrane protein, integral

Chromosomal Location of Human Ortholog: 17q24

Cellular Component: neuron projection; integral to plasma membrane; cytoplasm; plasma membrane

Molecular Function: neuropeptide binding; somatostatin receptor activity; protein binding; PDZ domain binding

Biological Process: peristalsis; regulation of muscle contraction; response to starvation; synaptic transmission; negative regulation of cell proliferation; G-protein signaling, coupled to cyclic nucleotide second messenger; cell-cell signaling; neuropeptide signaling pathway; digestion; forebrain development; cerebellum development; spermatogenesis; G-protein signaling, adenylate cyclase inhibiting pathway; response to nutrient
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 Research Articles on SSTR2    1. Filamin A is involved in SST2 stabilization and signaling in tumoral somatotrophs, playing both a structural and functional role.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-SSTR2 antibodyPathways associated with anti-SSTR2 antibody
 Reference Product  PubMed Publications
 SSTR3 antibody  >163 publications with SSTR2 and SSTR3
 SST antibody  >110 publications with SSTR2 and SST
 POMC antibody  >12 publications with SSTR2 and POMC
 NPY antibody  >1 publications with SSTR2 and NPY
 Products by Pathway  Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 G Alpha (i) Signalling Events Pathway antibodies  G Alpha (i) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 GPCRs, Class A Rhodopsin-like Pathway antibodies  GPCRs, Class A Rhodopsin-like Pathway Diagram
 GPCRs, Other Pathway antibodies  GPCRs, Other Pathway Diagram
 Gastric Acid Secretion Pathway antibodies  Gastric Acid Secretion Pathway Diagram
 Gastric Acid Secretion Pathway antibodies  Gastric Acid Secretion Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
Diseases associated with anti-SSTR2 antibodyOrgans/Tissues associated with anti-SSTR2 antibody
 Disease Name  Pubmed Publications
 Neuroendocrine Tumors Antibodies  >90 publications with SSTR2 and Neuroendocrine Tumors
 Nervous System Diseases Antibodies  >89 publications with SSTR2 and Nervous System Diseases
 Adenocarcinoma Antibodies  >60 publications with SSTR2 and Adenocarcinoma
 Pancreatic Neoplasms Antibodies  >51 publications with SSTR2 and Pancreatic Neoplasms
 Disease Models, Animal Antibodies  >35 publications with SSTR2 and Disease Models, Animal
 Liver Diseases Antibodies  >29 publications with SSTR2 and Liver Diseases
 Liver Neoplasms Antibodies  >28 publications with SSTR2 and Liver Neoplasms
 Breast Neoplasms Antibodies  >23 publications with SSTR2 and Breast Neoplasms
 Carcinoma, Hepatocellular Antibodies  >15 publications with SSTR2 and Carcinoma, Hepatocellular
 Neoplasm Metastasis Antibodies  >14 publications with SSTR2 and Neoplasm Metastasis
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >129 publications with SSTR2 and Brain
 Thyroid Antibodies  >36 publications with SSTR2 and Thyroid
 Kidney Antibodies  >35 publications with SSTR2 and Kidney
 Eye Antibodies  >13 publications with SSTR2 and Eye
 Lymph Node Antibodies  >12 publications with SSTR2 and Lymph Node
 Bone Antibodies  >8 publications with SSTR2 and Bone
 Spleen Antibodies  >4 publications with SSTR2 and Spleen
 Testis Antibodies  >3 publications with SSTR2 and Testis
 Mammary Gland Antibodies  >1 publications with SSTR2 and Mammary Gland
 Pineal Gland Antibodies  >1 publications with SSTR2 and Pineal Gland
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