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anti-SORD antibody :: Goat Sorbitol Dehydrogenase Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS420481
Western Blot (WB)
Unit / Price
0.1 mg  /  $300 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Sorbitol Dehydrogenase (SORD), Polyclonal Antibody

 Also Known As   

Goat anti-Sorbitol Dehydrogenase Antibody

 Product Synonym Names    sorbitol dehydrogenase; SORD; SORD1; sorbitol dehydrogenase antibody; SORD antibody; SORD1 antibody; Sorbitol Dehydrogenase; Sorbitol Dehydrogenase
 Product Gene Name   

anti-SORD antibody

[Similar Products]
 Antibody/Peptide Pairs    Sorbitol Dehydrogenase peptide (MBS426174) is used for blocking the activity of Sorbitol Dehydrogenase antibody (MBS420481)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    KIMLKCDPSD QNP
 OMIM    182500
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 Clonality    Polyclonal
 Host    Goat
 Species Reactivity    Tested: Mouse; Expected from sequence similarity: Human, Mouse, Rat, Dog
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 Purity/Purification    Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
 Form/Format    Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
 Concentration    100ug specific antibody in 200ul (lot specific)
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 Immunogen    Peptide with sequence KIMLKCDPSDQNP, from the C Terminus of the protein sequence according to NP_003095.2.
 Epitope    C Terminus
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 Preparation and Storage    Aliquot and store at -20 degree C. Minimize freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of anti-SORD antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-SORD antibody   

Peptide ELISA (EIA), Western Blot (WB)

 Application Notes for anti-SORD antibody    Peptide ELISA: Antibody detection limit dilution 1: 16000.
Western Blot: Approx 38kDa band observed in Mouse Kidney lysates (calculated MW of 38.3kDa according to NP_003095.1). Recommended concentration: 0.1-0.3ug/ml. A minor band of unknown identity was also consistently observed at 48kDa. This band was successfully blocked by incubation with the immunising peptide.
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 Western Blot (WB) of anti-SORD antibody    (0.1ug/ml) staining of Mouse Kidney lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
anti-SORD antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for SORD. It may not necessarily be applicable to this product.
 NCBI GI #    156627571
 NCBI GeneID    6652
 NCBI Accession #    NP_003095.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_003104.5 [Other Products]
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 UniProt Secondary Accession #    Q16682; Q9UMD6; B2R655; B7Z3A6; J3JZZ5 [Other Products]
 UniProt Related Accession #    Q00796 [Other Products]
 Molecular Weight    10,812 Da
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 NCBI Official Full Name    sorbitol dehydrogenase
 NCBI Official Synonym Full Names    sorbitol dehydrogenase
 NCBI Official Symbol    SORD [Similar Products]
 NCBI Official Synonym Symbols   
SORD1; HEL-S-95n
[Similar Products]
 NCBI Protein Information    sorbitol dehydrogenase
 UniProt Protein Name    Sorbitol dehydrogenase
 UniProt Synonym Protein Names   
L-iditol 2-dehydrogenase
 Protein Family    Sorbitol dehydrogenase
 UniProt Gene Name    SORD [Similar Products]
 UniProt Entry Name    DHSO_HUMAN
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 NCBI Summary for SORD    Sorbitol dehydrogenase (SORD; EC 1.1.1.14) catalyzes the interconversion of polyols and their corresponding ketoses, and together with aldose reductase (ALDR1; MIM 103880), makes up the sorbitol pathway that is believed to play an important role in the development of diabetic complications (summarized by Carr and Markham, 1995 [PubMed 8535074]). The first reaction of the pathway (also called the polyol pathway) is the reduction of glucose to sorbitol by ALDR1 with NADPH as the cofactor. SORD then oxidizes the sorbitol to fructose using NAD(+) cofactor.[supplied by OMIM, Jul 2010]
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 UniProt Comments for SORD    SORD: Converts sorbitol to fructose. Part of the polyol pathway that plays an important role in sperm physiology. May play a role in the sperm motility by providing an energetic source for sperm. Belongs to the zinc-containing alcohol dehydrogenase family.

Protein type: Oxidoreductase; Carbohydrate Metabolism - fructose and mannose; EC 1.1.1.14

Chromosomal Location of Human Ortholog: 15q15.3

Cellular Component: cytosol; extracellular space; membrane; mitochondrial membrane

Molecular Function: carbohydrate binding; D-xylulose reductase activity; identical protein binding; L-iditol 2-dehydrogenase activity; NAD binding; zinc ion binding

Biological Process: fructose biosynthetic process; glucose metabolic process; glucuronate catabolic process to xylulose 5-phosphate; L-xylitol catabolic process; L-xylitol metabolic process; response to cadmium ion; response to copper ion; response to drug; response to hormone stimulus; response to nutrient levels; response to osmotic stress; sorbitol catabolic process; sperm motility
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Product References and Citations for anti-SORD antibody

   Cao W, Aghajanian HK, Haig-Ladewig LA, Gerton GL.; Sorbitol can fuel mouse sperm motility and protein tyrosine phosphorylation via sorbitol dehydrogenase.; Biol Reprod.2009 Jan;80(1): 124-33.; Pubmed 18799757
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 Research Articles on SORD    1. One of the most striking changes involved sorbitol dehydrogenase, a key enzyme in the polyol pathway. Validation studies revealed dramatically increased sorbitol dehydrogenase concentrations and activity in adenomas and cancer cell lines, along with important changes in the expression of other enzymes in the same (AKR1B1) and related (KHK) pathways.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-SORD antibodyDiseases associated with anti-SORD antibody
 Products by Pathway  Pathway Diagram
 Catabolism Of Glucuronate To Xylulose-5-phosphate Pathway antibodies  Catabolism Of Glucuronate To Xylulose-5-phosphate Pathway Diagram
 Fructose And Mannose Metabolism Pathway antibodies  Fructose And Mannose Metabolism Pathway Diagram
 Fructose And Mannose Metabolism Pathway antibodies  Fructose And Mannose Metabolism Pathway Diagram
 Fructose Biosynthesis Pathway antibodies  Fructose Biosynthesis Pathway Diagram
 Fructose Metabolism Pathway antibodies  Fructose Metabolism Pathway Diagram
 Glucuronate Pathway (uronate Pathway) antibodies  Glucuronate Pathway (uronate Pathway) Diagram
 Glucuronate Pathway (uronate Pathway) antibodies  Glucuronate Pathway (uronate Pathway) Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Carbohydrates Pathway antibodies  Metabolism Of Carbohydrates Pathway Diagram
 Disease Name  Pubmed Publications
 Liver Diseases Antibodies  >2 publications with SORD and Liver Diseases
 Hyperglycemia Antibodies  >1 publications with SORD and Hyperglycemia
 Liver Cirrhosis Antibodies  >1 publications with SORD and Liver Cirrhosis
 Neoplasms, Experimental Antibodies  >1 publications with SORD and Neoplasms, Experimental
 Lung Neoplasms Antibodies  >1 publications with SORD and Lung Neoplasms
 Carcinoma, Hepatocellular Antibodies  >1 publications with SORD and Carcinoma, Hepatocellular
 Liver Neoplasms Antibodies  >1 publications with SORD and Liver Neoplasms
 Kidney Diseases Antibodies  >1 publications with SORD and Kidney Diseases
Organs/Tissues associated with anti-SORD antibody
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >12 publications with SORD and Blood
 Brain Antibodies  >8 publications with SORD and Brain
 Eye Antibodies  >4 publications with SORD and Eye
 Kidney Antibodies  >3 publications with SORD and Kidney
 Liver Antibodies  >3 publications with SORD and Liver
 Vascular Antibodies  >2 publications with SORD and Vascular
 Muscle Antibodies  >2 publications with SORD and Muscle
 Larynx Antibodies  >1 publications with SORD and Larynx
 Testis Antibodies  >1 publications with SORD and Testis
 Thyroid Antibodies  >1 publications with SORD and Thyroid
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