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anti-SYK antibody :: Goat Spleen tyrosine kinase/SYK Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS421218
Western Blot (WB)
Unit / Price
0.1 mg  /  $300 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Spleen tyrosine kinase/SYK, Polyclonal Antibody

 Also Known As   

Goat anti-Spleen tyrosine kinase/SYK Antibody

 Product Synonym Names    SYK; spleen tyrosine kinase; HGNC: 11491; DKFZp313N1010; FLJ25043; FLJ37489; OTTHUMP00000021628; OTTHUMP00000021629; SYK antibody; spleen tyrosine kinase antibody; HGNC: 11491 antibody; DKFZp313N1010 antibody; FLJ25043 antibody; FLJ37489 antibody; OTTHUMP00000021628 antibody; OTTHUMP00000021629 antibody; Spleen tyrosine kinase; Spleen tyrosine kinase / SYK
 Product Gene Name   

anti-SYK antibody

[Similar Products]
 Antibody/Peptide Pairs    Spleen tyrosine kinase / SYK peptide (MBS425490) is used for blocking the activity of Spleen tyrosine kinase/SYK antibody (MBS421218)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    KYLQQNRHVK DKN
 OMIM    600085
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 Clonality    Polyclonal
 Host    Goat
 Species Reactivity    Tested: Human; Expected from sequence similarity: Human, Mouse, Rat, Dog, Pig, Cow
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 Purity/Purification    Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
 Form/Format    Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
 Concentration    100ug specific antibody in 200ul (lot specific)
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 Immunogen    Peptide with sequence C-KYLQQNRHVKDKN, from the internal region of the protein sequence according to NP_003168.2; NP_001128524.1.
 Epitope    Internal region
 Note    This antibody is expected to recognise both reported isoforms (NP_003168.2; NP_001128524.1). Reported pairs of variants represent identical proteins (NP_003168.2 and NP_001167638.1; NP_001128524.1 and NP_001167639.1).
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 Preparation and Storage    Aliquot and store at -20 degree C. Minimize freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of anti-SYK antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-SYK antibody   

Peptide ELISA (EIA), Western Blot (WB)

 Application Notes for anti-SYK antibody    Peptide ELISA: Antibody detection limit dilution 1: 16000.
Western Blot: Approx 70kDa band observed in Human Bone marrow, Lymph Node, and Spleen lysates (calculated MW of 72.1kDa according to NP_003168.2). Recommended concentration: 1-3ug/ml.
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 Western Blot (WB) of anti-SYK antibody    (1ug/ml) staining of Human Spleen lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
anti-SYK antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for SYK. It may not necessarily be applicable to this product.
 NCBI GI #    21361553
 NCBI GeneID    6850
 NCBI Accession #    NP_003168.2 [Other Products]
 NCBI Related Accession #    NP_001128524.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_003177.6 [Other Products]
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 UniProt Related Accession #    P43405 [Other Products]
 Molecular Weight    69,510 Da
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 NCBI Official Full Name    tyrosine-protein kinase SYK isoform Syk(L)
 NCBI Official Synonym Full Names    spleen tyrosine kinase
 NCBI Official Symbol    SYK [Similar Products]
 NCBI Official Synonym Symbols   
p72-Syk
[Similar Products]
 NCBI Protein Information    tyrosine-protein kinase SYK
 UniProt Protein Name    Tyrosine-protein kinase SYK
 UniProt Synonym Protein Names   
Spleen tyrosine kinase; p72-Syk
 Protein Family    Tyrosine-protein kinase
 UniProt Gene Name    SYK [Similar Products]
 UniProt Entry Name    KSYK_HUMAN
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 NCBI Summary for SYK    This gene encodes a member of the family of non-receptor type Tyr protein kinases. This protein is widely expressed in hematopoietic cells and is involved in coupling activated immunoreceptors to downstream signaling events that mediate diverse cellular responses, including proliferation, differentiation, and phagocytosis. It is thought to be a modulator of epithelial cell growth and a potential tumour suppressor in human breast carcinomas. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]
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 UniProt Comments for SYK    Syk: a cytoplasmic tyrosine kinase of the SYK family containing two SH2 domains. Plays a central role in the B cell receptor (BCR) response. An upstream activator of the PI3K, PLCgamma2, and Rac/cdc42 pathways in the BCR response. Required for the sequential events of Fc gamma IIa receptor-mediated phagocytosis. Expression highest in murine spleen, heart, mammary gland and thymus. Two splice variant isoforms have been described.

Protein type: Kinase, protein; Protein kinase, TK; EC 2.7.10.2; Protein kinase, tyrosine (non-receptor); TK group; Syk family

Chromosomal Location of Human Ortholog: 9q22

Cellular Component: B cell receptor complex; cytoplasm; cytosol; extrinsic to internal side of plasma membrane; nucleus; plasma membrane; protein complex; T cell receptor complex

Molecular Function: ATP binding; integrin binding; non-membrane spanning protein tyrosine kinase activity; protein binding; protein kinase activity; protein kinase binding; protein serine/threonine kinase activity; protein-tyrosine kinase activity; receptor signaling protein tyrosine kinase activity

Biological Process: activation of JNK activity; adaptive immune response; angiogenesis; B cell receptor signaling pathway; beta selection; blood vessel morphogenesis; cell proliferation; defense response to bacterium; inflammatory response; innate immune response; integrin-mediated signaling pathway; leukocyte activation during immune response; leukocyte adhesion; leukotriene biosynthetic process; lymph vessel development; macrophage activation during immune response; neutrophil activation during immune response; neutrophil chemotaxis; organ morphogenesis; peptidyl-serine phosphorylation; platelet activation; positive regulation of alpha-beta T cell differentiation; positive regulation of alpha-beta T cell proliferation; positive regulation of B cell differentiation; positive regulation of bone resorption; positive regulation of calcium-mediated signaling; positive regulation of cell adhesion mediated by integrin; positive regulation of cytokine secretion; positive regulation of gamma-delta T cell differentiation; positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process; positive regulation of interferon type I production; positive regulation of interleukin-3 biosynthetic process; positive regulation of mast cell degranulation; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of receptor internalization; protein amino acid phosphorylation; receptor internalization; regulation of neutrophil degranulation; regulation of phagocytosis; regulation of superoxide release; regulation of transcription factor activity; serotonin secretion by platelet; stimulatory C-type lectin receptor signaling pathway; transcription factor import into nucleus; transmembrane receptor protein tyrosine kinase signaling pathway; viral reproduction
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 Research Articles on SYK    1. Results suggest that the activated Syk-mediated TRAF6 pathway leads to aberrant activation of B cells in SLE.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-SYK antibodyPathways associated with anti-SYK antibody
 Reference Product  PubMed Publications
 LCK antibody  >146 publications with SYK and LCK
 LAT antibody  >144 publications with SYK and LAT
 CBL antibody  >129 publications with SYK and CBL
 GRB2 antibody  >84 publications with SYK and GRB2
 BLNK antibody  >79 publications with SYK and BLNK
 VAV1 antibody  >65 publications with SYK and VAV1
 TYROBP antibody  >39 publications with SYK and TYROBP
 CBLB antibody  >15 publications with SYK and CBLB
 HCLS1 antibody  >10 publications with SYK and HCLS1
 LCP2 antibody  >2 publications with SYK and LCP2
 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Alpha-synuclein Signaling Pathway antibodies  Alpha-synuclein Signaling Pathway Diagram
 Antigen Activates B Cell Receptor (BCR) Leading To Generation Of Second Messengers Pathway antibodies  Antigen Activates B Cell Receptor (BCR) Leading To Generation Of Second Messengers Pathway Diagram
 Atypical NF-kappaB Pathway antibodies  Atypical NF-kappaB Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 BCR Signaling Pathway antibodies  BCR Signaling Pathway Diagram
 C-type Lectin Receptors (CLRs) Pathway antibodies  C-type Lectin Receptors (CLRs) Pathway Diagram
 CLEC7A (Dectin-1) Signaling Pathway antibodies  CLEC7A (Dectin-1) Signaling Pathway Diagram
Diseases associated with anti-SYK antibodyOrgans/Tissues associated with anti-SYK antibody
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >368 publications with SYK and Inflammation
 Necrosis Antibodies  >209 publications with SYK and Necrosis
 Disease Models, Animal Antibodies  >115 publications with SYK and Disease Models, Animal
 Lung Diseases Antibodies  >80 publications with SYK and Lung Diseases
 Breast Neoplasms Antibodies  >56 publications with SYK and Breast Neoplasms
 Cell Transformation, Neoplastic Antibodies  >35 publications with SYK and Cell Transformation, Neoplastic
 Edema Antibodies  >31 publications with SYK and Edema
 Arthritis, Experimental Antibodies  >30 publications with SYK and Arthritis, Experimental
 Hemorrhage Antibodies  >27 publications with SYK and Hemorrhage
 Liver Diseases Antibodies  >27 publications with SYK and Liver Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >1574 publications with SYK and Blood
 Spleen Antibodies  >628 publications with SYK and Spleen
 Bone Antibodies  >281 publications with SYK and Bone
 Bone Marrow Antibodies  >229 publications with SYK and Bone Marrow
 Lung Antibodies  >116 publications with SYK and Lung
 Skin Antibodies  >74 publications with SYK and Skin
 Liver Antibodies  >71 publications with SYK and Liver
 Lymph Node Antibodies  >70 publications with SYK and Lymph Node
 Lymph Antibodies  >69 publications with SYK and Lymph
 Nerve Antibodies  >64 publications with SYK and Nerve
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