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anti-SRSF1 antibody :: Rabbit Splicing Factor, Arginine/Serine-Rich 1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS617819 anti-SRSF1 antibody
Unit / Price
0.05 mg  /  $310 +1 FREE 8GB USB
0.1 mg  /  $480 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Splicing Factor, Arginine/Serine-Rich 1 (SRSF1), Polyclonal Antibody

 Also Known As   

Splicing Factor, Arginine/Serine-Rich 1 (SFRS1, Alternate splicing factor)

 Product Synonym Names    Anti -Splicing Factor, Arginine/Serine-Rich 1 (SFRS1, Alternate splicing factor)
 Product Gene Name   

anti-SRSF1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 17; NC_000017.10 (56078280..56084707, complement). Location: 17q22
 OMIM    600812
 3D Structure    ModBase 3D Structure for Q07955
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Rodent
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 Specificity    Recognizes Splicing Factor, Arginine/Serine-Rich 1. Crossreacts with SFRS9. Species Crossreactivity: Human and rodent.
 Purity/Purification    Affinity Purified
Purified by immunoaffinity chromatography.
 Form/Format    Supplied as a liquid in PBS, pH 7.2, sodium azide before the addition of glycerol to 40%.
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 Immunogen    Synthetic peptide corresponding to LDNTKFRSHEGET of human SFRS1 (KLH). MW: 27.7kD.
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 Preparation and Storage    May be stored at 4 degree C for short-term only. For long-term storage, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
 Other Notes    Small volumes of anti-SRSF1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-SRSF1 antibody    Antibodies; Abs to Splicing Factors
 Applications Tested/Suitable for anti-SRSF1 antibody   

ELISA (EL/EIA)

 Application Notes for anti-SRSF1 antibody    Suitable for use in ELISA.
Dilution: ELISA (Serum Titer): 1:250,000
Western Blot: Preliminary results: Human placenta 50, 65kD, Human cerebellum 50kD
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NCBI/Uniprot data below describe general gene information for SRSF1. It may not necessarily be applicable to this product.
 NCBI GI #    16307434
 NCBI GeneID    6426
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 UniProt Primary Accession #    Q07955 [Other Products]
 UniProt Secondary Accession #    Q13809; B2R6Z7; D3DTZ3 [Other Products]
 UniProt Related Accession #    Q07955; Q59FA2 [Other Products]
 Molecular Weight    27,745 Da [Similar Products]
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 NCBI Official Full Name    Splicing factor, arginine/serine-rich 1
 NCBI Official Synonym Full Names    serine/arginine-rich splicing factor 1
 NCBI Official Symbol    SRSF1 [Similar Products]
 NCBI Official Synonym Symbols   
ASF; SF2; SFRS1; SF2p33; SRp30a; MGC5228; FLJ53078
[Similar Products]
 NCBI Protein Information    serine/arginine-rich splicing factor 1; ASF-1; splicing factor 2; SR splicing factor 1; alternative-splicing factor 1; splicing factor, arginine/serine-rich 1; pre-mRNA-splicing factor SF2, P33 subunit
 UniProt Protein Name    Serine/arginine-rich splicing factor 1
 UniProt Synonym Protein Names   
Alternative-splicing factor 1; ASF-1; Splicing factor, arginine/serine-rich 1; pre-mRNA-splicing factor SF2, P33 subunit
 Protein Family    Splicing factor
 UniProt Gene Name    SRSF1 [Similar Products]
 UniProt Synonym Gene Names    ASF; SF2; SF2P33; SFRS1 [Similar Products]
 UniProt Entry Name    SRSF1_HUMAN
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 NCBI Summary for SRSF1    This gene encodes a member of the arginine/serine-rich splicing factor protein family, and functions in both constitutive and alternative pre-mRNA splicing. The protein binds to pre-mRNA transcripts and components of the spliceosome, and can either activate or repress splicing depending on the location of the pre-mRNA binding site. The protein's ability to activate splicing is regulated by phosphorylation and interactions with other splicing factor associated proteins. Multiple transcript variants encoding different isoforms have been found for this gene. In addition, a pseudogene of this gene has been found on chromosome 13. [provided by RefSeq]
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 UniProt Comments for SRSF1    SF2: a serine-arginine-rich splicing regulatory protein. Plays a role in preventing exon skipping, ensuring the accuracy of splicing and regulating alternative splicing. Interacts with other spliceosomal components, via the RS domains, to form a bridge between the 5' and 3' splice site binding components, U1 snRNP and U2AF. Can stimulate binding of U1 snRNP to a 5'-splice-site-containing pre-mRNA. Extensively phosphorylated on serine residues in the serine-arginine rich region. Three splice variant isoforms have been described. ASF/SF2 splicing enhancer (ASE) which can specifically activate ASE-dependent splicing. Isoform ASF-2 and isoform ASF-3 act as splicing repressors.

Protein type: RNA splicing; RNA-binding; Spliceosome

Chromosomal Location of Human Ortholog: 17q22

Cellular Component: nucleoplasm; cytoplasm; nuclear speck; nucleus

Molecular Function: mRNA binding; RS domain binding; protein binding; RNA binding; nucleotide binding

Biological Process: transcription from RNA polymerase II promoter; in utero embryonic development; RNA splicing; regulation of mRNA stability; regulation of translation; nuclear mRNA splicing, via spliceosome; nuclear mRNA 5'-splice site recognition; mRNA splice site selection; regulation of nuclear mRNA splicing, via spliceosome; mRNA export from nucleus; regulation of transcription, DNA-dependent; gene expression; mRNA 3'-end processing; mRNA processing; termination of RNA polymerase II transcription; cardiac muscle contraction
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 Research Articles on SRSF1    1. Findings show that oncogenic factors activating the phosphoinositide 3-kinase/Akt pathway can regulate alternative splicing of Casp9 via a coordinated mechanism involving the phosphorylation of SRp30a.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-SRSF1 antibodyPathways associated with anti-SRSF1 antibody
 Reference Product  PubMed Publications
 SRPK1 antibody  >3 publications with SRSF1 and SRPK1
 Products by Pathway  Pathway Diagram
 Cleavage Of Growing Transcript In The Termination Region Pathway antibodies  Cleavage Of Growing Transcript In The Termination Region Pathway Diagram
 Formation And Maturation Of MRNA Transcript Pathway antibodies  Formation And Maturation Of MRNA Transcript Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 Processing Of Capped Intron-Containing Pre-mRNA Pathway antibodies  Processing Of Capped Intron-Containing Pre-mRNA Pathway Diagram
 RNA Polymerase II Transcription Pathway antibodies  RNA Polymerase II Transcription Pathway Diagram
 RNA Polymerase II Transcription Termination Pathway antibodies  RNA Polymerase II Transcription Termination Pathway Diagram
 Spliceosome Pathway antibodies  Spliceosome Pathway Diagram
 Spliceosome Pathway antibodies  Spliceosome Pathway Diagram
 Transcription Pathway antibodies  Transcription Pathway Diagram
 Transport Of Mature Transcript To Cytoplasm Pathway antibodies  Transport Of Mature Transcript To Cytoplasm Pathway Diagram
Diseases associated with anti-SRSF1 antibodyOrgans/Tissues associated with anti-SRSF1 antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >4 publications with SRSF1 and Neoplasms
 Carcinoma Antibodies  >3 publications with SRSF1 and Carcinoma
 Lung Neoplasms Antibodies  >2 publications with SRSF1 and Lung Neoplasms
 Nervous System Diseases Antibodies  >1 publications with SRSF1 and Nervous System Diseases
 Cardiovascular Diseases Antibodies  >1 publications with SRSF1 and Cardiovascular Diseases
 Adenoma Antibodies  >1 publications with SRSF1 and Adenoma
 Kidney Neoplasms Antibodies  >1 publications with SRSF1 and Kidney Neoplasms
 Neoplasms, Experimental Antibodies  >1 publications with SRSF1 and Neoplasms, Experimental
 Gastrointestinal Diseases Antibodies  >1 publications with SRSF1 and Gastrointestinal Diseases
 Atrophy Antibodies  >1 publications with SRSF1 and Atrophy
 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >2 publications with SRSF1 and Lung
 Heart Antibodies  >1 publications with SRSF1 and Heart
 Intestine Antibodies  >1 publications with SRSF1 and Intestine
 Brain Antibodies  >1 publications with SRSF1 and Brain
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