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anti-Sqstm1 antibody :: Rabbit Sqstm1 (S351) Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS9212103
Western Blot (WB)
Unit / Price
0.08 mL  /  $150 +1 FREE 8GB USB
0.4 mL  /  $340 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Sqstm1 (S351), Polyclonal Antibody

★Popular Item★
 Also Known As   

Sqstm1 (S351) Antibody

 Product Synonym Names    Sequestosome-1; STONE14; Ubiquitin-binding protein p62; Sqstm1; A170; STAP
 Product Gene Name   

anti-Sqstm1 antibody

[Similar Products]
 Antibody/Peptide Pairs    Sqstm1 (S351) peptide (MBS9229323) is used for blocking the activity of Sqstm1 (S351) antibody (MBS9212103)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 3D Structure    ModBase 3D Structure for Q64337
 Clonality    Polyclonal
 Isotype    Rabbit Ig
 Host    Rabbit
 Species Reactivity    Human, mouse (Predicted Reactivity: Rat)
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 Specificity    This Phospho-Sqstm1(S351) antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 346-379 amino acids from the human region of human Phospho-Sqstm1(S351).
 Purity/Purification    Purified Rabbit Polyclonal Antibody (Pab)
 Form/Format    Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
 Concentration    Vial Concentration: 0.37 (lot specific)
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 Crown Antibody    Yes
 Cellular Location    Cytoplasm. Late endosome. Nucleus. Endoplasmic reticulum. Lysosome. Cytoplasmic vesicle, autophagosome. Cytoplasm, P-body. Note=Sarcomere. In cardiac muscles localizes to the sarcomeric band. May also localize to the hepatocellular carcinoma. Colocalizes with TRIM13 in the perinuclear endoplasmic reticulum (By similarity). Commonly found in inclusion bodies containing polyubiquitinated protein aggregates (By similarity) Co-localizes with TRIM5 in the cytoplasmic bodies (By similarity)
 Tissue Location    Widely expressed.
 Antigen Source    HUMAN
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 Preparation and Storage    Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
 Other Notes    Small volumes of anti-Sqstm1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-Sqstm1 antibody

   Required both for the formation and autophagic degradation of polyubiquitin-containing bodies, called ALIS (aggresome-like induced structures). Links ALIS to the autophagic machinery via direct interaction with MAP1 LC3 family members. May regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1. May play a role in titin/TTN downstream signaling in muscle cells. May regulate signaling cascades through ubiquitination. May be involved in cell differentiation, apoptosis, immune response and regulation of K(+) channels. Adapter that mediates the interaction between TRAF6 and CYLD.

Function Autophagy receptor that interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family. Required both for the formation and autophagic degradation of polyubiquitin-containing bodies, called ALIS (aggresome-like induced structures) and links ALIS to the autophagic machinery. Involved in midbody ring degradation. May regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin- 1. May play a role in titin/TTN downstream signaling in muscle cells. May regulate signaling cascades through ubiquitination. May be involved in cell differentiation, apoptosis, immune response and regulation of K(+) channels. Adapter that mediates the interaction between TRAF6 and CYLD.
 Product Categories/Family for anti-Sqstm1 antibody    Crown Antibodies; Cell Biology; Signal Transduction; Amyotrophic Lateral Sclerosis (ALS)
 Applications Tested/Suitable for anti-Sqstm1 antibody   

Western Blot (WB), ELISA (EIA)

 Application Notes for anti-Sqstm1 antibody    WB~~1:1000
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 Western Blot (WB) of anti-Sqstm1 antibody    Western blot analysis of lysates from Hela cell line and mouse liver tissue lysate(from left to right), using Sqstm1(S351) Antibody. MBS9212103 was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody. Lysates at 35ug per lane.
anti-Sqstm1 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for Sqstm1. It may not necessarily be applicable to this product.
 NCBI GI #    595582170
 NCBI GeneID    18412
 NCBI Accession #    NP_001277698.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001290769.1 [Other Products]
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 UniProt Primary Accession #    Q64337 [Other Products]
 UniProt Secondary Accession #    Q99JM8 [Other Products]
 UniProt Related Accession #    Q64337 [Other Products]
 Molecular Weight    48163
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 NCBI Official Full Name    sequestosome-1 isoform 2
 NCBI Official Synonym Full Names    sequestosome 1
 NCBI Official Symbol    Sqstm1 [Similar Products]
 NCBI Official Synonym Symbols   
Osi; p62; A170; STAP; OSF-6; STONE14
[Similar Products]
 NCBI Protein Information    sequestosome-1
 UniProt Protein Name    Sequestosome-1
 UniProt Synonym Protein Names   
STONE14; Ubiquitin-binding protein p62
 Protein Family    Sequestosome
 UniProt Gene Name    Sqstm1 [Similar Products]
 UniProt Synonym Gene Names    A170; STAP [Similar Products]
 UniProt Entry Name    SQSTM_MOUSE
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 UniProt Comments for Sqstm1    SQSTM1: an adapter protein which binds ubiquitin, shuttling proteins to the proteasome. Co-localizes along with the E3 ubiquitin ligase, TRAF6, to aggregates from Alzheimer's disease brains but not in control brain. May regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1. May play a role in titin downstream signaling in muscle cells. May regulate signaling cascades through ubiquitination. May be involved in cell differentiation, apoptosis, immune response and regulation of K(+) channels. Forms ternary complexes with PKCZ and Kv-beta2 or PKCZ and GABBR3. Also interacts with KCNAB1, GABRR1, GABRR2 and GABRR3. Interacts with EBI3, LCK, RASA1, PKCZ , PKCI, NR2F2, NTRK1, NTRK2, NTRK3, NBR1, MEK5, TRIM55 and MAPKAPK5. Interacts with the proteasome subunits PSMD4 and PSMC2. Interacts with K63- polyubiquitinated MAPT/TAU. Interacts with IKBKB through PRKCZ and PRKCI. Interacts with NGFR through TRAF6 and bridges that complex to NTRK1. Forms a complex with MEK5 and PRKCZ or PRKCI. Component of a ternary complex with PAWR and PRKCZ. Upon TNF-alpha stimulation, interacts with RIPK1 problably bridging IKBKB to the TNF-R1 complex composed of TNF-R1/TNFRSF1A, TRADD and RIPK1. Forms a complex with JUB/Ajuba, PRKCZ and TRAF6. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Ubiquitin conjugating system; Autophagy; Nuclear receptor co-regulator

Cellular Component: PML body; lysosome; endoplasmic reticulum; cytoplasm; autophagic vacuole; inclusion body; cytoplasmic vesicle; nucleus; endosome

Molecular Function: identical protein binding; protein binding; ubiquitin binding; protein homodimerization activity; protein kinase C binding; zinc ion binding; metal ion binding; transcription cofactor activity; SH2 domain binding; protein kinase binding

Biological Process: ubiquitin-dependent protein catabolic process; apoptosis; protein heterooligomerization; immune system process; autophagy; positive regulation of protein amino acid phosphorylation; cell differentiation; regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of macroautophagy
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Product References and Citations for anti-Sqstm1 antibody

   Ishii T.,et al.Biochem. Biophys. Res. Commun. 226:456-460(1996).
Morris J.C.,et al.Submitted (MAY-1996) to the EMBL/GenBank/DDBJ databases.
Carninci P.,et al.Science 309:1559-1563(2005).
Church D.M.,et al.PLoS Biol. 7:E1000112-E1000112(2009).
Ishii T.,et al.Biochem. Biophys. Res. Commun. 232:33-37(1997).
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 Research Articles on Sqstm1    1. SQSTM1 is required for proper dynein motility and trafficking along microtubules.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-Sqstm1 antibodyPathways associated with anti-Sqstm1 antibody
 Reference Product  PubMed Publications
 Map1lc3b antibody  >53 publications with Sqstm1 and Map1lc3b
 Nbr1 antibody  >42 publications with Sqstm1 and Nbr1
 Keap1 antibody  >36 publications with Sqstm1 and Keap1
 Traf6 antibody  >26 publications with Sqstm1 and Traf6
 Map1lc3a antibody  >25 publications with Sqstm1 and Map1lc3a
 Myd88 antibody  >8 publications with Sqstm1 and Myd88
 Cyld antibody  >4 publications with Sqstm1 and Cyld
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Diseases associated with anti-Sqstm1 antibodyOrgans/Tissues associated with anti-Sqstm1 antibody
 Disease Name  Pubmed Publications
 Osteitis Deformans Antibodies  >103 publications with Sqstm1 and Osteitis Deformans
 Amyotrophic Lateral Sclerosis Antibodies  >59 publications with Sqstm1 and Amyotrophic Lateral Sclerosis
 Liver Diseases Antibodies  >54 publications with Sqstm1 and Liver Diseases
 Inflammation Antibodies  >53 publications with Sqstm1 and Inflammation
 Necrosis Antibodies  >51 publications with Sqstm1 and Necrosis
 Disease Models, Animal Antibodies  >48 publications with Sqstm1 and Disease Models, Animal
 Lung Diseases Antibodies  >31 publications with Sqstm1 and Lung Diseases
 Carcinoma, Hepatocellular Antibodies  >29 publications with Sqstm1 and Carcinoma, Hepatocellular
 Breast Neoplasms Antibodies  >25 publications with Sqstm1 and Breast Neoplasms
 Cardiovascular Diseases Antibodies  >25 publications with Sqstm1 and Cardiovascular Diseases
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >157 publications with Sqstm1 and Brain
 Bone Antibodies  >154 publications with Sqstm1 and Bone
 Liver Antibodies  >84 publications with Sqstm1 and Liver
 Blood Antibodies  >76 publications with Sqstm1 and Blood
 Muscle Antibodies  >75 publications with Sqstm1 and Muscle
 Lung Antibodies  >45 publications with Sqstm1 and Lung
 Heart Antibodies  >35 publications with Sqstm1 and Heart
 Kidney Antibodies  >30 publications with Sqstm1 and Kidney
 Spinal Cord Antibodies  >23 publications with Sqstm1 and Spinal Cord
 Skin Antibodies  >21 publications with Sqstm1 and Skin
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