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anti-Src antibody :: Rabbit Src Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS540118
Unit / Price
0.1 mg Affinity-Purified  /  $390 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Src, Polyclonal Antibody

 Also Known As   

Src Antibody

 Product Synonym Names    ASV; Avian sarcoma virus; c SRC; CDNA FLJ14219 fis clone NT2RP3003800 highly similar to Rattus norvegicus tyrosine protein kinase pp60 c src mRNA; EC 2.7.10.2; Neuronal CSRC tyrosine specific protein kinase; Neuronal SRC; Oncogene SRC; p60 Src; Proto-oncogene tyrosine-protein kinase Src; SRC proto oncogene non receptor tyrosine kinase; SRC1; Tyrosine kinase pp60c src; Tyrosine protein kinase SRC1; v src avian sarcoma (Schmidt Ruppin A2) viral oncogene homolog antibody
 Product Gene Name   

anti-Src antibody

[Similar Products]
 Matching Pairs    Antibody: Src (MBS540118)
Positive Control: Src (MBS543282)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    190090
 3D Structure    ModBase 3D Structure for P12931
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Concentration    0.56-0.60 ug/ul in antibody stabilization buffer (lot specific)
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 Immunogen    Synthetic peptide taken within amino acid region 400-500 on human Src protein.
 Expression    Expressed ubiquitously. Platelets, neurons and osteoclasts express 5-fold to 200-fold higher levels than most other tissues.
 Determinant    C-epitope
 Molecular Function    ATP binding, ephrin receptor binding, heme binding, ion channel binding, enzyme binding, growth factor receptor binding, integrin binding, kinase activity
 Structure    Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily. Contains 1 protein kinase domain. Contains 1 SH2 domain. Contains 1 SH3 domain.
 Subcellular Location    Cell membrane, mitochondrion inner membrane, nucleus, Cytoplasm (Note: Localizes to focal adhesion sites following integrin engagement. Localization to focal adhesion sites requires myristoylation and SH3 domain.)
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 Preparation and Storage    -20 degree C for long term storage
 Other Notes    Small volumes of anti-Src antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-Src antibody

   Proto-oncogene tyrosine-protein kinase Src Antibody C-epitope
Participates in signaling pathways that control a diverse spectrum of biological activities including gene transcription, immune response, cell adhesion, cell cycle progression, apoptosis migration, and transformation.
 Product Categories/Family for anti-Src antibody    Primary Antibodies; Protein Kinases; Tyrosine Kinases; Src Family; Src Antibody
 Applications Tested/Suitable for anti-Src antibody   

Confocal Microscopy (CM), ELISA (EIA), Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB)

 Application Notes for anti-Src antibody    Confocal Microscopy||1:100
Dot Blot: 1:10,000
ELISA: 1:10,000
Immunocytochemistry: 1:100
Immunofluorescence: 1:100
Immunohistochemistry: 1:100
Immunoprecipitation: 1:250
Western Blot: 1:500
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 Western Blot (WB) of anti-Src antibody    anti-Src antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-Src antibody    anti-Src antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-Src antibody    anti-Src antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for Src. It may not necessarily be applicable to this product.
 NCBI GI #    4885609
 NCBI GeneID    6714
 NCBI Accession #    NP_005408.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_005417.4 [Other Products]
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 UniProt Primary Accession #    P12931 [Other Products]
 UniProt Secondary Accession #    Q76P87; Q86VB9; Q9H5A8; E1P5V4 [Other Products]
 UniProt Related Accession #    P12931 [Other Products]
 Molecular Weight    60,589 Da
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 NCBI Official Full Name    proto-oncogene tyrosine-protein kinase Src
 NCBI Official Synonym Full Names    SRC proto-oncogene, non-receptor tyrosine kinase
 NCBI Official Symbol    SRC [Similar Products]
 NCBI Official Synonym Symbols   
ASV; SRC1; THC6; c-SRC; p60-Src
[Similar Products]
 NCBI Protein Information    proto-oncogene tyrosine-protein kinase Src
 UniProt Protein Name    Proto-oncogene tyrosine-protein kinase Src
 UniProt Synonym Protein Names   
Proto-oncogene c-Src; pp60c-src; p60-Src
 Protein Family    Src-like-adapter
 UniProt Gene Name    SRC [Similar Products]
 UniProt Synonym Gene Names    SRC1; p60-Src [Similar Products]
 UniProt Entry Name    SRC_HUMAN
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 NCBI Summary for Src    This gene is highly similar to the v-src gene of Rous sarcoma virus. This proto-oncogene may play a role in the regulation of embryonic development and cell growth. The protein encoded by this gene is a tyrosine-protein kinase whose activity can be inhibited by phosphorylation by c-SRC kinase. Mutations in this gene could be involved in the malignant progression of colon cancer. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
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 UniProt Comments for Src    Src: proto-oncogenic cytoplasmic tyrosine kinase of the SRC family. Highly expressed in certain fully differentiated cells such as neurons, platelets and macrophages. Phosphorylation of an activation loop tyrosine activates the enzyme; phosphorylation of a tyrosine in the C-terminus by Csk inhibits the enzyme. Two alternatively spliced isoforms have been described.

Protein type: Kinase, protein; EC 2.7.10.2; Protein kinase, TK; Oncoprotein; Protein kinase, tyrosine (non-receptor); TK group; Src family

Chromosomal Location of Human Ortholog: 20q12-q13

Cellular Component: actin filament; caveola; cytoplasm; cytosol; extrinsic to internal side of plasma membrane; late endosome; lysosome; mitochondrial inner membrane; mitochondrion; neuron projection; nucleus; perinuclear region of cytoplasm; plasma membrane; postsynaptic density

Molecular Function: ATP binding; enzyme binding; ephrin receptor binding; estrogen receptor binding; heme binding; hormone receptor binding; insulin receptor binding; integrin binding; kinase activity; kinase binding; non-membrane spanning protein tyrosine kinase activity; phosphoprotein binding; protein binding; protein C-terminus binding; protein kinase activity; protein kinase C binding; protein-tyrosine kinase activity; receptor binding; SH2 domain binding; SH3/SH2 adaptor activity

Biological Process: activation of protein kinase B; bone resorption; cell cycle; cell proliferation; cell-cell adhesion; cellular response to insulin stimulus; central nervous system development; ephrin receptor signaling pathway; epidermal growth factor receptor signaling pathway; estrogen receptor signaling pathway; forebrain development; innate immune response; integrin-mediated signaling pathway; leukocyte migration; negative regulation of apoptosis; negative regulation of caspase activity; negative regulation of focal adhesion formation; negative regulation of mitochondrial depolarization; negative regulation of protein homooligomerization; negative regulation of telomerase activity; negative regulation of telomere maintenance via telomerase; negative regulation of transcription, DNA-dependent; nerve growth factor receptor signaling pathway; oogenesis; peptidyl-serine phosphorylation; peptidyl-tyrosine phosphorylation; platelet activation; platelet-derived growth factor receptor signaling pathway; positive regulation of apoptosis; positive regulation of cyclin-dependent protein kinase activity; positive regulation of cytokine secretion; positive regulation of insulin receptor signaling pathway; positive regulation of integrin activation; positive regulation of MAP kinase activity; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of phosphoinositide 3-kinase activity; positive regulation of protein amino acid autophosphorylation; positive regulation of protein kinase B signaling cascade; positive regulation of smooth muscle cell migration; positive regulation of transcription, DNA-dependent; progesterone receptor signaling pathway; protein amino acid autophosphorylation; protein destabilization; regulation of bone resorption; regulation of cell cycle; regulation of cell proliferation; regulation of cell-cell adhesion; regulation of estrogen receptor signaling pathway; regulation of protein binding; regulation of vascular permeability; response to acidity; response to drug; response to electrical stimulus; response to hydrogen peroxide; response to mechanical stimulus; response to mineralocorticoid stimulus; response to nutrient levels; response to virus; signal complex assembly; signal transduction; stimulatory C-type lectin receptor signaling pathway; stress fiber formation; T cell costimulation; transcytosis; transforming growth factor beta receptor signaling pathway; uterus development; vascular endothelial growth factor receptor signaling pathway; viral reproduction
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 Research Articles on Src    1. Thus, Src inhibitors emerge as a new class of drugs able to promote frataxin accumulation, suggesting their possible use as therapeutics in Friedreich's Ataxia
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-Src antibodyPathways associated with anti-Src antibody
 Reference Product  PubMed Publications
 EGFR antibody  >1506 publications with Src and EGFR
 STAT3 antibody  >956 publications with Src and STAT3
 PTK2 antibody  >686 publications with Src and PTK2
 CRK antibody  >674 publications with Src and CRK
 CBL antibody  >547 publications with Src and CBL
 PXN antibody  >185 publications with Src and PXN
 BCAR1 antibody  >175 publications with Src and BCAR1
 KHDRBS1 antibody  >99 publications with Src and KHDRBS1
 PTPN1 antibody  >84 publications with Src and PTPN1
 ESR1 antibody  >17 publications with Src and ESR1
 Products by Pathway  Pathway Diagram
 ADP Signalling Through P2Y Purinoceptor 1 Pathway antibodies  ADP Signalling Through P2Y Purinoceptor 1 Pathway Diagram
 AGE/RAGE Pathway antibodies  AGE/RAGE Pathway Diagram
 ARMS-mediated Activation Pathway antibodies  ARMS-mediated Activation Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Adherens Junction Pathway antibodies  Adherens Junction Pathway Diagram
 Adherens Junction Pathway antibodies  Adherens Junction Pathway Diagram
 AhR Pathway antibodies  AhR Pathway Diagram
 Alpha-synuclein Signaling Pathway antibodies  Alpha-synuclein Signaling Pathway Diagram
 Alpha6-Beta4 Integrin Signaling Pathway antibodies  Alpha6-Beta4 Integrin Signaling Pathway Diagram
 Androgen Receptor Signaling Pathway antibodies  Androgen Receptor Signaling Pathway Diagram
Diseases associated with anti-Src antibodyOrgans/Tissues associated with anti-Src antibody
 Disease Name  Pubmed Publications
 Cell Transformation, Neoplastic Antibodies  >1941 publications with Src and Cell Transformation, Neoplastic
 Breast Neoplasms Antibodies  >1226 publications with Src and Breast Neoplasms
 Inflammation Antibodies  >980 publications with Src and Inflammation
 Disease Models, Animal Antibodies  >898 publications with Src and Disease Models, Animal
 Nervous System Diseases Antibodies  >814 publications with Src and Nervous System Diseases
 Neoplasm Metastasis Antibodies  >762 publications with Src and Neoplasm Metastasis
 Neoplasms, Experimental Antibodies  >750 publications with Src and Neoplasms, Experimental
 Necrosis Antibodies  >666 publications with Src and Necrosis
 Neoplasm Invasiveness Antibodies  >650 publications with Src and Neoplasm Invasiveness
 Lung Neoplasms Antibodies  >508 publications with Src and Lung Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >5471 publications with Src and Blood
 Brain Antibodies  >2243 publications with Src and Brain
 Muscle Antibodies  >1683 publications with Src and Muscle
 Bone Antibodies  >1456 publications with Src and Bone
 Kidney Antibodies  >1230 publications with Src and Kidney
 Lung Antibodies  >1224 publications with Src and Lung
 Nerve Antibodies  >1102 publications with Src and Nerve
 Liver Antibodies  >965 publications with Src and Liver
 Embryonic Tissue Antibodies  >553 publications with Src and Embryonic Tissue
 Prostate Antibodies  >545 publications with Src and Prostate
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