P52823.1
[Other Products]
UniProt Primary Accession #
|
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
Stanniocalcin-1
NCBI Official Synonym Full Names
stanniocalcin 1
NCBI Official Synonym Symbols
NCBI Protein Information
stanniocalcin-1
UniProt Protein Name
Stanniocalcin-1
UniProt Synonym Gene Names
UniProt Entry Name
STC1_HUMAN
NCBI Summary for STC1
This gene encodes a secreted, homodimeric glycoprotein that is expressed in a wide variety of tissues and may have autocrine or paracrine functions. The gene contains a 5' UTR rich in CAG trinucleotide repeats. The encoded protein contains 11 conserved cysteine residues and is phosphorylated by protein kinase C exclusively on its serine residues. The protein may play a role in the regulation of renal and intestinal calcium and phosphate transport, cell metabolism, or cellular calcium/phosphate homeostasis. Overexpression of human stanniocalcin 1 in mice produces high serum phosphate levels, dwarfism, and increased metabolic rate. This gene has altered expression in hepatocellular, ovarian, and breast cancers. [provided by RefSeq, Jul 2008]
UniProt Comments for STC1
STC1: Stimulates renal phosphate reabsorption, and could therefore prevent hypercalcemia. Belongs to the stanniocalcin family.
Protein type: Secreted, signal peptide; Secreted
Chromosomal Location of Human Ortholog: 8p21.2
Cellular Component: extracellular space; cytoplasm; apical plasma membrane; nucleus
Molecular Function: hormone activity
Biological Process: cellular calcium ion homeostasis; negative regulation of calcium ion transport; ossification; response to vitamin D; endothelial cell morphogenesis; decidualization; negative regulation of cell migration; embryo implantation
Research Articles on STC1
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice. It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Products associated with anti-STC1 antibody
Diseases associated with anti-STC1 antibody
Organs/Tissues associated with anti-STC1 antibody
|