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anti-SCD antibody :: Goat Stearoyl-CoA desaturase Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS421254
Immunohistochemistry (IHC)
Unit / Price
0.1 mg  /  $300 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Stearoyl-CoA desaturase (SCD), Polyclonal Antibody

 Also Known As   

Goat anti-Stearoyl-CoA desaturase Antibody

 Product Synonym Names    SCD; SCD1; HGNC: 10571; FADS5; PRO0998; acyl-CoA desaturase; delta-9-desaturase; fatty acid desaturase; predicted protein of HQ0998; stearoyl-CoA desaturase; SCD antibody; SCD1 antibody; HGNC: 10571 antibody; FADS5 antibody; PRO0998 antibody; acyl-CoA desaturase antibody; delta-9-desaturase antibody; fatty acid desaturase antibody; predicted protein of HQ0998 antibody; stearoyl-CoA desaturase antibody; Stearoyl-CoA desaturase; Stearoyl-CoA desaturase
 Product Gene Name   

anti-SCD antibody

[Similar Products]
 Antibody/Peptide Pairs    Stearoyl-CoA desaturase peptide (MBS425292) is used for blocking the activity of Stearoyl-CoA desaturase antibody (MBS421254)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    RIKRTGDGNY KSG
 OMIM    604031
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 Clonality    Polyclonal
 Host    Goat
 Species Reactivity    Tested: Human; Expected from sequence similarity: Human
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 Purity/Purification    Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
 Form/Format    Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
 Concentration    100ug specific antibody in 200ul (lot specific)
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 Immunogen    Peptide with sequence C-RIKRTGDGNYKSG, from the C Terminus of the protein sequence according to NP_005054.3.
 Epitope    C Terminus
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 Preparation and Storage    Aliquot and store at -20 degree C. Minimize freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of anti-SCD antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-SCD antibody   

Peptide ELISA (EIA), Immunohistochemistry (IHC)

 Application Notes for anti-SCD antibody    Peptide ELISA: Antibody detection limit dilution 1: 64000.
Immunohistochemistry: In paraffin embedded Human Liver shows textured cytoplam staining in hepatocytes. Recommended concentration, 5-10ug/ml.
Western Blot: Preliminary experiments gave an approx 30kDa band in Human Adipose, Brain and Liver lysates after 0.3 ug/ml antibody staining. Please note that currently we cannot find an explanation in the literature for the band we observe given the calculated size of 41.5kDa according to NP_005054.3. The 30kDa band was successfully blocked by incubation with the immunizing peptide.
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 Immunohistochemistry (IHC) of anti-SCD antibody    (5ug/ml) staining of paraffin embedded Human Liver. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.
anti-SCD antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for SCD. It may not necessarily be applicable to this product.
 NCBI GI #    53759151
 NCBI GeneID    6319
 NCBI Accession #    NP_005054.3 [Other Products]
 NCBI GenBank Nucleotide #    NM_005063.4 [Other Products]
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 UniProt Secondary Accession #    Q16150; Q53GR9; Q5W037; Q5W038; Q6GSS4; Q96KF6; Q9BS07; Q9Y695; B2R5U0; D3DR68 [Other Products]
 UniProt Related Accession #    O00767 [Other Products]
 Molecular Weight    41,523 Da
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 NCBI Official Full Name    acyl-CoA desaturase
 NCBI Official Synonym Full Names    stearoyl-CoA desaturase (delta-9-desaturase)
 NCBI Official Symbol    SCD [Similar Products]
 NCBI Official Synonym Symbols   
SCD1; FADS5; SCDOS; hSCD1; MSTP008
[Similar Products]
 NCBI Protein Information    acyl-CoA desaturase
 UniProt Protein Name    Acyl-CoA desaturase
 UniProt Synonym Protein Names   
Delta(9)-desaturase; Delta-9 desaturase; Fatty acid desaturase; Stearoyl-CoA desaturase
 Protein Family    Stearoyl-CoA desaturase
 UniProt Gene Name    SCD [Similar Products]
 UniProt Synonym Gene Names    hSCD1 [Similar Products]
 UniProt Entry Name    ACOD_HUMAN
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 NCBI Summary for SCD    This gene encodes an enzyme involved in fatty acid biosynthesis, primarily the synthesis of oleic acid. The protein belongs to the fatty acid desaturase family and is an integral membrane protein located in the endoplasmic reticulum. Transcripts of approximately 3.9 and 5.2 kb, differing only by alternative polyadenlyation signals, have been detected. A gene encoding a similar enzyme is located on chromosome 4 and a pseudogene of this gene is located on chromosome 17. [provided by RefSeq, Sep 2015]
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 UniProt Comments for SCD    SCD: Terminal component of the liver microsomal stearyl-CoA desaturase system, that utilizes O(2) and electrons from reduced cytochrome b5 to catalyze the insertion of a double bond into a spectrum of fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA. Belongs to the fatty acid desaturase family.

Protein type: Endoplasmic reticulum; Membrane protein, integral; EC 1.14.19.1; Membrane protein, multi-pass; Lipid Metabolism - unsaturated fatty acid biosynthesis; Oxidoreductase

Chromosomal Location of Human Ortholog: 10q24.31

Cellular Component: endoplasmic reticulum; endoplasmic reticulum membrane; integral to membrane; membrane

Molecular Function: iron ion binding; oxidoreductase activity; stearoyl-CoA 9-desaturase activity

Biological Process: unsaturated fatty acid biosynthetic process
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 Research Articles on SCD    1. This study illustrates for the first time that, in contrast to hepatic and adipose tissue, estrogen induces SCD-1 expression and activity in breast carcinoma cells. These results support SCD-1 as a therapeutic target in estrogen-sensitive breast cancer.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-SCD antibodyPathways associated with anti-SCD antibody
 Reference Product  PubMed Publications
 SREBF1 antibody  >133 publications with SCD and SREBF1
 FASN antibody  >90 publications with SCD and FASN
 ACACA antibody  >46 publications with SCD and ACACA
 FABP4 antibody  >34 publications with SCD and FABP4
 PPARG antibody  >31 publications with SCD and PPARG
 LEP antibody  >7 publications with SCD and LEP
 UBC antibody  >7 publications with SCD and UBC
 PPARA antibody  >6 publications with SCD and PPARA
 INS antibody  >4 publications with SCD and INS
 Products by Pathway  Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 Activation Of Gene Expression By SREBF (SREBP) Pathway antibodies  Activation Of Gene Expression By SREBF (SREBP) Pathway Diagram
 Adipogenesis Pathway antibodies  Adipogenesis Pathway Diagram
 Biosynthesis Of Unsaturated Fatty Acids Pathway antibodies  Biosynthesis Of Unsaturated Fatty Acids Pathway Diagram
 Biosynthesis Of Unsaturated Fatty Acids Pathway antibodies  Biosynthesis Of Unsaturated Fatty Acids Pathway Diagram
 Fatty Acid Biosynthesis Pathway antibodies  Fatty Acid Biosynthesis Pathway Diagram
 Fatty Acyl-CoA Biosynthesis Pathway antibodies  Fatty Acyl-CoA Biosynthesis Pathway Diagram
 Fatty Acid Metabolism Pathway antibodies  Fatty Acid Metabolism Pathway Diagram
 Fatty Acid Metabolism Pathway antibodies  Fatty Acid Metabolism Pathway Diagram
Diseases associated with anti-SCD antibodyOrgans/Tissues associated with anti-SCD antibody
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >2373 publications with SCD and Cardiovascular Diseases
 Heart Diseases Antibodies  >1863 publications with SCD and Heart Diseases
 Pain Antibodies  >795 publications with SCD and Pain
 Myocardial Infarction Antibodies  >431 publications with SCD and Myocardial Infarction
 Hypertension Antibodies  >394 publications with SCD and Hypertension
 Inflammation Antibodies  >368 publications with SCD and Inflammation
 Fatty Liver Antibodies  >265 publications with SCD and Fatty Liver
 Necrosis Antibodies  >201 publications with SCD and Necrosis
 Kidney Diseases Antibodies  >192 publications with SCD and Kidney Diseases
 Liver Diseases Antibodies  >186 publications with SCD and Liver Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >2522 publications with SCD and Blood
 Heart Antibodies  >1724 publications with SCD and Heart
 Vascular Antibodies  >675 publications with SCD and Vascular
 Bone Antibodies  >517 publications with SCD and Bone
 Liver Antibodies  >491 publications with SCD and Liver
 Brain Antibodies  >466 publications with SCD and Brain
 Muscle Antibodies  >410 publications with SCD and Muscle
 Mouth Antibodies  >377 publications with SCD and Mouth
 Kidney Antibodies  >323 publications with SCD and Kidney
 Lung Antibodies  >311 publications with SCD and Lung
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