NP_001007099.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
56,497 Da
NCBI Official Full Name
non-specific lipid-transfer protein isoform 2
NCBI Official Synonym Full Names
sterol carrier protein 2
NCBI Official Synonym Symbols
NLTP; SCPX; SCP-2; SCP-X; NSL-TP; SCP-CHI [Similar Products]
NCBI Protein Information
non-specific lipid-transfer protein
UniProt Protein Name
Non-specific lipid-transfer protein
UniProt Synonym Protein Names
Propanoyl-CoA C-acyltransferase; SCP-chi; SCPX; Sterol carrier protein 2; SCP-2; Sterol carrier protein X; SCP-X
UniProt Synonym Gene Names
UniProt Entry Name
NLTP_HUMAN
NCBI Summary for SCP2
This gene encodes two proteins: sterol carrier protein X (SCPx) and sterol carrier protein 2 (SCP2), as a result of transcription initiation from 2 independently regulated promoters. The transcript initiated from the proximal promoter encodes the longer SCPx protein, and the transcript initiated from the distal promoter encodes the shorter SCP2 protein, with the 2 proteins sharing a common C-terminus. Evidence suggests that the SCPx protein is a peroxisome-associated thiolase that is involved in the oxidation of branched chain fatty acids, while the SCP2 protein is thought to be an intracellular lipid transfer protein. This gene is highly expressed in organs involved in lipid metabolism, and may play a role in Zellweger syndrome, in which cells are deficient in peroxisomes and have impaired bile acid synthesis. Alternative splicing of this gene produces multiple transcript variants, some encoding different isoforms.[provided by RefSeq, Aug 2010]
UniProt Comments for SCP2
SCP2: Mediates in vitro the transfer of all common phospholipids, cholesterol and gangliosides between membranes. May play a role in regulating steroidogenesis. Defects in SCP2 are a cause of leukoencephalopathy with dystonia and motor neuropathy (LDMN); also known as sterol carrier protein 2 deficiency. LDMN is a syndrome characterized by leukoencephalopathy, dystonic head tremor, spasmodic torticollis and reduced tendon reflexes in lower extremities. Additional features include hyposmia, pathologic saccadic eye movements, a slight hypoacusis, accumulation of branched-chain pristanic acid in plasma, and the presence of abnormal bile alcohol glucuronides in urine. 3 isoforms of the human protein are produced by alternative promoter.
Protein type: Lipid-binding; Lipid Metabolism - primary bile acid biosynthesis; EC 2.3.1.176; Transferase; Mitochondrial
Chromosomal Location of Human Ortholog: 1p32
Cellular Component: cytoplasm; intracellular membrane-bound organelle; membrane; mitochondrion; nucleoplasm; peroxisomal matrix; peroxisome; protein complex
Molecular Function: acyl-CoA binding; cholesterol binding; phosphatidylinositol transporter activity; propanoyl-CoA C-acyltransferase activity; propionyl-CoA C2-trimethyltridecanoyltransferase activity; protein binding; receptor binding; sterol transporter activity
Biological Process: bile acid biosynthetic process; fatty acid beta-oxidation using acyl-CoA oxidase; inositol trisphosphate biosynthetic process; peroxisome organization and biogenesis; phospholipid transport; positive regulation of intracellular cholesterol transport; positive regulation of steroid metabolic process; progesterone biosynthetic process; steroid biosynthetic process; sterol transport
Disease: Leukoencephalopathy With Dystonia And Motor Neuropathy
Research Articles on SCP2
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Pathways associated with anti-SCP2 antibody
Diseases associated with anti-SCP2 antibody
Organs/Tissues associated with anti-SCP2 antibody
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