NP_001025095.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
NCBI Official Full Name
stimulated by retinoic acid gene 6 protein homolog
NCBI Official Synonym Full Names
stimulated by retinoic acid 6
NCBI Official Synonym Symbols
NCBI Protein Information
stimulated by retinoic acid gene 6 protein homolog
UniProt Protein Name
Stimulated by retinoic acid gene 6 protein homolog
UniProt Entry Name
STRA6_RAT
UniProt Comments for Stra6
STRA6: May act as a high-affinity cell-surface receptor for the complex retinol-retinol binding protein (RBP/RBP4). Acts by removing retinol from RBP/RBP4 and transports it across the plasma membrane, where it can be metabolized. This mechanism does not depend on endocytosis. Binds to RBP/RBP4 with high affinity. Increases cellular retinol uptake from the retinol-RBP complex. Defects in STRA6 are the cause of microphthalmia syndromic type 9 (MCOPS9); also called Matthew-Wood syndrome or Spear syndrome. Microphthalmia is a clinically heterogeneous disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues (anophthalmia). In many cases, microphthalmia/anophthalmia occurs in association with syndromes that include non-ocular abnormalities. MCOPS9 is a rare clinical entity including as main characteristics anophthalmia or severe microphthalmia, and pulmonary hypoplasia or aplasia. Mutations in STRA6 may be a cause of isolated colobomatous microphthalmia, a disorder of the eye characterized by an abnormally small ocular globe. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, multi-pass; Membrane protein, integral
Cellular Component: protein complex; integral to membrane; plasma membrane
Molecular Function: receptor activity; vitamin transporter activity
Biological Process: blood vessel development; developmental growth; adrenal gland development; heart development; neuromuscular process; positive regulation of JAK-STAT cascade; ear development; digestive tract morphogenesis; learning; vocal learning; female genitalia development; nose morphogenesis; smooth muscle development; positive regulation of behavior; artery morphogenesis; retinoic acid metabolic process; feeding behavior; cognition; kidney development; alveolus development; embryonic gut development; lung development
Product References and Citations for anti-Stra6 antibody
Strausberg, R.L., et al. Proc. Natl. Acad. Sci. U.S.A. 99(26):16899-16903(2002)
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Products associated with anti-Stra6 antibody
Diseases associated with anti-Stra6 antibody
Organs/Tissues associated with anti-Stra6 antibody
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