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anti-SYN1 antibody :: Rabbit anti-Rat Synapsin (Ser62,67) Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS502116
Testing Data
Unit / Price
0.1 mL  /  $360 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Synapsin (Ser62,67) (SYN1), Polyclonal Antibody

 Also Known As   

Anti-Phospho-Ser62,67 Synapsin I

 Product Gene Name   

anti-SYN1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: X; AC_000187.1 (91192243..91229595, complement). Location: chromosome: X
 3D Structure    ModBase 3D Structure for P17599
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Rat
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 Specificity    Specific for ~78k synapsin I doublet phosphorylated at Ser62,67. Immunolabeling of the synapsin I band is blocked by preadsorption with the phospho-peptide used as antigen but not be the corresponding dephospho-peptide..
 Purity/Purification    Affinity Purified (Prepared from rabbit serum by affinity purification via sequential chromatography on phospho- and dephosphopeptide affinity columns.)
 Form/Format    100 ul in 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 ug per ml BSA and 50% glycerol. Adequate amount of material to conduct 10-mini Western Blots.
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 Antigen    Phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser62,67 of synapsin I.
 Immunogen Information    Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser62/67 conjugated to KLH
 Immunogen Species    Rat
 Reactivity Assumed Based on 100% Sequence Homology    Mouse, and bovine
 Species Reactivity Note    The antibody has been directly tested for reactivity in Western blots with rat tissue. It is anticipated that the antibody will react with mouse, and bovine tissues based on the fact that these species have 100% homology with the amino acid sequence used as antigen.
 Biological Significance    Synapsin I plays a key role in synaptic plasticity in brain (Feng et al., 2002; Nayak et al., 1996). This effect is due in large part to the ability of the synapsins to regulate the availability of synaptic vesicles for release. The role of synapsin in synaptic plasticity and in synaptogensis is regulated by phosphorylation (Jovanovic et al., 2001; Kao et al., 2002). Ser 549 along with Ser 62 and Ser 67 are the sites of Synapsin I that are phosphorylated by MAP kinase (Czernik et al., 1987; Jovanovic et al., 1996).
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 Preparation and Storage    Store at -20 degree C; stable for at least one year
 Other Notes    Small volumes of anti-SYN1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-SYN1 antibody

   Affinity purified rabbit polyclonal antibody
 Applications Tested/Suitable for anti-SYN1 antibody   

Western Blot (WB)

 Application Notes for anti-SYN1 antibody    Quality Control: Western blots performed on each lot.
WB: 1:1000
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 Testing Data of anti-SYN1 antibody    anti-SYN1 antibody Testing Data image
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NCBI/Uniprot data below describe general gene information for SYN1. It may not necessarily be applicable to this product.
 NCBI GI #    27806393
 NCBI GeneID    281510
 NCBI Accession #    NP_776616.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_174191.2 [Other Products]
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 UniProt Primary Accession #    P17599 [Other Products]
 UniProt Related Accession #    P17599 [Other Products]
 Molecular Weight    78
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 NCBI Official Full Name    synapsin-1
 NCBI Official Symbol    SYN1 [Similar Products]
 NCBI Protein Information    synapsin-1
 UniProt Protein Name    Synapsin-1
 UniProt Synonym Protein Names   
Synapsin I
 Protein Family    Synapsin
 UniProt Gene Name    SYN1 [Similar Products]
 UniProt Entry Name    SYN1_BOVIN
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 UniProt Comments for SYN1    Function: Neuronal phosphoprotein that coats synaptic vesicles, binds to the cytoskeleton, and is believed to function in the regulation of neurotransmitter release. The complex formed with NOS1 and CAPON proteins is necessary for specific nitric-oxid functions at a presynaptic level

By similarity.

Subunit structure: Homodimer. Interacts with CAPON. Forms a ternary complex with NOS1. Isoform Ibinteracts with PRNP

By similarity.

Subcellular location: Cell junction › synapse. Golgi apparatus

By similarity.

Domain: The A region binds phospholipids with a preference for negatively charged species

By similarity.

Post-translational modification: Substrate of at least four different protein kinases. Phosphorylation may play a role in the regulation of synapsin-1 in the nerve terminal.Phosphorylation at Ser-9 dissociates synapsins from synaptic vesicles

By similarity.

Sequence similarities: Belongs to the synapsin family.
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Product References and Citations for anti-SYN1 antibody

   • Jovanovic JN, Benfenati, F, Siow YL, Sihra TS, Sanghera JS, Pelech SL, Greengard P,Czernik AJ (1996) Neurotrophins stimulate phosphorylation of Synapsin I by MAP kinase and regulate Synapsin I-actin interactions. Neurobiology 93:3679-3683.
• Czernik AJ, Pang DT, Greengard P (1987) Amino acid sequences surrounding the cAMP-dependent and calcium/calmodulin-dependent phosphorylation sites in rat and bovine synapsin I. Proc Natl Acad Sci (USA) 84:7518-7522.
• Feng J, Chi P, Blanpied TA, Xu YM, Magarinos AM, Ferreira A, Takahashi RH, Kao HT, McEwen BS, Ryan TA, Augustine GJ, Greengard P (2002) Regulation of neurotransmitter release by synapsin III. J Neurosci 22:4372-4380.
• Jovanovic JN, Sihra TS, Nairn AC, Hemmings HC, Jr., Greengard P, Czernik AJ (2001) Opposing changes in phosphorylation of specific sites in synapsin I during Ca2+-dependent glutamate release in isolated nerve terminals. J Neurosci 21:7944-7953.
• Kao HT, Song HJ, Porton B, Ming GL, Hoh J, Abraham M, Czernik AJ, Pieribone VA, Poo MM, Greengard P (2002) A protein kinase A-dependent molecular switch in synapsins regulates neurite outgrowth. Nature Neurosci 5:431-437.
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 Research Articles on SYN1    1. These results raise the possibility that Ser(603) on synapsin I is alternatively phosphorylated by p21-activated kinases, not only by CaMKII, in neuronal cells in response to some stimulants.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Diseases associated with anti-SYN1 antibodyOrgans/Tissues associated with anti-SYN1 antibody
 Disease Name  Pubmed Publications
 Brain Diseases Antibodies  >11 publications with SYN1 and Brain Diseases
 Mental Disorders Antibodies  >11 publications with SYN1 and Mental Disorders
 Central Nervous System Diseases Antibodies  >9 publications with SYN1 and Central Nervous System Diseases
 Neoplasms Antibodies  >6 publications with SYN1 and Neoplasms
 Cognition Disorders Antibodies  >4 publications with SYN1 and Cognition Disorders
 Neurobehavioral Manifestations Antibodies  >4 publications with SYN1 and Neurobehavioral Manifestations
 Seizures Antibodies  >3 publications with SYN1 and Seizures
 Learning Disorders Antibodies  >3 publications with SYN1 and Learning Disorders
 Chromosome Aberrations Antibodies  >3 publications with SYN1 and Chromosome Aberrations
 Necrosis Antibodies  >3 publications with SYN1 and Necrosis
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >29 publications with SYN1 and Brain
 Kidney Antibodies  >1 publications with SYN1 and Kidney
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