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DatasheetFull DatasheetPrinter Friendly DatasheetPrint This DatasheetAdd to Compare ListHave Questions? Ask UsRequest for a Quotation today

anti-SNCA antibody :: Rabbit Synuclein Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS9502552
Unit / Price
0.05 mg  /  $225 +1 FREE 8GB USB
0.1 mg  /  $310 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Synuclein (SNCA), Polyclonal Antibody

★Popular Item★
 Also Known As   

Synuclein (Phospho-Ser129) Antibody

 Product Synonym Names    Alpha-synuclein; Non-A beta component of AD amyloid; Non-A4 component of amyloid precursor; NACP; SNCA; NACP; PARK1
 Product Gene Name   

anti-SNCA antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    L08850 mRNA
 3D Structure    ModBase 3D Structure for P37840
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Specificity    Synuclein (Phospho-Ser129) Antibody detects endogenous levels of Synuclein only when phosphorylated at Ser129.
 Purity/Purification    Purified from rabbit antiserum by affinity-chromatography using phospho peptide. The antibody against non-phospho peptide was removed by chromatography using corresponding non-phospho peptide.
 Form/Format    Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
 Concentration    1 mg/ml (lot specific)
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 Target Modification    Phospho
 Modification Sites    H:S129; M:S129; R:S129
 Immunogen    The antiserum was produced against synthesized peptide derived from human Synuclein around the phosphorylation site of Ser129.
 Immunogen Range    91-140
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 Preparation and Storage    Stable at -20 degree C for at least 1 year.
 Other Notes    Small volumes of anti-SNCA antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-SNCA antibody   

Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA)

 Application Notes for anti-SNCA antibody    WB: 1:500~1:1000
IHC: 1:50~1:100
ELISA: 1:1000
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 Immunohistochemistry (IHC) of anti-SNCA antibody    Immunohistochemistry analysis of paraffin-embedded human brain, using Synuclein (Phospho-Ser129) Antibody. The picture on the right is blocked with the phospho peptide.
anti-SNCA antibody Immunohistochemistry (IHC) (IHC) image
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 Western Blot (WB) of anti-SNCA antibody    Western blot analysis of lysates from mouse brain, using Synuclein (Phospho-Ser129) Antibody. The lane on the right is blocked with the phospho peptide.
anti-SNCA antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for SNCA. It may not necessarily be applicable to this product.
 NCBI GI #    4507109
 NCBI GeneID    6622
 NCBI Accession #    NP_000336.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000345.3 [Other Products]
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 UniProt Primary Accession #    P37840 [Other Products]
 UniProt Secondary Accession #    Q13701; Q4JHI3; Q6IAU6; A8K2A4 [Other Products]
 UniProt Related Accession #    P37840 [Other Products]
 Molecular Weight    14 kDa
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 NCBI Official Full Name    alpha-synuclein isoform NACP140
 NCBI Official Synonym Full Names    synuclein alpha
 NCBI Official Symbol    SNCA [Similar Products]
 NCBI Official Synonym Symbols   
PD1; NACP; PARK1; PARK4
[Similar Products]
 NCBI Protein Information    alpha-synuclein
 UniProt Protein Name    Alpha-synuclein
 UniProt Synonym Protein Names   
Non-A beta component of AD amyloid; Non-A4 component of amyloid precursor; NACP
 Protein Family    Synuclein
 UniProt Gene Name    SNCA [Similar Products]
 UniProt Synonym Gene Names    NACP; PARK1; NACP [Similar Products]
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 NCBI Summary for SNCA    Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Alternatively spliced transcripts encoding different isoforms have been identified for this gene. [provided by RefSeq, Feb 2016]
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 UniProt Comments for SNCA    May be involved in the regulation of dopamine release and transport. Induces fibrillization of microtubule-associated protein tau. Reduces neuronal responsiveness to various apoptotic stimuli, leading to a decreased caspase-3 activation.
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 Research Articles on SNCA    1. elevation of PD-1 expression on CD4(+) T cells is associated with mortality in Cord Blood, and possibly all, SCT recipients.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-SNCA antibodyPathways associated with anti-SNCA antibody
 Reference Product  PubMed Publications
 SNCB antibody  >74 publications with SNCA and SNCB
 MAPT antibody  >64 publications with SNCA and MAPT
 SNCAIP antibody  >31 publications with SNCA and SNCAIP
 PARK2 antibody  >30 publications with SNCA and PARK2
 APP antibody  >16 publications with SNCA and APP
 SLC6A3 antibody  >12 publications with SNCA and SLC6A3
 MAPK1 antibody  >5 publications with SNCA and MAPK1
 TOR1A antibody  >4 publications with SNCA and TOR1A
 BAD antibody  >3 publications with SNCA and BAD
 SQSTM1 antibody  >3 publications with SNCA and SQSTM1
 Products by Pathway  Pathway Diagram
 Alpha-synuclein Signaling Pathway antibodies  Alpha-synuclein Signaling Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Alzheimers Disease Pathway antibodies  Alzheimers Disease Pathway Diagram
 Amyloids Pathway antibodies  Amyloids Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 EGFR1 Signaling Pathway antibodies  EGFR1 Signaling Pathway Diagram
 Parkin-Ubiquitin Proteasomal System Pathway antibodies  Parkin-Ubiquitin Proteasomal System Pathway Diagram
 Parkinson's Disease Pathway antibodies  Parkinson's Disease Pathway Diagram
 Parkinsons Disease Pathway antibodies  Parkinsons Disease Pathway Diagram
Diseases associated with anti-SNCA antibodyOrgans/Tissues associated with anti-SNCA antibody
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >1049 publications with SNCA and Nervous System Diseases
 Brain Diseases Antibodies  >1028 publications with SNCA and Brain Diseases
 Neurodegenerative Diseases Antibodies  >1016 publications with SNCA and Neurodegenerative Diseases
 Movement Disorders Antibodies  >896 publications with SNCA and Movement Disorders
 Parkinsonian Disorders Antibodies  >829 publications with SNCA and Parkinsonian Disorders
 Parkinson Disease Antibodies  >755 publications with SNCA and Parkinson Disease
 Lewy Body Disease Antibodies  >270 publications with SNCA and Lewy Body Disease
 Nerve Degeneration Antibodies  >160 publications with SNCA and Nerve Degeneration
 Disease Models, Animal Antibodies  >127 publications with SNCA and Disease Models, Animal
 Drug Toxicity Antibodies  >71 publications with SNCA and Drug Toxicity
 Organ/Tissue Name  Pubmed Publications
 Nerve Antibodies  >986 publications with SNCA and Nerve
 Brain Antibodies  >718 publications with SNCA and Brain
 Blood Antibodies  >53 publications with SNCA and Blood
 Embryonic Tissue Antibodies  >28 publications with SNCA and Embryonic Tissue
 Kidney Antibodies  >19 publications with SNCA and Kidney
 Heart Antibodies  >9 publications with SNCA and Heart
 Eye Antibodies  >8 publications with SNCA and Eye
 Skin Antibodies  >6 publications with SNCA and Skin
 Bone Antibodies  >6 publications with SNCA and Bone
 Liver Antibodies  >6 publications with SNCA and Liver
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