NP_037483.1
[Other Products]
NCBI GenBank Nucleotide #
|
[Other Products]
UniProt Primary Accession #
|
[Other Products]
UniProt Related Accession #
Molecular Weight
58,328 Da
NCBI Official Full Name
T-box transcription factor TBX21
NCBI Official Synonym Full Names
T-box 21
NCBI Protein Information
T-box transcription factor TBX21
UniProt Protein Name
T-box transcription factor TBX21
UniProt Synonym Protein Names
T-cell-specific T-box transcription factor T-bet; Transcription factor TBLYM
UniProt Synonym Gene Names
NCBI Summary for TBX21
This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene is the human ortholog of mouse Tbx21/Tbet gene. Studies in mouse show that Tbx21 protein is a Th1 cell-specific transcription factor that controls the expression of the hallmark Th1 cytokine, interferon-gamma (IFNG). Expression of the human ortholog also correlates with IFNG expression in Th1 and natural killer cells, suggesting a role for this gene in initiating Th1 lineage development from naive Th precursor cells. [provided by RefSeq, Jul 2008]
UniProt Comments for TBX21
TBX21: Transcription factor that controls the expression of the TH1 cytokine, interferon-gamma. Initiates TH1 lineage development from naive TH precursor cells both by activating TH1 genetic programs and by repressing the opposing TH2 programs. T-cell specific.
Protein type: DNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 17q21.32
Cellular Component: cell soma; nucleus
Molecular Function: DNA binding transcription factor activity; protein binding; sequence-specific DNA binding; transcription regulatory region DNA binding
Biological Process: cellular response to organic substance; lymphocyte migration; multicellular organism development; negative regulation of interleukin-2 production; negative regulation of T-helper 17 cell differentiation; negative regulation of T-helper 17 cell lineage commitment; negative regulation of T-helper 2 cell cytokine production; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; positive regulation of isotype switching to IgG isotypes; positive regulation of transcription, DNA-templated; proteasomal ubiquitin-dependent protein catabolic process; regulation of T cell differentiation; regulation of transcription, DNA-templated; response to virus; T cell differentiation; transcription, DNA-dependent
Disease: Asthma, Nasal Polyps, And Aspirin Intolerance
Research Articles on TBX21
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice. It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Products associated with anti-TBX21 antibody
Pathways associated with anti-TBX21 antibody
Diseases associated with anti-TBX21 antibody
Organs/Tissues associated with anti-TBX21 antibody
|