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anti-TBX3 antibody :: Rabbit anti-Human T-Box Protein 3 (TBX3) Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS2004092 (SPECIAL PROMOTION: Get FREE $5 Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment) anti-TBX3 antibody
Unit / Price
0.1 mg  /  $390 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

T-Box Protein 3 (TBX3), Polyclonal Antibody

 Also Known As   

Biotin-Linked Antibody to T-Box Protein 3 (TBX3)

 Product Gene Name   

anti-TBX3 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 12; NC_000012.11 (115108059..115121969, complement). Location: 12q24.21
 OMIM    181450
 3D Structure    ModBase 3D Structure for O15119
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Specificity    The antibody is a rabbit polyclonal antibody raised against TBX3 conjugated to biotin. It has been selected for its ability to recognize TBX3 in immunohistochemical staining andwestern blotting.
 Purity/Purification    Affinity Chromatography
 Form/Format    Supplied as solution form in PBS, pH7.4, containing 0.02% NaN3,50% glycerol.
 Concentration    200ug/ml (lot specific)
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 Conjugation    Biotin
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 Preparation and Storage    Store at 4 degree C for frequent use. Stored at -20 degree C to -80 degree C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.
 Other Notes    Small volumes of anti-TBX3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-TBX3 antibody    Biotin Antibody
 Applications Tested/Suitable for anti-TBX3 antibody   

Immunohistochemistry (IHC), ELISA (EIA), Western Blot (WB)

 Application Notes for anti-TBX3 antibody    Western blotting: 1:100-400
Immunocytochemistry in formalin fixed cells: 1:100-500
Immunohistochemistry in formalin fixed frozen section: 1:100-500
Immunohistochemistry in paraffin section: 1:50-200
Enzyme-linked Immunosorbent Assay: 1:100-200
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NCBI/Uniprot data below describe general gene information for TBX3. It may not necessarily be applicable to this product.
 NCBI GI #    47419905
 NCBI GeneID    6926
 NCBI Accession #    NP_005987.3 [Other Products]
 NCBI GenBank Nucleotide #    NM_005996.3 [Other Products]
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 UniProt Primary Accession #    O15119 [Other Products]
 UniProt Secondary Accession #    Q8TB20; Q9UKF8 [Other Products]
 UniProt Related Accession #    O15119 [Other Products]
 Molecular Weight    79,389 Da
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 NCBI Official Full Name    T-box transcription factor TBX3 isoform 1
 NCBI Official Synonym Full Names    T-box 3
 NCBI Official Symbol    TBX3 [Similar Products]
 NCBI Official Synonym Symbols   
UMS; XHL; TBX3-ISO
[Similar Products]
 NCBI Protein Information    T-box transcription factor TBX3; T-box protein 3; bladder cancer related protein XHL
 UniProt Protein Name    T-box transcription factor TBX3
 Protein Family    T-box transcription factor
 UniProt Gene Name    TBX3 [Similar Products]
 UniProt Synonym Gene Names    T-box protein 3 [Similar Products]
 UniProt Entry Name    TBX3_HUMAN
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 NCBI Summary for TBX3    This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This protein is a transcriptional repressor and is thought to play a role in the anterior/posterior axis of the tetrapod forelimb. Mutations in this gene cause ulnar-mammary syndrome, affecting limb, apocrine gland, tooth, hair, and genital development. Alternative splicing of this gene results in three transcript variants encoding different isoforms; however, the full length nature of one variant has not been determined. [provided by RefSeq, Jul 2008]
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 UniProt Comments for TBX3    TBX3: Transcriptional repressor involved in developmental processes. Probably plays a role in limb pattern formation. Defects in TBX3 are the cause of ulnar-mammary syndrome (UMS). UMS is characterized by ulnar ray defects, obesity, hypogenitalism, delayed puberty, hypoplasia of nipples and apocrine glands. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: DNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: 12q24.21

Cellular Component: nucleus

Molecular Function: protein binding; sequence-specific DNA binding

Biological Process: embryonic forelimb morphogenesis; positive regulation of transcription, DNA-dependent; limbic system development; negative regulation of epithelial cell differentiation; palate development; negative regulation of transcription from RNA polymerase II promoter; female genitalia development; forelimb morphogenesis; mammary gland development; determination of anterior/posterior axis, embryo; positive regulation of cell proliferation; male genitalia development; heart looping; skeletal development; luteinizing hormone secretion; specification of organ position; blood vessel development; transcription, DNA-dependent; in utero embryonic development; stem cell maintenance; cell aging; positive regulation of cell cycle; regulation of transcription from RNA polymerase II promoter; organ morphogenesis; mesoderm morphogenesis; embryonic digit morphogenesis; follicle-stimulating hormone secretion; negative regulation of myoblast differentiation; negative regulation of transcription, DNA-dependent; negative regulation of apoptosis

Disease: Ulnar-mammary Syndrome
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 Research Articles on TBX3    1. Oncogenic B-RAF(V600E) signaling induces the T-Box3 transcriptional repressor to repress E-cadherin and enhance melanoma cell invasion.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-TBX3 antibodyDiseases associated with anti-TBX3 antibody
 Reference Product  PubMed Publications
 BMP4 antibody  >11 publications with TBX3 and BMP4
 CDKN2A antibody  >7 publications with TBX3 and CDKN2A
 GATA6 antibody  >4 publications with TBX3 and GATA6
 MSX2 antibody  >3 publications with TBX3 and MSX2
 HDAC1 antibody  >2 publications with TBX3 and HDAC1
 SOX4 antibody  >1 publications with TBX3 and SOX4
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >50 publications with TBX3 and Neoplasms
 Ulnar-mammary syndrome Antibodies  >46 publications with TBX3 and Ulnar-mammary syndrome
 Cardiovascular Diseases Antibodies  >21 publications with TBX3 and Cardiovascular Diseases
 Heart Diseases Antibodies  >20 publications with TBX3 and Heart Diseases
 Breast Neoplasms Antibodies  >16 publications with TBX3 and Breast Neoplasms
 Heart Defects, Congenital Antibodies  >12 publications with TBX3 and Heart Defects, Congenital
 Neoplasm Metastasis Antibodies  >7 publications with TBX3 and Neoplasm Metastasis
 Neoplasms, Experimental Antibodies  >6 publications with TBX3 and Neoplasms, Experimental
 Carcinoma, Hepatocellular Antibodies  >5 publications with TBX3 and Carcinoma, Hepatocellular
 Liver Diseases Antibodies  >5 publications with TBX3 and Liver Diseases
Organs/Tissues associated with anti-TBX3 antibody
 Organ/Tissue Name  Pubmed Publications
 Heart Antibodies  >66 publications with TBX3 and Heart
 Embryonic Tissue Antibodies  >45 publications with TBX3 and Embryonic Tissue
 Mammary Gland Antibodies  >26 publications with TBX3 and Mammary Gland
 Brain Antibodies  >16 publications with TBX3 and Brain
 Nerve Antibodies  >14 publications with TBX3 and Nerve
 Liver Antibodies  >13 publications with TBX3 and Liver
 Eye Antibodies  >10 publications with TBX3 and Eye
 Lung Antibodies  >8 publications with TBX3 and Lung
 Skin Antibodies  >8 publications with TBX3 and Skin
 Bladder Antibodies  >4 publications with TBX3 and Bladder
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