AAH39739.1
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UniProt Related Accession #
NCBI Official Full Name
T-box 21
NCBI Official Synonym Full Names
T-box 21
NCBI Protein Information
T-box transcription factor TBX21; T-box protein 21; T-box expressed in T cells; transcription factor TBLYM; T-cell-specific T-box transcription factor T-bet
UniProt Protein Name
T-box transcription factor TBX21
UniProt Synonym Protein Names
T-cell-specific T-box transcription factor T-bet; Transcription factor TBLYM
UniProt Synonym Gene Names
UniProt Entry Name
TBX21_HUMAN
NCBI Summary for TBX21
This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene is the human ortholog of mouse Tbx21/Tbet gene. Studies in mouse show that Tbx21 protein is a Th1 cell-specific transcription factor that controls the expression of the hallmark Th1 cytokine, interferon-gamma (IFNG). Expression of the human ortholog also correlates with IFNG expression in Th1 and natural killer cells, suggesting a role for this gene in initiating Th1 lineage development from naive Th precursor cells. [provided by RefSeq, Jul 2008]
UniProt Comments for TBX21
TBX21: Transcription factor that controls the expression of the TH1 cytokine, interferon-gamma. Initiates TH1 lineage development from naive TH precursor cells both by activating TH1 genetic programs and by repressing the opposing TH2 programs. T-cell specific.
Protein type: DNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 17q21.32
Cellular Component: cell soma; nucleus
Molecular Function: transcription factor activity
Biological Process: positive regulation of isotype switching to IgG isotypes; transcription, DNA-dependent; regulation of transcription, DNA-dependent; multicellular organismal development; response to virus; positive regulation of transcription, DNA-dependent; T cell differentiation
Disease: Asthma, Nasal Polyps, And Aspirin Intolerance
Research Articles on TBX21
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Products associated with anti-TBX21 antibody
Pathways associated with anti-TBX21 antibody
Diseases associated with anti-TBX21 antibody
Organs/Tissues associated with anti-TBX21 antibody
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