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anti-MAL antibody :: Goat T-cell differentiation protein Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS420881 anti-MAL antibody
Unit / Price
0.1 mg  /  $225 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

T-cell differentiation protein (MAL), Polyclonal Antibody

 Also Known As   

Goat anti-T-cell differentiation protein Antibody

 Product Synonym Names    MAL; mal, T-cell differentiation protein; T-cell differentiation protein MAL; T-lymphocyte maturation-associated protein; myelin and lymphocyte protein; MAL antibody; mal; T-cell differentiation protein antibody; T-cell differentiation protein MAL antibody; T-lymphocyte maturation-associated protein antibody; myelin and lymphocyte protein antibody; T-cell differentiation protein; T-cell differentiation protein
 Product Gene Name   

anti-MAL antibody

[Similar Products]
 Antibody/Peptide Pairs    T-cell differentiation protein peptide (MBS425754) is used for blocking the activity of T-cell differentiation protein antibody (MBS420881)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    QDGFTYRHYH EN
 OMIM    188860
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 Clonality    Polyclonal
 Host    Goat
 Species Reactivity    Expected from sequence similarity: Human, Mouse, Rat
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 Purity/Purification    Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
 Form/Format    Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
 Concentration    100ug specific antibody in 200ul (lot specific)
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 Immunogen    Peptide with sequence C-QDGFTYRHYHEN, from the internal region of the protein sequence according to NP_002362.1; NP_071884.1.
 Epitope    Internal region
 Note    This antibody is expected to recognise isoform a (NP_002362.1) and isoform c (NP_071884.1).
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 Preparation and Storage    Aliquot and store at -20 degree C. Minimize freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of anti-MAL antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-MAL antibody   

Peptide ELISA (EIA)

 Application Notes for anti-MAL antibody    Peptide ELISA: Antibody detection limit dilution 1: 4000.
Western Blot: Preliminary experiments gave an approx 35kDa band in Human Thymus and Thyroid Gland lysates after 0.3ug/ml antibody staining. Please note that currently we cannot find an explanation in the literature for the band we observe given the calculated size of 16.7kDa according to NP_002362.1. The 35kDa band was successfully blocked by incubation with the immunizing peptide.
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NCBI/Uniprot data below describe general gene information for MAL. It may not necessarily be applicable to this product.
 NCBI GI #    4505091
 NCBI GeneID    4118
 NCBI Accession #    NP_002362.1 [Other Products]
 NCBI Related Accession #    NP_071884.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_002371.3 [Other Products]
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 UniProt Secondary Accession #    Q6FH77 [Other Products]
 UniProt Related Accession #    P21145 [Other Products]
 Molecular Weight    5,989 Da
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 NCBI Official Full Name    myelin and lymphocyte protein isoform a
 NCBI Official Synonym Full Names    mal, T-cell differentiation protein
 NCBI Official Symbol    MAL [Similar Products]
 NCBI Protein Information    myelin and lymphocyte protein
 UniProt Protein Name    Myelin and lymphocyte protein
 UniProt Synonym Protein Names   
T-lymphocyte maturation-associated protein
 Protein Family    Myelin and lymphocyte protein
 UniProt Gene Name    MAL [Similar Products]
 UniProt Entry Name    MAL_HUMAN
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 NCBI Summary for MAL    The protein encoded by this gene is a highly hydrophobic integral membrane protein belonging to the MAL family of proteolipids. The protein has been localized to the endoplasmic reticulum of T-cells and is a candidate linker protein in T-cell signal transduction. In addition, this proteolipid is localized in compact myelin of cells in the nervous system and has been implicated in myelin biogenesis and/or function. The protein plays a role in the formation, stabilization and maintenance of glycosphingolipid-enriched membrane microdomains. Down-regulation of this gene has been associated with a variety of human epithelial malignancies. Alternative splicing produces four transcript variants which vary from each other by the presence or absence of alternatively spliced exons 2 and 3. [provided by RefSeq, May 2012]
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 UniProt Comments for MAL    MAL: Could be an important component in vesicular trafficking cycling between the Golgi complex and the apical plasma membrane. Could be involved in myelin biogenesis and/or myelin function. Belongs to the MAL family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, multi-pass; Membrane protein, integral

Chromosomal Location of Human Ortholog: 2q11.1

Cellular Component: apical plasma membrane; endoplasmic reticulum; endosome; extrinsic to membrane; integral to plasma membrane; lipid raft

Molecular Function: apoptotic protease activator activity; channel activity; lipid binding; protein binding; structural constituent of myelin sheath

Biological Process: apical protein localization; apoptosis; cell differentiation; central nervous system development; lipid raft polarization; myelination; transmembrane transport
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 Research Articles on MAL    1. Hypermethylation of the selected markers (MAL, PRIMA1, PTGDR and SFRP1) can result in reduced gene expression and may contribute to the formation of colorectal cancer.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-MAL antibodyDiseases associated with anti-MAL antibody
 Reference Product  PubMed Publications
 MYD88 antibody  >179 publications with MAL and MYD88
 SRF antibody  >61 publications with MAL and SRF
 SRC antibody  >14 publications with MAL and SRC
 PTK2 antibody  >2 publications with MAL and PTK2
 HNF1A antibody  >2 publications with MAL and HNF1A
 LYN antibody  >1 publications with MAL and LYN
 USP7 antibody  >1 publications with MAL and USP7
 DIAPH1 antibody  >1 publications with MAL and DIAPH1
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >12811 publications with MAL and Cardiovascular Diseases
 Nervous System Diseases Antibodies  >6182 publications with MAL and Nervous System Diseases
 Lung Diseases Antibodies  >6084 publications with MAL and Lung Diseases
 Hypertension Antibodies  >2118 publications with MAL and Hypertension
 Pain Antibodies  >1766 publications with MAL and Pain
 Liver Diseases Antibodies  >1454 publications with MAL and Liver Diseases
 Seizures Antibodies  >1278 publications with MAL and Seizures
 Lung Neoplasms Antibodies  >1107 publications with MAL and Lung Neoplasms
 Inflammation Antibodies  >1015 publications with MAL and Inflammation
 Poisoning Antibodies  >807 publications with MAL and Poisoning
Organs/Tissues associated with anti-MAL antibody
 Organ/Tissue Name  Pubmed Publications
 Heart Antibodies  >6766 publications with MAL and Heart
 Blood Antibodies  >6513 publications with MAL and Blood
 Vascular Antibodies  >4203 publications with MAL and Vascular
 Lung Antibodies  >3381 publications with MAL and Lung
 Brain Antibodies  >1364 publications with MAL and Brain
 Skin Antibodies  >1112 publications with MAL and Skin
 Kidney Antibodies  >824 publications with MAL and Kidney
 Esophagus Antibodies  >389 publications with MAL and Esophagus
 Lymph Node Antibodies  >254 publications with MAL and Lymph Node
 Eye Antibodies  >246 publications with MAL and Eye
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