NP_000724.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
T-cell surface glycoprotein CD3 epsilon chain
NCBI Official Synonym Full Names
CD3e molecule
NCBI Protein Information
T-cell surface glycoprotein CD3 epsilon chain
UniProt Protein Name
T-cell surface glycoprotein CD3 epsilon chain
UniProt Synonym Protein Names
T-cell surface antigen T3/Leu-4 epsilon chain; CD_antigen: CD3e
UniProt Synonym Gene Names
UniProt Entry Name
CD3E_HUMAN
NCBI Summary for CD3E
The protein encoded by this gene is the CD3-epsilon polypeptide, which together with CD3-gamma, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. Defects in this gene cause immunodeficiency. This gene has also been linked to a susceptibility to type I diabetes in women. [provided by RefSeq, Jul 2008]
UniProt Comments for CD3E
CD3E: a T cell surface glycoprotein that is a component of the T cell antigen receptor. The recruitment of Nck by CD3 epsilon reveals a ligand-induced conformational change essential for T cell receptor signaling and synapse formation. Contains 1 immunoglobulin-like domain and 1 ITAM domain.
Protein type: Membrane protein, integral; Receptor, misc.
Chromosomal Location of Human Ortholog: 11q23
Cellular Component: alpha-beta T cell receptor complex; external side of plasma membrane; immunological synapse; integral to plasma membrane; intercellular junction; intracellular; plasma membrane; T cell receptor complex
Molecular Function: protein binding; protein heterodimerization activity; protein kinase binding; receptor signaling complex scaffold activity; receptor signaling protein activity; SH3 domain binding; T cell receptor binding; transmembrane receptor activity
Biological Process: cell surface receptor linked signal transduction; G-protein coupled receptor protein signaling pathway; negative regulation of smoothened signaling pathway; negative thymic T cell selection; positive regulation of alpha-beta T cell proliferation; positive regulation of calcium-mediated signaling; positive regulation of interferon-gamma production; positive regulation of interleukin-2 biosynthetic process; positive regulation of interleukin-4 production; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of T cell anergy; positive regulation of T cell proliferation; protein complex assembly; regulation of apoptosis; regulation of immune response; response to nutrient; signal complex assembly; T cell activation; T cell costimulation; T cell receptor signaling pathway; transmembrane receptor protein tyrosine kinase signaling pathway
Disease: Immunodeficiency 18
Research Articles on CD3E
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Products associated with anti-CD3E antibody
Pathways associated with anti-CD3E antibody
Diseases associated with anti-CD3E antibody
Organs/Tissues associated with anti-CD3E antibody
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