NP_001257413.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
Calculated MW: 47kDa Molecular Weight: 435
NCBI Official Full Name
brachyury protein isoform 2
NCBI Official Synonym Full Names
T brachyury transcription factor
NCBI Official Synonym Symbols
NCBI Protein Information
brachyury protein
UniProt Protein Name
Brachyury protein
UniProt Synonym Protein Names
Protein T
UniProt Entry Name
BRAC_HUMAN
NCBI Summary for T
The protein encoded by this gene is an embryonic nuclear transcription factor that binds to a specific DNA element, the palindromic T-site. It binds through a region in its N-terminus, called the T-box, and effects transcription of genes required for mesoderm formation and differentiation. The protein is localized to notochord-derived cells. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2012]
UniProt Comments for T
Brachyury: Involved in the transcriptional regulation of genes required for mesoderm formation and differentiation. Binds to a palindromic site (called T site) and activates gene transcription when bound to such a site. Genetic variations in T are associated with susceptibility to neural tube defects (NTD). NTD are common congenital malformations. Spina bifida, which results from malformations in the caudal region of the neural tube, is compatible with life but associated with significant morbidity, including lower limb paralysis. T is involved in susceptibility to the development of chordoma (CHDM). Chordomas are rare, clinically malignant tumors derived from notochordal remnants. They occur along the length of the spinal axis, predominantly in the sphenooccipital, vertebral and sacrococcygeal regions. They are characterized by slow growth, local destruction of bone, extension into adjacent soft tissues and rarely, distant metastatic spread. Susceptibility to development of chordomas is due to a T gene duplication.
Protein type: Cell cycle regulation; Transcription factor; Motility/polarity/chemotaxis; DNA-binding
Chromosomal Location of Human Ortholog: 6q27
Cellular Component: cytoplasm; nuclear chromatin; nucleus
Molecular Function: RNA polymerase II transcription factor activity, enhancer binding; transcription factor activity
Biological Process: BMP signaling pathway; determination of anterior/posterior axis, embryo; embryonic skeletal development; heart morphogenesis; mesoderm development; mesoderm migration; negative regulation of transcription from RNA polymerase II promoter; neural plate morphogenesis; neural tube closure; notochord formation; penetration of zona pellucida; positive regulation of cell proliferation; signal transduction; somitogenesis; transcription, DNA-dependent; vasculogenesis; Wnt receptor signaling pathway through beta-catenin
Disease: Neural Tube Defects; Sacral Agenesis With Vertebral Anomalies
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Pathways associated with anti-T antibody
Diseases associated with anti-T antibody
Organs/Tissues associated with anti-T antibody
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