NP_033335.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
NCBI Official Full Name
brachyury protein
NCBI Official Synonym Full Names
brachyury
NCBI Official Synonym Symbols
Lr; T1; Bra; Low; Tl2; Tl3; cou; me75; D17Mit170 [Similar Products]
NCBI Protein Information
brachyury protein
UniProt Protein Name
Brachyury protein
UniProt Synonym Protein Names
Protein T
UniProt Entry Name
BRAC_MOUSE
UniProt Comments for T
Brachyury: Involved in the transcriptional regulation of genes required for mesoderm formation and differentiation. Binds to a palindromic site (called T site) and activates gene transcription when bound to such a site. Genetic variations in T are associated with susceptibility to neural tube defects (NTD). NTD are common congenital malformations. Spina bifida, which results from malformations in the caudal region of the neural tube, is compatible with life but associated with significant morbidity, including lower limb paralysis. T is involved in susceptibility to the development of chordoma (CHDM). Chordomas are rare, clinically malignant tumors derived from notochordal remnants. They occur along the length of the spinal axis, predominantly in the sphenooccipital, vertebral and sacrococcygeal regions. They are characterized by slow growth, local destruction of bone, extension into adjacent soft tissues and rarely, distant metastatic spread. Susceptibility to development of chordomas is due to a T gene duplication.
Protein type: Cell cycle regulation; DNA-binding; Motility/polarity/chemotaxis; Transcription factor
Cellular Component: cytoplasm; chromatin; nucleus
Molecular Function: protein binding; DNA binding; sequence-specific DNA binding; transcription factor activity
Biological Process: transcription from RNA polymerase II promoter; somitogenesis; anatomical structure morphogenesis; transcription, DNA-dependent; neural plate morphogenesis; embryonic skeletal development; multicellular organismal development; mesoderm migration; notochord formation; reproductive process; Wnt receptor signaling pathway through beta-catenin; negative regulation of transcription from RNA polymerase II promoter; notochord development; cardiac muscle cell differentiation; BMP signaling pathway; anterior/posterior pattern formation; regulation of transcription from RNA polymerase II promoter; regulation of transcription, DNA-dependent; neural tube closure; positive regulation of cell proliferation; penetration of zona pellucida; positive regulation of transcription from RNA polymerase II promoter; mesoderm development; vasculogenesis
Disease: Neural Tube Defects
Product References and Citations for anti-T antibody
Herrmann B.G.,et al.Nature 343:617-622(1990). Kispert A.,et al.EMBO J. 12:3211-3220(1993). Kispert A.,et al.EMBO J. 14:4763-4772(1995).
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Pathways associated with anti-T antibody
Diseases associated with anti-T antibody
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