Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
1.855.MyBioSource
Fax 1.858.633.0166    Email sales@mybiosource.com 
tel/fax
menu1 Home Products Ordering Company Help menu7
bottom
   MyBioSource rightarrow Antibody rightarrow TACE rightarrow Polyclonal TACE  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Menu separator
separator
ELISA Kit ELISA Kit
CLIA Kit CLIA Kit
PCR Kit PCR Kit
Monoclonal Antibody Monoclonal Antibody
Polyclonal Antibody Polyclonal Antibody
Secondary Antibody Secondary Antibody
Antigen Antigen
Biochemical Biochemical
cDNA Clone cDNA Clone
siRNA siRNA
Peptide Peptide
Recombinant/Purified Protein Rec./Purified Protein

Custom ELISA Kit Custom ELISA Kit
Custom Protein Custom Protein
Custom Antibody Custom Antibody
Antibody Matched Pairs Antibody Matched Pairs
Antibody & Corresponding Blocking Peptide Pairs Antibody Peptide Pairs
Phospho-Specific Antibodies Phospho Antibodies
Products by Disease Products by Disease
Products by Pathway Products by Pathway
Products by Tissue Products by Tissue

arrow Advanced Search
arrow Submit Technical Q&A
arrow International Distributors
arrow Contact Us
separator
Our Best Sellers moreseparator
separator
 • Apo Transferrin (bApo) Native Protein
 • Cyclin-dependent kinase B1-2 (CDKB1-2) Recombinant Protein
 • GNb1 ELISA Kit
 • RAB3C, member RAS oncogene family ELISA Kit
 • I-309 (I 309) Recombinant Protein
 • CD40 ligand protein (CD40LG) Recombinant Protein
 • alpha 2 Antiplasmin (SERPINF2) Native Protein
 • STAT3 Antibody
 • VAP-1 ELISA Kit
 • ADAMTSL2 cDNA Clone
 • Galactose-1-phosphate uridylyltransferase (Galt) Recombinant Protein
 • Hemoglobin epsilon (HBE1) Antibody
 • Rad51C Antibody
 • EPSTEIN-BARR VIRUS LMP2A Antibody
 downarrow more ...
separator
separator
DatasheetFull DatasheetPrinter Friendly DatasheetPrint This DatasheetAdd to Compare ListHave Questions? Ask UsRequest for a Quotation today

anti-TACE antibody :: Rabbit TACE Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS9402384
Unit / Price
0.1 mL  /  $320 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

TACE, Polyclonal Antibody

★Popular Item★
 Also Known As   

TACE Antibody

 Product Synonym Names    adam17
 Product Gene Name   

anti-TACE antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
Table BarTOPTable Bar
 OMIM    603639
Section Bar
 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
Section Bar
 Purity/Purification    Affinity chromatography purified via peptide column
 Form/Format    Supplied in PBS containing 0.02% sodium azide.
Section Bar
 Immunogen Type    Peptide
 Immunogen Description    Raised against a peptide corresponding to amino acids near the carboxy terminus of human TACE. This sequence differs from those of mouse and rat TACE by one amino acid.
 Target Name    TACE
Section Bar
 Preparation and Storage    Can be stored at -20 degree C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
 Other Notes    Small volumes of anti-TACE antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Table BarTOPTable Bar
 

Related Product Information for anti-TACE antibody

   Tumor-necrosis factor-alpha is a proinflammatory cytokine and contributes to a variety of inflammatory disease responses and programmed cell death. TNF-a is synthesized as a 26K type II membrane-bound precursor that is cleaved by a convertase to generate secreted 17K mature TNF-a. TNF-a converting enzyme (TACE) protein was recently purified and the human and mouse TACE cDNAs were cloned by several groups separately. TACE is a membrane-bound metalloprotease-disintegrin in the family of mammalian ADAM (for a disintegrin and metalloprotease). TACE also processes other cell surface proteins, including TNF receptor, TGFalpha, the L-selectin adhesion molecule, and alpha-cleavage of amyloid protein precursor (APP). TACE mRNA is expressed in a variety of human and murine tissues. TACE was selected as one of the few targets in cytokine activation by the Eighth International Conference of the Inflammation Research Association.
 Product Categories/Family for anti-TACE antibody    Total protein Ab
 Applications Tested/Suitable for anti-TACE antibody   

ELISA (EIA), Western Blot (WB), Immunocytochemistry (ICC), Immunofluorescence (IF), Flow Cytometry (FC/FACS)

Section Bar
 Western Blot (WB) of anti-TACE antibody    Western blot analysis of TACE in HeLa and Jurkat whole cell lysate in the absence or presence of blocking peptide with TACE antibody at 1:500 dilution.
anti-TACE antibody Western Blot (WB) (WB) image
Section Bar
 Immunocytochemistry (ICC) of anti-TACE antibody    Immunocytochemistry of TACE in HeLa cells with TACE antibody at 10 ug/mL.
anti-TACE antibody Immunocytochemistry (ICC) (ICC) image
Table BarTOPTable Bar
NCBI/Uniprot data below describe general gene information for TACE. It may not necessarily be applicable to this product.
 NCBI GI #    73747889
 NCBI GeneID    6868
 NCBI Accession #    NP_003174 [Other Products]
 NCBI GenBank Nucleotide #    NM_003183.4 [Other Products]
Section Bar
 UniProt Secondary Accession #    O60226 [Other Products]
 UniProt Related Accession #    P78536 [Other Products]
 Molecular Weight    78,543 Da
Table BarTOPTable Bar
 NCBI Official Full Name    disintegrin and metalloproteinase domain-containing protein 17 preproprotein
 NCBI Official Synonym Full Names    ADAM metallopeptidase domain 17
 NCBI Official Symbol    ADAM17 [Similar Products]
 NCBI Official Synonym Symbols   
CSVP; TACE; NISBD; ADAM18; CD156B; NISBD1
[Similar Products]
 NCBI Protein Information    disintegrin and metalloproteinase domain-containing protein 17
 UniProt Protein Name    Disintegrin and metalloproteinase domain-containing protein 17
 UniProt Synonym Protein Names   
Snake venom-like protease; TNF-alpha convertase; TNF-alpha-converting enzyme; CD_antigen: CD156b
 Protein Family    ADAM 17-like protease
 UniProt Gene Name    ADAM17 [Similar Products]
 UniProt Synonym Gene Names    CSVP; TACE; ADAM 17 [Similar Products]
 UniProt Entry Name    ADA17_HUMAN
Section Bar
 NCBI Summary for TACE    This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene functions as a tumor necrosis factor-alpha converting enzyme; binds mitotic arrest deficient 2 protein; and also plays a prominent role in the activation of the Notch signaling pathway. [provided by RefSeq, Jul 2008]
Section Bar
 UniProt Comments for TACE    TACE: a type I membrane protein with disintegrin and metalloprotease activity. An ubiquitously expressed ectoenzyme of peptidase family M12B. Must be membrane anchored to cleave the different substrates. The cytoplasmic domain is not required for the this activity. Possesses a narrow endopeptidase specificity. Cleaves Pro-Leu-Ala-Gln-Ala-|-Val-Arg-Ser-Ser-Ser in the membrane-bound, 26-kDa form of tumor necrosis factor alpha (TNF-alpha) to its mature soluble form. Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, and the amyloid precursor protein. Also involved in the activation of Notch pathway. Binds 1 zinc ion per subunit. Two splice variant isoforms have been described.

Protein type: EC 3.4.24.86; Protease; Motility/polarity/chemotaxis; Membrane protein, integral

Chromosomal Location of Human Ortholog: 2p25

Cellular Component: cell surface; focal adhesion; membrane; integral to plasma membrane; apical plasma membrane; cytoplasm; plasma membrane; intercellular junction; lipid raft; actin cytoskeleton

Molecular Function: integrin binding; protein binding; interleukin-6 receptor binding; zinc ion binding; metallopeptidase activity; metalloendopeptidase activity; Notch binding; SH3 domain binding; PDZ domain binding

Biological Process: extracellular matrix organization and biogenesis; nerve growth factor receptor signaling pathway; T cell differentiation in the thymus; neutrophil mediated immunity; cell motility involved in cell locomotion; positive regulation of leukocyte chemotaxis; response to lipopolysaccharide; proteolysis; G1/S-specific positive regulation of cyclin-dependent protein kinase activity; extracellular matrix disassembly; positive regulation of epidermal growth factor receptor activity; positive regulation of cell proliferation; negative regulation of interleukin-8 production; germinal center formation; cell adhesion; spleen development; epidermal growth factor receptor signaling pathway; response to drug; Notch signaling pathway; membrane protein intracellular domain proteolysis; response to high density lipoprotein stimulus; membrane protein ectodomain proteolysis; positive regulation of transforming growth factor beta receptor signaling pathway; Notch receptor processing; positive regulation of cell motility; positive regulation of cell growth; positive regulation of chemokine production; collagen catabolic process; regulation of mast cell apoptosis; PMA-inducible membrane protein ectodomain proteolysis; B cell differentiation; response to hypoxia; cell adhesion mediated by integrin; positive regulation of protein amino acid phosphorylation; negative regulation of transforming growth factor beta receptor signaling pathway; wound healing, spreading of epidermal cells; positive regulation of cell migration

Disease: Inflammatory Skin And Bowel Disease, Neonatal, 1
Table BarTOPTable Bar
 Research Articles on TACE    1. Human NOTCH2 but not mouse Notch2 is resistant to negative regulatory region perturbation and ligand-independent activation by Adam17.
Table BarTOPTable Bar
 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Table BarTOPTable Bar
Products associated with anti-TACE antibodyPathways associated with anti-TACE antibody
 Reference Product  PubMed Publications
 EGFR antibody  >153 publications with TACE and EGFR
 TIMP3 antibody  >23 publications with TACE and TIMP3
 NOTCH1 antibody  >15 publications with TACE and NOTCH1
 ERBB2 antibody  >7 publications with TACE and ERBB2
 ERBB4 antibody  >2 publications with TACE and ERBB4
 PSEN2 antibody  >1 publications with TACE and PSEN2
 NCSTN antibody  >1 publications with TACE and NCSTN
 NOTCH3 antibody  >1 publications with TACE and NOTCH3
 Products by Pathway  Pathway Diagram
 Activated NOTCH1 Transmits Signal To The Nucleus Pathway antibodies  Activated NOTCH1 Transmits Signal To The Nucleus Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Alzheimers Disease Pathway antibodies  Alzheimers Disease Pathway Diagram
 BDNF Signaling Pathway antibodies  BDNF Signaling Pathway Diagram
 Collagen Degradation Pathway antibodies  Collagen Degradation Pathway Diagram
 Constitutive Signaling By NOTCH1 HD Domain Mutants Pathway antibodies  Constitutive Signaling By NOTCH1 HD Domain Mutants Pathway Diagram
 Constitutive Signaling By NOTCH1 HD+PEST Domain Mutants Pathway antibodies  Constitutive Signaling By NOTCH1 HD+PEST Domain Mutants Pathway Diagram
 Constitutive Signaling By NOTCH1 PEST Domain Mutants Pathway antibodies  Constitutive Signaling By NOTCH1 PEST Domain Mutants Pathway Diagram
 Constitutive Signaling By NOTCH1 T(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Pathway antibodies  Constitutive Signaling By NOTCH1 T(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Pathway Diagram
Diseases associated with anti-TACE antibodyOrgans/Tissues associated with anti-TACE antibody
 Disease Name  Pubmed Publications
 Necrosis Antibodies  >557 publications with TACE and Necrosis
 Inflammation Antibodies  >133 publications with TACE and Inflammation
 Disease Models, Animal Antibodies  >31 publications with TACE and Disease Models, Animal
 Breast Neoplasms Antibodies  >28 publications with TACE and Breast Neoplasms
 Liver Diseases Antibodies  >26 publications with TACE and Liver Diseases
 Kidney Diseases Antibodies  >24 publications with TACE and Kidney Diseases
 Atherosclerosis Antibodies  >23 publications with TACE and Atherosclerosis
 Neoplasm Invasiveness Antibodies  >17 publications with TACE and Neoplasm Invasiveness
 Carcinoma, Hepatocellular Antibodies  >16 publications with TACE and Carcinoma, Hepatocellular
 Neoplasm Metastasis Antibodies  >16 publications with TACE and Neoplasm Metastasis
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >87 publications with TACE and Brain
 Kidney Antibodies  >52 publications with TACE and Kidney
 Lung Antibodies  >48 publications with TACE and Lung
 Liver Antibodies  >42 publications with TACE and Liver
 Muscle Antibodies  >41 publications with TACE and Muscle
 Embryonic Tissue Antibodies  >33 publications with TACE and Embryonic Tissue
 Ovary Antibodies  >19 publications with TACE and Ovary
 Prostate Antibodies  >13 publications with TACE and Prostate
 Bone Marrow Antibodies  >11 publications with TACE and Bone Marrow
 Eye Antibodies  >11 publications with TACE and Eye
Table BarTOPTable Bar
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions