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Add To Compare List anti-TACR1 antibody :: Rabbit TACR1 Polyclonal Antibody Catalog # MBS9608042 Unit / Price 0.1 mL / $270 +1 FREE 8GB USB 0.2 mL / $315 +1 FREE 8GB USB 5x0.2 mL / $1,245 +1 FREE 8GB USB Previous Next Product Name Product Info Accession #s Product Desc Diseases/Tissues/Pathways Applications References Product Name TACR1, Polyclonal Antibody Popular Item Full Product Name TACR1 Antibody Product Synonym Names Neurokinin 1; NK 1 receptor; NK 1R; NK-1 receptor; NK-1R; NK1 receptor; NK1R; NK1R_HUMAN; NKIR; SPR; Substance P receptor; Substance-P receptor; TAC 1R; TAC1R; Tachykinin 1 receptor (substance P receptor neurokinin 1 receptor); Tachykinin receptor 1 (substance P receptor neurokinin 1 receptor); Tachykinin receptor 1; TACR1 Product Gene Name anti-TACR1 antibody[Similar Products] Antibody/Peptide Pairs TACR1 peptide (MBS9626754) is used for blocking the activity of TACR1 antibody (MBS9608042) Research Use Only For Research Use Only. Not for use in diagnostic procedures. TOP 3D Structure ModBase 3D Structure for P25103 Clonality Polyclonal Isotype IgG Host Rabbit Species Reactivity Human, Mouse, Rat Specificity TACR1 antibody detects endogenous levels of total TACR1 Purity/Purification The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin. Form/Format LiquidPhosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Concentration 1mg/ml (lot specific) Immunogen A synthesized peptide derived from human TACR1 Subcellular Location Cell Membrane Conjugation Unconjugated Preparation and Storage Store at -20 degree C. Stable for 12 months from date of receipt. ISO Certification Manufactured in an ISO 9001:2015 Certified Laboratory. Supply Chain Verification Manufactured in a lab with traceable raw materials manufactured on site. Coordinated product portfolio of antibodies, pairs, conjugates, recombinant proteins, and immunoassay materials available, please inquire. Other Notes Small volumes of anti-TACR1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply. TOP Related Product Information for anti-TACR1 antibody Description: This gene belongs to a gene family of tachykinin receptors. These tachykinin receptors are characterized by interactions with G proteins and contain seven hydrophobic transmembrane regions. This gene encodes the receptor for the tachykinin substance P, also referred to as neurokinin 1. The encoded protein is also involved in the mediation of phosphatidylinositol metabolism of substance P.Function: This is a receptor for the tachykinin neuropeptide substance P. It is probably associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: substance P > substance K > neuromedin-K.Subunit Structure: Interacts with ARRB1.Similarity: Belongs to the G-protein coupled receptor 1 family. Applications Tested/Suitable for anti-TACR1 antibody Western Blot (WB), Immunohistochemisty (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC), ELISA (EIA) Application Notes for anti-TACR1 antibody WB: 1:500-1:2000IHC: 1:50-1:200IF/ICC: 1:100-1:500 Western Blot (WB) of anti-TACR1 antibody Western blot analysis of MCF7 cell lysate, using TACR1 Antibody. The lane on the left is treated with the antigen-specific peptide. Immunohistochemistry (IHC) of anti-TACR1 antibody MBS9608042 at 1/100 staining Human liver cancer tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22 degree C. An HRP conjugated goat anti-rabbit antibody was used as the secondary. Immunofluorescence (IF) of anti-TACR1 antibody MBS9608042 staining Hela by IF/ICC. The sample were fixed with PFA and permeabilized in 0.1% Triton X-100, then blocked in 10% serum for 45 minutes at 25 degree C. The primary antibody was diluted at 1/200 and incubated with the sample for 1 hour at 37 degree C. An Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) Ab, diluted at 1/600, was used as the secondary antibody. TOP NCBI/Uniprot data below describe general gene information for TACR1. It may not necessarily be applicable to this product. NCBI GI # 4507343 NCBI GeneID 6869 NCBI Accession # NP_001049.1 [Other Products] NCBI GenBank Nucleotide # NM_001058.3 [Other Products] UniProt Primary Accession # P25103 [Other Products] UniProt Secondary Accession # A8K150[Other Products] UniProt Related Accession # P25103[Other Products] Molecular Weight Observed: 46 kDaPredicted: 47 kDa TOP NCBI Official Full Name substance-P receptor isoform long NCBI Official Synonym Full Names tachykinin receptor 1 NCBI Official Symbol TACR1 [Similar Products] NCBI Official Synonym Symbols SPR; NK1R; NKIR; TAC1R [Similar Products] NCBI Protein Information substance-P receptor UniProt Protein Name Substance-P receptor UniProt Synonym Protein Names NK-1 receptor; NK-1R; Tachykinin receptor 1 Protein Family Substance-P receptor UniProt Gene Name TACR1 [Similar Products] UniProt Synonym Gene Names NK1R; TAC1R; SPR; NK-1R [Similar Products] TOP NCBI Summary for TACR1 This gene belongs to a gene family of tachykinin receptors. These tachykinin receptors are characterized by interactions with G proteins and contain seven hydrophobic transmembrane regions. This gene encodes the receptor for the tachykinin substance P, also referred to as neurokinin 1. The encoded protein is also involved in the mediation of phosphatidylinositol metabolism of substance P. [provided by RefSeq, Sep 2008] TOP UniProt Comments for TACR1 This is a receptor for the tachykinin neuropeptide substance P. It is probably associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: substance P > substance K > neuromedin-K. Research Articles on TACR1 1. Study revealed extensive distribution of SP and NK1R in nuclei intimately related to cardiorespiratory function and autonomic control, with significant co-distribution and co-localization with 5-HT in the medullary network in the normal human infant during development. A trend for NK1R binding to decrease with age was observed with significantly higher binding in premature and male infants. TOP Precautions All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines. Disclaimer While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. 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TOP Products associated with anti-TACR1 antibody Reference Product PubMed Publications TAC1 antibody >22 publications with TACR1 and TAC1 TAC3 antibody >3 publications with TACR1 and TAC3 GRK5 antibody >2 publications with TACR1 and GRK5 Pathways associated with anti-TACR1 antibody Products by Pathway Pathway Diagram Calcium Signaling Pathway antibodies Calcium Signaling Pathway Diagram Calcium Signaling Pathway antibodies Calcium Signaling Pathway Diagram Class A/1 (Rhodopsin-like Receptors) Pathway antibodies Class A/1 (Rhodopsin-like Receptors) Pathway Diagram G Alpha (q) Signalling Events Pathway antibodies G Alpha (q) Signalling Events Pathway Diagram GPCR Downstream Signaling Pathway antibodies GPCR Downstream Signaling Pathway Diagram GPCR Ligand Binding Pathway antibodies GPCR Ligand Binding Pathway Diagram Gastrin-CREB Signalling Pathway Via PKC And MAPK antibodies Gastrin-CREB Signalling Pathway Via PKC And MAPK Diagram Measles Pathway antibodies Measles Pathway Diagram Measles Pathway antibodies Measles Pathway Diagram Neuroactive Ligand-receptor Interaction Pathway antibodies Neuroactive Ligand-receptor Interaction Pathway Diagram Diseases associated with anti-TACR1 antibody Disease Name Pubmed Publications Pain Antibodies >581 publications with TACR1 and Pain Inflammation Antibodies >523 publications with TACR1 and Inflammation Vomiting Antibodies >232 publications with TACR1 and Vomiting Neoplasms Antibodies >192 publications with TACR1 and Neoplasms Neurogenic Inflammation Antibodies >171 publications with TACR1 and Neurogenic Inflammation Hyperalgesia Antibodies >171 publications with TACR1 and Hyperalgesia Brain Diseases Antibodies >123 publications with TACR1 and Brain Diseases Edema Antibodies >105 publications with TACR1 and Edema Lung Diseases Antibodies >92 publications with TACR1 and Lung Diseases Necrosis Antibodies >76 publications with TACR1 and Necrosis Organs/Tissues associated with anti-TACR1 antibody Organ/Tissue Name Pubmed Publications Brain Antibodies >1184 publications with TACR1 and Brain Trachea Antibodies >129 publications with TACR1 and Trachea Pancreas Antibodies >60 publications with TACR1 and Pancreas Eye Antibodies >56 publications with TACR1 and Eye Spleen Antibodies >25 publications with TACR1 and Spleen Connective Tissue Antibodies >25 publications with TACR1 and Connective Tissue Uterus Antibodies >22 publications with TACR1 and Uterus Embryonic Tissue Antibodies >19 publications with TACR1 and Embryonic Tissue Adipose Tissue Antibodies >7 publications with TACR1 and Adipose Tissue TOP © 2006-24 MyBioSource.com. 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