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anti-TACR2 antibody :: Rabbit TACR2 / Nk2 / NK2R Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS240078
Immunohistochemistry (IHC)
Unit / Price
0.05 mg  /  $530 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

TACR2 / Nk2 / NK2R, Polyclonal Antibody

★Popular Item★
 Also Known As   

Rabbit Polyclonal to Human TACR2 / Nk2 / NK2R

 Product Synonym Names    Anti-TACR2 / Nk2 / NK2R Antibody (C-Terminus) IHC-plus; TACR2; Neurokinin 2 receptor; NK-2 receptor; Neurokinin A receptor; NK2; NK2R; Tachykinin receptor 2; Substance-K receptor; NK-2R; SK receptor; SKR; TAC2R; NKNAR; Substance K receptor; Human TACR2; Nk2; NK2R
 Product Gene Name   

anti-TACR2 antibody

[Similar Products]
 Product Synonym Gene Name    Nk2; NK2R [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    162321
 3D Structure    ModBase 3D Structure for P21452
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human, Pig
Predicted Reactivity: Rat, Bovine, Dog, Guinea pig, Hamster, Horse, Rabbit
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 Specificity    Human Neurokinin A Receptor. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except TACR1 (47%).
 Purity/Purification    Immunoaffinity Purified
 Form/Format    PBS, less than 0.1% sodium azide.
 Concentration    1 mg/ml (lot specific)
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 Target    TACR2/NK2R
 Target Species    Human
 Immunogen Species    TACR2/NK2R antibody was raised against Human
 Immunogen Description    Synthetic 19 amino acid peptide from C-terminus of human Neurokinin A Receptor. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Pig (100%); Rat, Bovine, Dog, Hamster, Elephant, Panda, Horse, Rabbit, Guinea pig (95%).
 Immunogen Type    Synthetic peptide
 Immunogen    TACR2 / Nk2 / NK2R antibody was raised against synthetic 19 amino acid peptide from C-terminus of human Neurokinin A Receptor. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Pig (100%); Rat, Bovine, Dog, Hamster, Elephant, Panda, Horse, Rabbit, Guinea pig (95%); Monkey, Marmoset, Mouse, Bat (89%).
 Antigen Modification    C-Terminus
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 Preparation and Storage    Upon arrival: Aliquot and store undiluted at -20 degreeC below for up to 1 yr. Can be stored undiluted at 4 degree C for up to 1 month. Avoid freeze thaw cycles.
 Other Notes    Small volumes of anti-TACR2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-TACR2 antibody

   NK2R is a Tachykinin Receptor activated by the neuropeptide substance K, also referred to as neurokinin A. It mediates smooth muscle contraction in central airway and may contribute to the development of asthma.

Immunohistochemistry: MBS240078 was validated for use in immunohistochemistry - on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen. The stained slides were evaluated by a pathologist to confirm staining specificity. The optimal working concentration for MBS240078 was determined to be 40 ug/ml.

Summary: This is a receptor for the tachykinin neuropeptide substance K (neurokinin A). It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: substance K > neuromedin-K > substance P.
 Product Categories/Family for anti-TACR2 antibody    Family: GPCR
Subfamily: Tachykinin
 Applications Tested/Suitable for anti-TACR2 antibody   

Immunohistochemistry (IHC - Paraffin), ELISA (EIA)

 Application Notes for anti-TACR2 antibody    ELISA, IHC-P (40 ug/ml)
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti...
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 Immunohistochemistry (IHC) of anti-TACR2 antibody    Anti-Neurokinin A Receptor antibody IHC of human colon, smooth muscle. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
anti-TACR2 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for TACR2. It may not necessarily be applicable to this product.
 NCBI GI #    157426873
 NCBI GeneID    6865
 NCBI Accession #    NP_001048.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_001057.2 [Other Products]
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 UniProt Primary Accession #    P21452 [Other Products]
 UniProt Secondary Accession #    Q4QRI5; Q8NGQ8; Q9UDE6; Q9UDE7; A8K7I1 [Other Products]
 UniProt Related Accession #    P21452 [Other Products]
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 NCBI Official Full Name    substance-K receptor
 NCBI Official Synonym Full Names    tachykinin receptor 2
 NCBI Official Symbol    TACR2 [Similar Products]
 NCBI Official Synonym Symbols   
SKR; NK2R; NKNAR; TAC2R
[Similar Products]
 NCBI Protein Information    substance-K receptor; NK-2R; NK-2 receptor; substance K receptor; neurokinin 2 receptor; neurokinin A receptor; seven transmembrane helix receptor
 UniProt Protein Name    Substance-K receptor
 UniProt Synonym Protein Names   
NK-2 receptor; NK-2R; Neurokinin A receptor; Tachykinin receptor 2
 Protein Family    Substance-K receptor
 UniProt Gene Name    TACR2 [Similar Products]
 UniProt Synonym Gene Names    NK2R; NKNAR; TAC2R; SKR; NK-2R [Similar Products]
 UniProt Entry Name    NK2R_HUMAN
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 NCBI Summary for TACR2    This gene belongs to a family of genes that function as receptors for tachykinins. Receptor affinities are specified by variations in the 5'-end of the sequence. The receptors belonging to this family are characterized by interactions with G proteins and 7 hydrophobic transmembrane regions. This gene encodes the receptor for the tachykinin neuropeptide substance K, also referred to as neurokinin A. [provided by RefSeq, Jul 2008]
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 UniProt Comments for TACR2    TACR2: This is a receptor for the tachykinin neuropeptide substance K (neurokinin A). It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: substance K > neuromedin-K > substance P. Belongs to the G-protein coupled receptor 1 family.

Protein type: Membrane protein, multi-pass; GPCR, family 1; Receptor, GPCR; Motility/polarity/chemotaxis; Membrane protein, integral

Chromosomal Location of Human Ortholog: 10q22.1

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: substance K receptor activity; protein binding; tachykinin receptor activity

Biological Process: negative regulation of luteinizing hormone secretion; tachykinin signaling pathway; intestine smooth muscle contraction; muscle contraction; operant conditioning; excretion; response to electrical stimulus; positive regulation of vascular permeability; positive regulation of acetylcholine secretion
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 Research Articles on TACR2    1. The occurrence of a profound alteration in NK receptor expression in RMDD is a novel finding that suggests NK-1R and NK-2R pathways as possible players in major depressive disorder.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-TACR2 antibodyPathways associated with anti-TACR2 antibody
 Reference Product  PubMed Publications
 TAC1 antibody  >7 publications with TACR2 and TAC1
 TAC4 antibody  >4 publications with TACR2 and TAC4
 TAC3 antibody  >2 publications with TACR2 and TAC3
 Products by Pathway  Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway antibodies  Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 G Alpha (q) Signalling Events Pathway antibodies  G Alpha (q) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 Gastrin-CREB Signalling Pathway Via PKC And MAPK antibodies  Gastrin-CREB Signalling Pathway Via PKC And MAPK Diagram
 Metabolic Disorders Of Biological Oxidation Enzymes Pathway antibodies  Metabolic Disorders Of Biological Oxidation Enzymes Pathway Diagram
Diseases associated with anti-TACR2 antibodyOrgans/Tissues associated with anti-TACR2 antibody
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >2 publications with TACR2 and Inflammation
 Nervous System Diseases Antibodies  >1 publications with TACR2 and Nervous System Diseases
 Brain Diseases Antibodies  >1 publications with TACR2 and Brain Diseases
 Hypertension Antibodies  >1 publications with TACR2 and Hypertension
 Necrosis Antibodies  >1 publications with TACR2 and Necrosis
 Organ/Tissue Name  Pubmed Publications
 Uterus Antibodies  >3 publications with TACR2 and Uterus
 Intestine Antibodies  >2 publications with TACR2 and Intestine
 Ovary Antibodies  >1 publications with TACR2 and Ovary
 Brain Antibodies  >1 publications with TACR2 and Brain
 Muscle Antibodies  >1 publications with TACR2 and Muscle
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