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anti-TACSTD2 antibody :: Rabbit TACSTD2 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS8240344
Unit / Price
0.03 mL  /  $155 +1 FREE 8GB USB
0.1 mL  /  $220 +1 FREE 8GB USB
0.2 mL  /  $295 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

TACSTD2, Polyclonal Antibody

★Popular Item★
 Also Known As   

Anti-TACSTD2 Antibody

 Product Synonym Names    GA733-1; M1S1; TROP2; Tumor-associated calcium signal transducer 2; Cell surface glycoprotein Trop-2; Membrane component chromosome 1 surface marker 1; Pancreatic carcinoma marker protein GA733-1
 Product Gene Name   

anti-TACSTD2 antibody

[Similar Products]
 Antibody/Peptide Pairs    TACSTD2 peptide (MBS8238320) is used for blocking the activity of TACSTD2 antibody (MBS8240344)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    137290
 3D Structure    ModBase 3D Structure for P09758
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat, Porcine
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 Specificity    Recognizes endogenous levels of TACSTD2 protein.
 Purity/Purification    The antibody was purified by immunogen affinity chromatography.
 Form/Format    Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
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 Immunogen    KLH-conjugated synthetic peptide encompassing a sequence within the center region of human TACSTD2. The exact sequence is proprietary.
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 Preparation and Storage    Shipped at 4C. Upon delivery aliquot and store at -20C for one year. Avoid freeze/thaw cycles.
 Other Notes    Small volumes of anti-TACSTD2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-TACSTD2 antibody

   Rabbit polyclonal antibody to TACSTD2
 Applications Tested/Suitable for anti-TACSTD2 antibody   

Western Blot (WB),Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

 Application Notes for anti-TACSTD2 antibody    WB (1/500 - 1/1000)
IHC (1/100 - 1/200)
IF/IC (1/100 - 1/500)
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 Western Blot (WB) of anti-TACSTD2 antibody    Western blot analysis of TACSTD2 expression in human prostate (A), NIH3T3 (B) whole cell lysates.
anti-TACSTD2 antibody Western Blot (WB) (WB) image
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 IHC of anti-TACSTD2 antibody    Immunohistochemical analysis of TACSTD2 staining in human lung cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugad compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.
anti-TACSTD2 antibody IHC image
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 IF of anti-TACSTD2 antibody    Immunofluorescent analysis of TACSTD2 staining in A549 cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 C in a hidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark. DAPI was used to stain the cell nuclei (blue).
anti-TACSTD2 antibody IF image
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NCBI/Uniprot data below describe general gene information for TACSTD2. It may not necessarily be applicable to this product.
 NCBI GI #    166795236
 NCBI GeneID    4070
 NCBI Accession #    NP_002344.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_002353.2 [Other Products]
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 UniProt Primary Accession #    P09758 [Other Products]
 UniProt Secondary Accession #    Q15658; Q6FG48; Q7Z7Q4; Q96QD2 [Other Products]
 UniProt Related Accession #    P09758 [Other Products]
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 NCBI Official Full Name    tumor-associated calcium signal transducer 2
 NCBI Official Synonym Full Names    tumor-associated calcium signal transducer 2
 NCBI Official Symbol    TACSTD2 [Similar Products]
 NCBI Official Synonym Symbols   
EGP1; GP50; M1S1; EGP-1; TROP2; GA7331; GA733-1
[Similar Products]
 NCBI Protein Information    tumor-associated calcium signal transducer 2
 UniProt Protein Name    Tumor-associated calcium signal transducer 2
 UniProt Synonym Protein Names   
Cell surface glycoprotein Trop-2; Membrane component chromosome 1 surface marker 1; Pancreatic carcinoma marker protein GA733-1
 Protein Family    Tumor-associated calcium signal transducer
 UniProt Gene Name    TACSTD2 [Similar Products]
 UniProt Synonym Gene Names    GA733-1; M1S1; TROP2 [Similar Products]
 UniProt Entry Name    TACD2_HUMAN
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 NCBI Summary for TACSTD2    This intronless gene encodes a carcinoma-associated antigen. This antigen is a cell surface receptor that transduces calcium signals. Mutations of this gene have been associated with gelatinous drop-like corneal dystrophy.[provided by RefSeq, Dec 2009]
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 UniProt Comments for TACSTD2    TACSTD2: May function as a growth factor receptor. Defects in TACSTD2 are the cause of gelatinous drop-like corneal dystrophy (GDLD); also known as lattice corneal dystrophy type III. GDLD is an autosomal recessive disorder characterized by grayish corneal amyloid deposits that cause severe visual impairment. Belongs to the EPCAM family.

Protein type: Membrane protein, integral; Receptor, misc.

Chromosomal Location of Human Ortholog: 1p32

Cellular Component: extracellular space; membrane; integral to plasma membrane; basal plasma membrane; nucleus; cytosol; lateral plasma membrane

Molecular Function: protein binding; receptor activity

Biological Process: cell proliferation; cell surface receptor linked signal transduction; negative regulation of stress fiber formation; visual perception; regulation of epithelial cell proliferation

Disease: Corneal Dystrophy, Gelatinous Drop-like
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 Research Articles on TACSTD2    1. Trop2 loss triggers sensitivity to anti-ErbB3 antibodies, which results in reduced proliferation and tumorigenic growth of Trop2 negative head and neck squamous cell cancer cells.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-TACSTD2 antibodyDiseases associated with anti-TACSTD2 antibody
 Reference Product  PubMed Publications
 CLDN1 antibody  >4 publications with TACSTD2 and CLDN1
 TJP1 antibody  >2 publications with TACSTD2 and TJP1
 CLDN7 antibody  >2 publications with TACSTD2 and CLDN7
 Disease Name  Pubmed Publications
 Adenocarcinoma Antibodies  >14 publications with TACSTD2 and Adenocarcinoma
 Prostatic Diseases Antibodies  >13 publications with TACSTD2 and Prostatic Diseases
 Prostatic Neoplasms Antibodies  >13 publications with TACSTD2 and Prostatic Neoplasms
 Breast Neoplasms Antibodies  >10 publications with TACSTD2 and Breast Neoplasms
 Neoplasms, Experimental Antibodies  >10 publications with TACSTD2 and Neoplasms, Experimental
 Corneal dystrophy, gelatinous drop-like Antibodies  >7 publications with TACSTD2 and Corneal dystrophy, gelatinous drop-like
 Lung Neoplasms Antibodies  >6 publications with TACSTD2 and Lung Neoplasms
 Disease Models, Animal Antibodies  >5 publications with TACSTD2 and Disease Models, Animal
 Ovarian Neoplasms Antibodies  >5 publications with TACSTD2 and Ovarian Neoplasms
 Ovarian Diseases Antibodies  >5 publications with TACSTD2 and Ovarian Diseases
Organs/Tissues associated with anti-TACSTD2 antibody
 Organ/Tissue Name  Pubmed Publications
 Eye Antibodies  >18 publications with TACSTD2 and Eye
 Prostate Antibodies  >15 publications with TACSTD2 and Prostate
 Liver Antibodies  >10 publications with TACSTD2 and Liver
 Lymph Node Antibodies  >10 publications with TACSTD2 and Lymph Node
 Lung Antibodies  >7 publications with TACSTD2 and Lung
 Bone Antibodies  >4 publications with TACSTD2 and Bone
 Skin Antibodies  >3 publications with TACSTD2 and Skin
 Embryonic Tissue Antibodies  >3 publications with TACSTD2 and Embryonic Tissue
 Bone Marrow Antibodies  >2 publications with TACSTD2 and Bone Marrow
 Intestine Antibodies  >2 publications with TACSTD2 and Intestine
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