NP_005631.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
transcription initiation factor TFIID subunit 4B
NCBI Official Synonym Full Names
TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa
NCBI Protein Information
transcription initiation factor TFIID subunit 4B; TAFII-105; TAF(II)105; TATA box binding protein (TBP)-associated factor 4B; transcription initiation factor TFIID 105 kD subunit; transcription initiation factor TFIID 105 kDa subunit; TATA box binding protein (TBP)-associated factor, RNA polymerase II, C2, 105kD
UniProt Protein Name
Transcription initiation factor TFIID subunit 4B
UniProt Synonym Protein Names
Transcription initiation factor TFIID 105 kDa subunit
UniProt Synonym Gene Names
UniProt Entry Name
TAF4B_HUMAN
NCBI Summary for TAF4B
TATA binding protein (TBP) and TBP-associated factors (TAFs) participate in the formation of the TFIID protein complex, which is involved in initiation of transcription of genes by RNA polymerase II. This gene encodes a cell type-specific TAF that may be responsible for mediating transcription by a subset of activators in B cells. [provided by RefSeq, Sep 2011]
UniProt Comments for TAF4B
TAF4B: Cell type-specific subunit of TFIID that may function as a gene-selective coactivator in certain cells. TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. TAFII105 is a transcriptional coactivator of the p65/RELA NF-kappa-B subunit. Involved in the activation of a subset of antiapoptotic genes including TNFAIP3. May be involved in regulating folliculogenesis. Through interaction with OCBA/POU2AF1, acts as a coactivator of B-cell-specific transcription. Belongs to the TAF4 family. 2 isoforms of the human protein are produced by alternative splicing.
Chromosomal Location of Human Ortholog: 18q11.2
Cellular Component: nucleoplasm; transcription factor TFIID complex; cytoplasm; nucleolus
Molecular Function: NF-kappaB binding; DNA binding; protein heterodimerization activity; transcription factor activity
Biological Process: transcription from RNA polymerase II promoter; oogenesis; transcription initiation from RNA polymerase II promoter; regulation of transcription, DNA-dependent; viral reproduction; RNA elongation from RNA polymerase II promoter; gene expression; spermatogenesis
Disease: Spermatogenic Failure 13
Research Articles on TAF4B
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Products associated with anti-TAF4B antibody
Pathways associated with anti-TAF4B antibody
Diseases associated with anti-TAF4B antibody
Organs/Tissues associated with anti-TAF4B antibody
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