Q9JHH6
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
thrombin-activatable fibrinolysis inhibitor
NCBI Official Synonym Full Names
carboxypeptidase B2 (plasma)
NCBI Official Synonym Symbols
CPR; Cpu; TAFI; AI255929; MGC107573; 1110032P04Rik; 4930405E17Rik [Similar Products]
NCBI Protein Information
carboxypeptidase B2; carboxypeptidase R; carboxypeptidase U; thrombin-activable fibrinolysis inhibitor; thrombin-activatable fibrinolysis inhibitor
UniProt Protein Name
Carboxypeptidase B2
UniProt Synonym Protein Names
Carboxypeptidase R; CPR; Carboxypeptidase U; CPU; Thrombin-activable fibrinolysis inhibitor
UniProt Synonym Gene Names
UniProt Entry Name
CBPB2_MOUSE
UniProt Comments for Cpb2
Function: Cleaves C-terminal arginine or lysine residues from biologically active peptides such as kinins or anaphylatoxins in the circulation thereby regulating their activities. Down-regulates fibrinolysis by removing C-terminal lysine residues from fibrin that has already been partially degraded by plasmin.
Catalytic activity: Release of C-terminal Arg and Lys from a polypeptide.
Cofactor: Binds 1 zinc ion per subunit
Enzyme regulation: TAFI/CPB2 is unique among carboxypeptidases in that it spontaneously inactivates with a short half-life, a property that is crucial for its role in controlling blood clot lysis. The zymogen is stabilized by interactions with the activation peptide. Release of the activation peptide increases a dynamic flap mobility and in time this leads to conformational changes that disrupt the catalytic site and expose a cryptic thrombin-cleavage site present at Arg-323
Subcellular location: Secreted Ref.2.
Tissue specificity: Plasma; synthesized in the liver. Ref.2
Sequence similarities: Belongs to the peptidase M14 family.
Product References and Citations for anti-Cpb2 antibody
1. Eaton, D.L., Malloy, B.E., Tsai, S.P., Henzel, W., Drayna, D., Isolation, Molecular Cloning and Partial Characterization of a Novel Carboxypeptidase B from Human Plasma. J.Biol.Chem. 266:21833-21838, 1991. 2. Hendriks, D., Scharpe, S., van Sande, M., Lommaert, M.P., Characterization of a carboxypeptidase in human serum distinct from carboxypeptidase N. J.Clin.Chem.Clin.BioChem. 27:277-285, 1989. 3. Campbell, W., Okada, J. An Arginine specific carboxypeptidase generated in blood during coagulation of inflammation which is unrelated to carboxypeptidase N or its subunits. Biochem.Biophys.Res.Commun. 162:933-939, 1989. 4. Bajzar, L., Morser, J., Nesheim, M.E. TAFI, or procarboxypeptidase B, couples the coagulation and fibrinolytic cascades through the thrombinthrombomodulin complex. J.Biol.Chem. 271:16603-16608, 1996.
Research Articles on Cpb2
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Pathways associated with anti-Cpb2 antibody
Diseases associated with anti-Cpb2 antibody
Organs/Tissues associated with anti-Cpb2 antibody
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