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anti-TAPBP antibody :: Rabbit anti-Human, Mouse TAPBP Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS9125502
Unit / Price
0.05 mL  /  $230 +1 FREE 8GB USB
0.1 mL  /  $305 +1 FREE 8GB USB
0.2 mL  /  $460 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

TAPBP, Polyclonal Antibody

★Popular Item★
 Also Known As   

TAPBP Polyclonal Antibody

 Product Synonym Names    TPN; TAPA; TPSN; NGS17
 Product Gene Name   

anti-TAPBP antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    601962
 3D Structure    ModBase 3D Structure for O15533
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse
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 Purity/Purification    Affinity Purification
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 Species    Human
 Category    Primary antibody
 Buffer    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
 Immunogen    Recombinant protein of human TAPBP
 Calculated Molecular Weight    47kDa
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 Preparation and Storage    Store at -20 degree C. Avoid freeze / thaw cycles.
 Other Notes    Small volumes of anti-TAPBP antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-TAPBP antibody

   This gene encodes a transmembrane glycoprotein which mediates interaction between newly assembled major histocompatibility complex (MHC) class I molecules and the transporter associated with antigen processing (TAP), which is required for the transport of antigenic peptides across the endoplasmic reticulum membrane. This interaction is essential for optimal peptide loading on the MHC class I molecule. Up to four complexes of MHC class I and this protein may be bound to a single TAP molecule. This protein contains a C-terminal double-lysine motif (KKKAE) known to maintain membrane proteins in the endoplasmic reticulum. This gene lies within the major histocompatibility complex on chromosome 6. Alternative splicing results in three transcript variants encoding different isoforms.
 Product Categories/Family for anti-TAPBP antibody    Polyclonal
 Applications Tested/Suitable for anti-TAPBP antibody   

Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

 Application Notes for anti-TAPBP antibody    WB: 1:500 - 1:2000
IHC: 1:50 - 1:200
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 Western Blot (WB) of anti-TAPBP antibody    Western blot analysis of extracts of HT-29 cells, using TAPBP antibody at 1:1000 dilution.
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (MBS128200) at 1:10000 dilution.
Lysates/proteins: 25ug per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Basic Kit.
Exposure time: 90s.
anti-TAPBP antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-TAPBP antibody    Immunohistochemistry of paraffin-embedded human stomach using TAPBP Antibody at dilution of 1:200 (40x lens).
anti-TAPBP antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-TAPBP antibody    Immunohistochemistry of paraffin-embedded rat testis using TAPBP Antibody at dilution of 1:200 (40x lens).
anti-TAPBP antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-TAPBP antibody    Immunohistochemistry of paraffin-embedded human gastric cancer using TAPBP Antibody at dilution of 1:200 (40x lens).
anti-TAPBP antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-TAPBP antibody    Immunohistochemistry of paraffin-embedded mouse testis using TAPBP Antibody at dilution of 1:200 (40x lens).
anti-TAPBP antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-TAPBP antibody    Immunohistochemistry of paraffin-embedded mouse kidney using TAPBP Antibody at dilution of 1:200 (40x lens).
anti-TAPBP antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for TAPBP. It may not necessarily be applicable to this product.
 NCBI GI #    12643361
 NCBI GeneID    6892
 NCBI Accession #    O15533.1 [Other Products]
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 UniProt Primary Accession #    O15533 [Other Products]
 UniProt Secondary Accession #    O15210; O15272; Q5STJ8; Q5STK6; Q5STQ5; A2AB91; A2ABC0; B0V003; B0V0A6; B2ZUA4; E9PGM2 [Other Products]
 UniProt Related Accession #    O15533 [Other Products]
 Molecular Weight    448
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 NCBI Official Full Name    Tapasin
 NCBI Official Synonym Full Names    TAP binding protein (tapasin)
 NCBI Official Symbol    TAPBP [Similar Products]
 NCBI Official Synonym Symbols   
TPN; TAPA; TPSN; NGS17
[Similar Products]
 NCBI Protein Information    tapasin; NGS-17; TAP-binding protein; TAP-associated protein
 UniProt Protein Name    Tapasin
 UniProt Synonym Protein Names   
NGS-17; TAP-associated protein; TAP-binding protein
 Protein Family    Tapasin
 UniProt Gene Name    TAPBP [Similar Products]
 UniProt Synonym Gene Names    NGS17; TAPA; TPN; TPSN [Similar Products]
 UniProt Entry Name    TPSN_HUMAN
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 NCBI Summary for TAPBP    This gene encodes a transmembrane glycoprotein which mediates interaction between newly assembled major histocompatibility complex (MHC) class I molecules and the transporter associated with antigen processing (TAP), which is required for the transport of antigenic peptides across the endoplasmic reticulum membrane. This interaction is essential for optimal peptide loading on the MHC class I molecule. Up to four complexes of MHC class I and this protein may be bound to a single TAP molecule. This protein contains a C-terminal double-lysine motif (KKKAE) known to maintain membrane proteins in the endoplasmic reticulum. This gene lies within the major histocompatibility complex on chromosome 6. Alternative splicing results in three transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
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 UniProt Comments for TAPBP    TAPBP: Involved in the association of MHC class I with transporter associated with antigen processing (TAP) and in the assembly of MHC class I with peptide (peptide loading). 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 6p21.3

Cellular Component: Golgi membrane; endoplasmic reticulum membrane; TAP complex; endoplasmic reticulum; integral to membrane

Molecular Function: protein binding; TAP1 binding; peptide antigen binding; MHC class I protein binding; unfolded protein binding; TAP2 binding; peptide antigen-transporting ATPase activity

Biological Process: peptide transport; antigen processing and presentation of peptide antigen via MHC class I; retrograde vesicle-mediated transport, Golgi to ER; peptide antigen stabilization; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; antigen processing and presentation of exogenous peptide antigen via MHC class I; protein complex assembly; immune response; amide transport; antigen processing and presentation of endogenous peptide antigen via MHC class I

Disease: Bare Lymphocyte Syndrome, Type I
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 Research Articles on TAPBP    1. Modified TAPBP gene function may contribute to the development of refractory chronic rhinosinusitis via reduction of circulating CD8 lymphocytes.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-TAPBP antibodyDiseases associated with anti-TAPBP antibody
 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Antigen Presentation: Folding, Assembly And Peptide Loading Of Class I MHC Pathway antibodies  Antigen Presentation: Folding, Assembly And Peptide Loading Of Class I MHC Pathway Diagram
 Antigen Processing And Presentation Pathway antibodies  Antigen Processing And Presentation Pathway Diagram
 Antigen Processing And Presentation Pathway antibodies  Antigen Processing And Presentation Pathway Diagram
 Antigen Processing-Cross Presentation Pathway antibodies  Antigen Processing-Cross Presentation Pathway Diagram
 Class I MHC Mediated Antigen Processing & Presentation Pathway antibodies  Class I MHC Mediated Antigen Processing & Presentation Pathway Diagram
 ER-Phagosome Pathway antibodies  ER-Phagosome Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Disease Name  Pubmed Publications
 Death Antibodies  >2 publications with TAPBP and Death
 Learning Disorders Antibodies  >1 publications with TAPBP and Learning Disorders
 Drug-Related Side Effects and Adverse Reactions Antibodies  >1 publications with TAPBP and Drug-Related Side Effects and Adverse Reactions
 Inflammation Antibodies  >1 publications with TAPBP and Inflammation
 Necrosis Antibodies  >1 publications with TAPBP and Necrosis
Organs/Tissues associated with anti-TAPBP antibody
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >5 publications with TAPBP and Blood
 Spleen Antibodies  >2 publications with TAPBP and Spleen
 Skin Antibodies  >1 publications with TAPBP and Skin
 Intestine Antibodies  >1 publications with TAPBP and Intestine
 Brain Antibodies  >1 publications with TAPBP and Brain
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