NP_001161750.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
WW domain-containing transcription regulator protein 1
NCBI Official Synonym Full Names
WW domain containing transcription regulator 1
NCBI Official Synonym Symbols
NCBI Protein Information
WW domain-containing transcription regulator protein 1
UniProt Protein Name
WW domain-containing transcription regulator protein 1
UniProt Synonym Protein Names
Transcriptional coactivator with PDZ-binding motif
UniProt Synonym Gene Names
UniProt Comments for TAZ
Transcriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. WWTR1 enhances PAX8 and NKX2-1/TTF1-dependent gene activation. Regulates the nuclear accumulation of SMADS and has a key role in coupling them to the transcriptional machinery such as the mediator complex. Regulates embryonic stem-cell self-renewal, promotes cell proliferation and epithelial-mesenchymal transition.
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Products associated with anti-TAZ antibody
Pathways associated with anti-TAZ antibody
Diseases associated with anti-TAZ antibody
Organs/Tissues associated with anti-TAZ antibody
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