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anti-TBCE antibody :: Rabbit anti-Human TBCE Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS8504567
Unit / Price
0.1 mg  /  $330 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

TBCE, Polyclonal Antibody

 Also Known As   

TBCE Antibody

 Product Gene Name   

anti-TBCE antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    604934
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human
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 Form/Format    TBCE antibody purified by protein affinity column containing 1% BSA and 0.02% NaN3
 Concentration    100ug/200ul (lot specific)
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 Source Note    Rabbit polyclonal TBCE(1) antibody was raised against a recombinate human TBCE protein 193-370aa (BC008654).
 Reactivity Note    Predicted: Mouse, Rat; Not yet tested in other species.
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 Preparation and Storage    Already reconstituted in 200ul sterile H2O. The antibody is stable for at least one year when stored at -20 degree C after reconstitution. Avoid repeated freeze/defrost cycles
 Other Notes    Small volumes of anti-TBCE antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-TBCE antibody    Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody
 Applications Tested/Suitable for anti-TBCE antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-TBCE antibody    ELISA titer: 1:20,000-1:80,000
Western blot analysis: 1:200-1:1,000
Immunohistochemistry: 1:100-1:500
Optimal dilutions/concentrations should be determined by the end use
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 Testing Data of anti-TBCE antibody    anti-TBCE antibody Testing Data image
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 Testing Data #2 of anti-TBCE antibody    anti-TBCE antibody Testing Data #2 image
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NCBI/Uniprot data below describe general gene information for TBCE. It may not necessarily be applicable to this product.
 NCBI GI #    568215738
 NCBI GeneID    6905
 NCBI Accession #    BC008654 [Other Products]
 NCBI GenBank Nucleotide #    NM_001287802.1 [Other Products]
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 UniProt Secondary Accession #    A8K8C2; B7Z3P1 [Other Products]
 UniProt Related Accession #    Q15813 [Other Products]
 Molecular Weight    64,852 Da
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 NCBI Official Full Name    tubulin-specific chaperone E isoform c
 NCBI Official Synonym Full Names    tubulin folding cofactor E
 NCBI Official Symbol    TBCE [Similar Products]
 NCBI Official Synonym Symbols   
HRD; KCS; KCS1; pac2
[Similar Products]
 NCBI Protein Information    tubulin-specific chaperone E; hypoparathyroidism, growth and mental retardation, and dysmorphism
 UniProt Protein Name    Tubulin-specific chaperone E
 UniProt Synonym Protein Names   
Tubulin-folding cofactor E
 Protein Family    Tubulin-specific chaperone
 UniProt Gene Name    TBCE [Similar Products]
 UniProt Entry Name    TBCE_HUMAN
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 NCBI Summary for TBCE    Cofactor E is one of four proteins (cofactors A, D, E, and C) involved in the pathway leading to correctly folded beta-tubulin from folding intermediates. Cofactors A and D are believed to play a role in capturing and stabilizing beta-tubulin intermediates in a quasi-native confirmation. Cofactor E binds to the cofactor D/beta-tubulin complex; interaction with cofactor C then causes the release of beta-tubulin polypeptides that are committed to the native state. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
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 UniProt Comments for TBCE    TBCE: Tubulin-folding protein; involved in the second step of the tubulin folding pathway. Seems to be implicated in the maintenance of the neuronal microtubule network. Involved in regulation of tubulin heterodimer dissociation. Defects in TBCE are a cause of hypoparathyroidism- retardation-dysmorphism syndrome (HRD); also known as hypoparathyroidism with short stature, mental retardation, and seizures or Sanjad-Sakati syndrome. HRD is an autosomal recessive disorder reported almost exclusively in Middle Eastern populations. Defects in TBCE are the cause of Kenny-Caffey syndrome type 1 (KCS1). KCS1 is similar to HRD with the additional features of osteosclerosis and recurrent bacterial infections. Belongs to the TBCE family.

Protein type: Chaperone

Chromosomal Location of Human Ortholog: 1q42.3

Cellular Component: microtubule; cytoplasm

Molecular Function: chaperone binding

Biological Process: developmental growth; 'de novo' posttranslational protein folding; cellular protein metabolic process; protein folding; adult locomotory behavior; muscle atrophy; microtubule cytoskeleton organization and biogenesis; post-chaperonin tubulin folding pathway; peripheral nervous system neuron axonogenesis; post-embryonic development

Disease: Hypoparathyroidism-retardation-dysmorphism Syndrome; Kenny-caffey Syndrome, Type 1
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 Research Articles on TBCE    1. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-TBCE antibodyPathways associated with anti-TBCE antibody
 Reference Product  PubMed Publications
 TBCA antibody  >6 publications with TBCE and TBCA
 TBCC antibody  >5 publications with TBCE and TBCC
 TBCD antibody  >5 publications with TBCE and TBCD
 TBCB antibody  >4 publications with TBCE and TBCB
 Products by Pathway  Pathway Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
 Post-chaperonin Tubulin Folding Pathway antibodies  Post-chaperonin Tubulin Folding Pathway Diagram
 Protein Folding Pathway antibodies  Protein Folding Pathway Diagram
Diseases associated with anti-TBCE antibodyOrgans/Tissues associated with anti-TBCE antibody
 Disease Name  Pubmed Publications
 Neurobehavioral Manifestations Antibodies  >13 publications with TBCE and Neurobehavioral Manifestations
 Kenny Caffey syndrome Antibodies  >6 publications with TBCE and Kenny Caffey syndrome
 Fetal Growth Retardation Antibodies  >3 publications with TBCE and Fetal Growth Retardation
 Hypoparathyroidism-retardation-dysmorphism syndrome Antibodies  >3 publications with TBCE and Hypoparathyroidism-retardation-dysmorphism syndrome
 Facies Antibodies  >3 publications with TBCE and Facies
 Kenny-Caffey syndrome, Type 1 Antibodies  >2 publications with TBCE and Kenny-Caffey syndrome, Type 1
 Bacterial Infections Antibodies  >2 publications with TBCE and Bacterial Infections
 Craniofacial Abnormalities Antibodies  >2 publications with TBCE and Craniofacial Abnormalities
 Weight Loss Antibodies  >1 publications with TBCE and Weight Loss
 Neurotoxicity Syndromes Antibodies  >1 publications with TBCE and Neurotoxicity Syndromes
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >4 publications with TBCE and Brain
 Eye Antibodies  >3 publications with TBCE and Eye
 Muscle Antibodies  >3 publications with TBCE and Muscle
 Bone Antibodies  >2 publications with TBCE and Bone
 Blood Antibodies  >2 publications with TBCE and Blood
 Ovary Antibodies  >1 publications with TBCE and Ovary
 Stomach Antibodies  >1 publications with TBCE and Stomach
 Pharynx Antibodies  >1 publications with TBCE and Pharynx
 Embryonic Tissue Antibodies  >1 publications with TBCE and Embryonic Tissue
 Testis Antibodies  >1 publications with TBCE and Testis
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