Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
1.855.MyBioSource
Fax 1.858.633.0166    Email sales@mybiosource.com 
tel/fax
menu1 Home Products Ordering Company Help menu7
bottom
   MyBioSource rightarrow Antibody rightarrow HNF1A rightarrow Polyclonal HNF1A  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Menu separator
separator
ELISA Kit ELISA Kit
CLIA Kit CLIA Kit
PCR Kit PCR Kit
Monoclonal Antibody Monoclonal Antibody
Polyclonal Antibody Polyclonal Antibody
Secondary Antibody Secondary Antibody
Antigen Antigen
Biochemical Biochemical
cDNA Clone cDNA Clone
siRNA siRNA
Peptide Peptide
Recombinant/Purified Protein Rec./Purified Protein

Custom ELISA Kit Custom ELISA Kit
Custom Protein Custom Protein
Custom Antibody Custom Antibody
Antibody Matched Pairs Antibody Matched Pairs
Antibody & Corresponding Blocking Peptide Pairs Antibody Peptide Pairs
Phospho-Specific Antibodies Phospho Antibodies
Products by Disease Products by Disease
Products by Pathway Products by Pathway
Products by Tissue Products by Tissue

arrow Advanced Search
arrow Submit Technical Q&A
arrow International Distributors
arrow Contact Us
separator
Our Best Sellers moreseparator
separator
 • Myeloid Progenitor Inhibitory Factor 1 (MPIF-1) ELISA Kit
 • Heterogeneous Nuclear Ribonucleoprotein A1 (hnRNP A1) ELISA Kit
 • Glucuronidase Beta (GUSbeta) ELISA Kit
 • Cav1.2 alpha1c (Prkg2) Antibody
 • V-Myc Myelocytomatosis Viral Oncogene Homolog (MYC) Recombinant Protein
 • Transforming Growth Factor Beta Induced (TGFbI) ELISA Kit
 • DRP-2 (Ab-514) Antibody
 • Complement Factor D (CFD) ELISA Kit
 • Myosin Heavy Chain 3, Skeletal Muscle, Embryonic (MYH3) ELISA Kit
 • ALG9 Antibody
 • MHC Class I Antibody
 • B-Lymphocyte Chemoattractant 1 (BLC1) Recombinant Protein
 • GAPR1 (GLIPR2) Antibody
 • Endothelial Cell Antibody (AECA) ELISA Kit
 downarrow more ...
separator
separator
DatasheetFull DatasheetPrinter Friendly DatasheetPrint This DatasheetAdd to Compare ListHave Questions? Ask UsRequest for a Quotation today

anti-HNF1A antibody :: Goat TCF1/HNF1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS420686 anti-HNF1A antibody
Unit / Price
0.1 mg  /  $225 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

TCF1/HNF1 (HNF1A), Polyclonal Antibody

 Also Known As   

Goat anti-TCF1/HNF1 Antibody

 Product Synonym Names    Goat Anti-HNF1A Antibody; TCF1; transcription factor 1, hepatic LF-B1, hepatic nuclear factor (HNF1), albumin proximal factor; HNF1; HNF1A; LFB1; MODY3; Interferon production regulator factor (HNF1); albumin proximal factor; hepatic nuclear factor 1; maturity onset diabetes of t; TCF1 antibody; transcription factor 1; hepatic LF-B1; hepatic nuclear factor (HNF1); albumin proximal factor antibody; HNF1 antibody; HNF1A antibody; LFB1 antibody; MODY3 antibody; Interferon production regulator factor (HNF1) antibody; albumin proximal factor antibody; hepatic nuclear factor 1 antibody; maturity onset diabetes of the young 3 antibody; transcription factor 1; hepatic antibody; TCF1 / HNF1
 Product Gene Name   

anti-HNF1A antibody

[Similar Products]
 Product Synonym Gene Name    TCF1; HNF1 [Similar Products]
 Antibody/Peptide Pairs    TCF1 / HNF1 peptide (MBS426440) is used for blocking the activity of TCF1/HNF1 antibody (MBS420686)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
Table BarTOPTable Bar
 Immunogen Sequence    DELPTKKGRR NRFK
 OMIM    142330
Section Bar
 Clonality    Polyclonal
 Host    Goat
 Species Reactivity    Expected from sequence similarity: Human, Mouse, Rat, Dog
Section Bar
 Purity/Purification    Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
 Form/Format    Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
 Concentration    100ug specific antibody in 200ul (lot specific)
Section Bar
 Immunogen    Peptide with sequence C-DELPTKKGRRNRFK, from the internal region of the protein sequence according to NP_000536.3.
 Epitope    Internal region
Section Bar
 Preparation and Storage    Aliquot and store at -20 degree C. Minimize freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of anti-HNF1A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Table BarTOPTable Bar
 Applications Tested/Suitable for anti-HNF1A antibody   

Peptide ELISA (EIA)

 Application Notes for anti-HNF1A antibody    Peptide ELISA: Antibody detection limit dilution 1: 4000.
Western Blot: Preliminary experiments in human liver and kidney lysates gave no specific signal but low background (at antibody concentration up to 1ug/ml).
Table BarTOPTable Bar
NCBI/Uniprot data below describe general gene information for HNF1A. It may not necessarily be applicable to this product.
 NCBI GI #    38016909
 NCBI GeneID    6927
 NCBI Accession #    NP_000536.3 [Other Products]
 NCBI GenBank Nucleotide #    NM_000545.3 [Other Products]
Section Bar
 UniProt Secondary Accession #    Q2M3H2; Q99861; A5Z2R8; E0YMJ5; E0YMK0; E0YMK1; E2I9R4; E2I9R5; F5H5U3 [Other Products]
 UniProt Related Accession #    P20823 [Other Products]
 Molecular Weight    12,491 Da
Table BarTOPTable Bar
 NCBI Official Full Name    transcription factor 1, hepatic
 NCBI Official Synonym Full Names    HNF1 homeobox A
 NCBI Official Symbol    HNF1A [Similar Products]
 NCBI Official Synonym Symbols   
HNF1; LFB1; TCF1; MODY3; TCF-1; HNF-1A; IDDM20
[Similar Products]
 NCBI Protein Information    hepatocyte nuclear factor 1-alpha
 UniProt Protein Name    Hepatocyte nuclear factor 1-alpha
 UniProt Synonym Protein Names   
Liver-specific transcription factor LF-B1; LFB1; Transcription factor 1; TCF-1
 Protein Family    Hepatocyte nuclear factor
 UniProt Gene Name    HNF1A [Similar Products]
 UniProt Synonym Gene Names    TCF1; HNF-1-alpha; HNF-1A; LFB1; TCF-1 [Similar Products]
 UniProt Entry Name    HNF1A_HUMAN
Section Bar
 NCBI Summary for HNF1A    The protein encoded by this gene is a transcription factor required for the expression of several liver-specific genes. The encoded protein functions as a homodimer and binds to the inverted palindrome 5'-GTTAATNATTAAC-3'. Defects in this gene are a cause of maturity onset diabetes of the young type 3 (MODY3) and also can result in the appearance of hepatic adenomas. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]
Section Bar
 UniProt Comments for HNF1A    HNF1A: Transcriptional activator that regulates the tissue specific expression of multiple genes, especially in pancreatic islet cells and in liver. Required for the expression of several liver specific genes. Binds to the inverted palindrome 5'- GTTAATNATTAAC-3'. Defects in HNF1A are a cause of hepatic adenomas familial (HEPAF). Hepatic adenomas are rare benign liver tumors of presumable epithelial origin that develop in an otherwise normal liver. Hepatic adenomas may be single or multiple. They consist of sheets of well-differentiated hepatocytes that contain fat and glycogen and can produce bile. Bile ducts or portal areas are absent. Kupffer cells, if present, are reduced in number and are non-functional. Conditions associated with adenomas are insulin-dependent diabetes mellitus and glycogen storage diseases (types 1 and 3). Bi-allelic inactivation of HNF1A, whether sporadic or associated with MODY3, may be an early step in the developmant of some hepatocellular carcinomas. Defects in HNF1A are the cause of maturity-onset diabetes of the young type 3 (MODY3); also symbolized MODY-3. MODY is a form of diabetes that is characterized by an autosomal dominant mode of inheritance, onset in childhood or early adulthood (usually before 25 years of age), a primary defect in insulin secretion and frequent insulin-independence at the beginning of the disease. Defects in HNF1A are the cause of susceptibility to diabetes mellitus insulin-dependent type 20 (IDDM20). IDDM20 is a multifactorial disorder of glucose homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy. Clinical fetaures are polydipsia, polyphagia and polyuria which result from hyperglycemia-induced osmotic diuresis and secondary thirst. These features can result in long-term complications that affect the eyes, kidneys, nerves, and blood vessels. Belongs to the HNF1 homeobox family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: DNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: 12q24.2

Cellular Component: cytoplasm; nucleus; protein complex

Molecular Function: DNA binding; protein binding; protein dimerization activity; protein heterodimerization activity; protein homodimerization activity; transcription factor activity

Biological Process: glucose homeostasis; glucose import; insulin secretion; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; regulation of transcription from RNA polymerase II promoter; transcription from RNA polymerase II promoter

Disease: Diabetes Mellitus, Insulin-dependent; Diabetes Mellitus, Insulin-dependent, 20; Diabetes Mellitus, Noninsulin-dependent; Hepatic Adenomas, Familial; Maturity-onset Diabetes Of The Young, Type 3; Renal Cell Carcinoma, Nonpapillary
Table BarTOPTable Bar
 Research Articles on HNF1A    1. a pathway in which TNFalpha-NF-kappaB signaling switches off negative regulation by suppressing HNF-1alpha-mediated expression of miR-194, revealing insight into the mechanisms linking inflammatory pathways, miRNA, and HCC metastasis.
Table BarTOPTable Bar
 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Table BarTOPTable Bar
Products related to Goat anti-TCF1/HNF1 Antibody
 Catalog #  Product Name
 MBS420686  Goat anti-TCF1/HNF1 Antibody
Products associated with anti-HNF1A antibodyPathways associated with anti-HNF1A antibody
 Reference Product  PubMed Publications
 HNF4A antibody  >255 publications with HNF1A and HNF4A
 CTNNB1 antibody  >123 publications with HNF1A and CTNNB1
 PDX1 antibody  >23 publications with HNF1A and PDX1
 ONECUT1 antibody  >15 publications with HNF1A and ONECUT1
 SLC2A2 antibody  >11 publications with HNF1A and SLC2A2
 HNF4G antibody  >9 publications with HNF1A and HNF4G
 CREBBP antibody  >5 publications with HNF1A and CREBBP
 PCBD1 antibody  >1 publications with HNF1A and PCBD1
 HDAC1 antibody  >1 publications with HNF1A and HDAC1
 DYRK1B antibody  >1 publications with HNF1A and DYRK1B
 Products by Pathway  Pathway Diagram
 Adipogenesis Pathway antibodies  Adipogenesis Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 FOXA2 And FOXA3 Transcription Factor Networks Pathway antibodies  FOXA2 And FOXA3 Transcription Factor Networks Pathway Diagram
 IL-6 Signaling Pathway antibodies  IL-6 Signaling Pathway Diagram
 Maturity Onset Diabetes Of The Young Pathway antibodies  Maturity Onset Diabetes Of The Young Pathway Diagram
 Maturity Onset Diabetes Of The Young Pathway antibodies  Maturity Onset Diabetes Of The Young Pathway Diagram
 Presenilin Action In Notch And Wnt Signaling Pathway antibodies  Presenilin Action In Notch And Wnt Signaling Pathway Diagram
 Regulation Of Beta-cell Development Pathway antibodies  Regulation Of Beta-cell Development Pathway Diagram
 Regulation Of Gene Expression In Beta Cells Pathway antibodies  Regulation Of Gene Expression In Beta Cells Pathway Diagram
 Signaling Pathways Regulating Pluripotency Of Stem Cells antibodies  Signaling Pathways Regulating Pluripotency Of Stem Cells Diagram
Diseases associated with anti-HNF1A antibodyOrgans/Tissues associated with anti-HNF1A antibody
 Disease Name  Pubmed Publications
 Diabetes Mellitus, Type 2 Antibodies  >447 publications with HNF1A and Diabetes Mellitus, Type 2
 Liver Diseases Antibodies  >210 publications with HNF1A and Liver Diseases
 Liver Neoplasms Antibodies  >163 publications with HNF1A and Liver Neoplasms
 Carcinoma, Hepatocellular Antibodies  >97 publications with HNF1A and Carcinoma, Hepatocellular
 Hyperglycemia Antibodies  >86 publications with HNF1A and Hyperglycemia
 Diabetes Mellitus, Type 1 Antibodies  >84 publications with HNF1A and Diabetes Mellitus, Type 1
 Disease Models, Animal Antibodies  >70 publications with HNF1A and Disease Models, Animal
 Inflammation Antibodies  >66 publications with HNF1A and Inflammation
 Adenoma, Liver Cell Antibodies  >49 publications with HNF1A and Adenoma, Liver Cell
 Kidney Diseases Antibodies  >40 publications with HNF1A and Kidney Diseases
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >582 publications with HNF1A and Liver
 Kidney Antibodies  >130 publications with HNF1A and Kidney
 Intestine Antibodies  >91 publications with HNF1A and Intestine
 Stomach Antibodies  >12 publications with HNF1A and Stomach
 Mixed Antibodies  >8 publications with HNF1A and Mixed
 Eye Antibodies  >6 publications with HNF1A and Eye
Table BarTOPTable Bar
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions