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anti-TCIRG1 antibody :: Rabbit TCIRG1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS150138
Western Blot (WB)
Unit / Price
0.1 mg  /  $365 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

TCIRG1, Polyclonal Antibody

 Also Known As   

TCIRG1 Antibody

 Product Synonym Names    TCIRG1; a3; Stv1; Vph1; Atp6i; OC116; OPTB1; TIRC7; ATP6N1C; ATP6V0A3; OC-116kDa; V-type proton ATPase 116 kDa subunit a isoform 3; Osteoclastic proton pump 116 kDa subunit; V-ATPase 116 kDa isoform a3; T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3
 Product Gene Name   

anti-TCIRG1 antibody

[Similar Products]
 Antibody/Peptide Pairs    TCIRG1 peptide (MBS152543) is used for blocking the activity of TCIRG1 antibody (MBS150138)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    phenotype 604592
 3D Structure    ModBase 3D Structure for Q13488
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Specificity    At least two alternatively spliced isoforms are known to exist; this antibody will only detect the larger isoform.
 Purity/Purification    TCIRG1 Antibody is affinity chromatography purified via peptide column.
 Form/Format    Liquid
 Concentration    1 mg/mL (lot specific)
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 Conjugate    Unconjugated
 Immunogen    TCIRG1 antibody was raised against a 19 amino acid synthetic peptide near the amino terminus of human TCIRG1.
 Buffer    TCIRG1 Antibody is supplied in PBS containing 0.02% sodium azide.
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 Preparation and Storage    TCIRG1 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
 Other Notes    Small volumes of anti-TCIRG1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-TCIRG1 antibody

   TCIRG1 Antibody: The T-cell immune regulator 1 (TCIRG1) is the a3 subunit of the vacuolar-type proton transporting ATPase (V-ATPase), a proton pump in late endosomes and lysosomes that functions in the luminal acidification of these organelles. Genetic defects in the gene encoding this protein a responsible for a severe form of autosomal recessive osteopetrosis, a condition that leads to increased bone density, decreased bone strength, and inflammation in bone tissues. TCIRG1 is also required for the normal secretion of insulin and the bacteria-killing function of macrophages.
 Applications Tested/Suitable for anti-TCIRG1 antibody   

ELISA (EIA), Western Blot (WB)

 Application Notes for anti-TCIRG1 antibody    TCIRG1 antibody can be used for detection of TCIRG1 by Western blot at 0.5 mug/mL.
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 Western Blot (WB) of anti-TCIRG1 antibody    Western blot analysis of TCIRG1 in EL4 cell lysate with TCIRG1 antibody at 0.5 μg/ml in (A) the absence and (B) the presence of blocking peptide.
anti-TCIRG1 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for TCIRG1. It may not necessarily be applicable to this product.
 NCBI GI #    19924145
 NCBI GeneID    10312
 NCBI Accession #    NP_006010 [Other Products]
 NCBI GenBank Nucleotide #    NM_006019.3 [Other Products]
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 UniProt Primary Accession #    Q13488 [Other Products]
 UniProt Secondary Accession #    O75877; Q8WVC5 [Other Products]
 UniProt Related Accession #    Q13488 [Other Products]
 Molecular Weight    91 kDa
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 NCBI Official Full Name    V-type proton ATPase 116 kDa subunit a isoform 3 isoform a
 NCBI Official Synonym Full Names    T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3
 NCBI Official Symbol    TCIRG1 [Similar Products]
 NCBI Official Synonym Symbols   
a3; Stv1; Vph1; Atp6i; OC116; OPTB1; TIRC7; ATP6N1C; ATP6V0A3; OC-116kDa
[Similar Products]
 NCBI Protein Information    V-type proton ATPase 116 kDa subunit a isoform 3; OC-116 kDa; V-ATPase 116-kDa; T-cell immune response cDNA 7; ATPase, H+ transporting, 116kD; osteoclastic proton pump 116 kDa subunit; specific 116-kDa vacuolar proton pump subunit; vacuolar proton translocating ATPase 116 kDa subunit A; T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 protein a
 UniProt Protein Name    V-type proton ATPase 116 kDa subunit a isoform 3
 UniProt Synonym Protein Names   
Osteoclastic proton pump 116 kDa subunit; OC-116 kDa; OC116; T-cell immune regulator 1; T-cell immune response cDNA7 protein; TIRC7; Vacuolar proton translocating ATPase 116 kDa subunit a isoform 3
 Protein Family    V-type proton ATPase
 UniProt Gene Name    TCIRG1 [Similar Products]
 UniProt Synonym Gene Names    ATP6N1C; ATP6V0A3; V-ATPase 116 kDa isoform a3; OC-116 kDa; OC116; TIRC7 [Similar Products]
 UniProt Entry Name    VPP3_HUMAN
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 NCBI Summary for TCIRG1    Through alternate splicing, this gene encodes two proteins with similarity to subunits of the vacuolar ATPase (V-ATPase) but the encoded proteins seem to have different functions. V-ATPase is a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, and receptor-mediated endocytosis. V-ATPase is comprised of a cytosolic V1 domain and a transmembrane V0 domain. Mutations in this gene are associated with infantile malignant osteopetrosis. [provided by RefSeq, Jul 2008]
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 UniProt Comments for TCIRG1    TCIRG1: Part of the proton channel of V-ATPases. Seems to be directly involved in T-cell activation. Defects in TCIRG1 are the cause of osteopetrosis autosomal recessive type 1 (OPTB1); also called autosomal recessive Albers-Schonberg disease or infantile malignant osteopetrosis. Osteopetrosis is a rare genetic disease characterized by abnormally dense bone, due to defective resorption of immature bone. The disorder occurs in two forms: a severe autosomal recessive form occurring in utero, infancy, or childhood, and a benign autosomal dominant form occurring in adolescence or adulthood. The features of OPTB1 are macrocephaly, progressive deafness and blindness, hepatosplenomegaly, and severe anemia beginning in early infancy or in fetal life. Deafness and blindness are generally thought to represent effects of pressure on nerves. Belongs to the V-ATPase 116 kDa subunit family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Transporter, iron; Energy Metabolism - oxidative phosphorylation; Mitochondrial; Transporter; Transporter, ion channel; Membrane protein, multi-pass; Membrane protein, integral

Chromosomal Location of Human Ortholog: 11q13.2

Cellular Component: phagocytic vesicle membrane; mitochondrion; integral to plasma membrane; lysosomal membrane; apical plasma membrane; plasma membrane; endosome membrane; vacuolar proton-transporting V-type ATPase complex

Molecular Function: transporter activity; hydrogen ion transporting ATPase activity, rotational mechanism; ATPase binding

Biological Process: interaction with host; vacuolar acidification; proton transport; ATP synthesis coupled proton transport; cellular iron ion homeostasis; ATP hydrolysis coupled proton transport; positive regulation of cell proliferation; insulin receptor signaling pathway; cellular defense response; transferrin transport; transmembrane transport

Disease: Osteopetrosis, Autosomal Recessive 1
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 Research Articles on TCIRG1    1. TCIRG1-associated congenital neutropenia.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-TCIRG1 antibodyPathways associated with anti-TCIRG1 antibody
 Reference Product  PubMed Publications
 ATP6V1A antibody  >1 publications with TCIRG1 and ATP6V1A
 ATP6V0C antibody  >1 publications with TCIRG1 and ATP6V0C
 ATP6V1B1 antibody  >1 publications with TCIRG1 and ATP6V1B1
 Products by Pathway  Pathway Diagram
 Collecting Duct Acid Secretion Pathway antibodies  Collecting Duct Acid Secretion Pathway Diagram
 Collecting Duct Acid Secretion Pathway antibodies  Collecting Duct Acid Secretion Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Epithelial Cell Signaling In Helicobacter Pylori Infection Pathway antibodies  Epithelial Cell Signaling In Helicobacter Pylori Infection Pathway Diagram
 Epithelial Cell Signaling In Helicobacter Pylori Infection Pathway antibodies  Epithelial Cell Signaling In Helicobacter Pylori Infection Pathway Diagram
 Insulin Receptor Recycling Pathway antibodies  Insulin Receptor Recycling Pathway Diagram
 Iron Uptake And Transport Pathway antibodies  Iron Uptake And Transport Pathway Diagram
 Latent Infection Of Homo Sapiens With Mycobacterium Tuberculosis Pathway antibodies  Latent Infection Of Homo Sapiens With Mycobacterium Tuberculosis Pathway Diagram
 Lysosome Pathway antibodies  Lysosome Pathway Diagram
 Lysosome Pathway antibodies  Lysosome Pathway Diagram
Diseases associated with anti-TCIRG1 antibodyOrgans/Tissues associated with anti-TCIRG1 antibody
 Disease Name  Pubmed Publications
 Death Antibodies  >7 publications with TCIRG1 and Death
 Necrosis Antibodies  >5 publications with TCIRG1 and Necrosis
 Congenital Abnormalities Antibodies  >4 publications with TCIRG1 and Congenital Abnormalities
 Splenomegaly Antibodies  >3 publications with TCIRG1 and Splenomegaly
 Kidney Diseases Antibodies  >2 publications with TCIRG1 and Kidney Diseases
 Inflammation Antibodies  >2 publications with TCIRG1 and Inflammation
 Carcinoma Antibodies  >2 publications with TCIRG1 and Carcinoma
 Lung Neoplasms Antibodies  >1 publications with TCIRG1 and Lung Neoplasms
 Liver Diseases Antibodies  >1 publications with TCIRG1 and Liver Diseases
 Hemorrhage Antibodies  >1 publications with TCIRG1 and Hemorrhage
 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >70 publications with TCIRG1 and Bone
 Blood Antibodies  >23 publications with TCIRG1 and Blood
 Bone Marrow Antibodies  >19 publications with TCIRG1 and Bone Marrow
 Brain Antibodies  >7 publications with TCIRG1 and Brain
 Liver Antibodies  >6 publications with TCIRG1 and Liver
 Nerve Antibodies  >6 publications with TCIRG1 and Nerve
 Connective Tissue Antibodies  >5 publications with TCIRG1 and Connective Tissue
 Kidney Antibodies  >4 publications with TCIRG1 and Kidney
 Spleen Antibodies  >4 publications with TCIRG1 and Spleen
 Eye Antibodies  >2 publications with TCIRG1 and Eye
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