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anti-TCL1A antibody :: Rabbit anti-Human, Rat TCL1A Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS125753
Unit / Price
0.05 mL  /  $230 +1 FREE 8GB USB
0.1 mL  /  $305 +1 FREE 8GB USB
0.2 mL  /  $460 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

TCL1A, Polyclonal Antibody

 Also Known As   

TCL1A Polyclonal Antibody

 Product Synonym Names    TCL1A; TCL1
 Product Gene Name   

anti-TCL1A antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    186960
 3D Structure    ModBase 3D Structure for P56279
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Rat
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 Purity/Purification    Affinity Purification
 Concentration    1mg/ml (lot specific)
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 Species    Human
 Immunogen    Recombinant Protein
 Immunogen    Recombinant protein of human TCL1A
 Calculated Molecular Weight    13kDa
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 Preparation and Storage    Store at -20 degree C (regular) or -80 degree C (long term). Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
 Other Notes    Small volumes of anti-TCL1A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-TCL1A antibody

   TCL1 (T cell leukemia 1), MTCP1 and TCL1b belong to the TCL1 proto-oncogene family, and their products are involved in Akt activation during embryonic development, T cell leukemias, prolymphocytic leukemias and B cell lymphomas (1-3). The Akt association domain of TCL1 binds with the PH domain of Akt. The formation of an oligomeric TCL-Akt complex is required for TCL1 coactivator function and results in phosphorylation and activation of Akt. Furthermore, functional analysis indicates that the interaction between TCL1 and Akt promotes translocation of Akt to the nucleus (4-6). These findings are supported by the crystal structure of TCL1, which suggests that TCL1 may participate in molecular transport (7).
 Product Categories/Family for anti-TCL1A antibody    Polyclonal
 Applications Tested/Suitable for anti-TCL1A antibody   

Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

 Application Notes for anti-TCL1A antibody    WB: 1:500 - 1:2000
IHC: 1:50 - 1:200
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 Western Blot (WB) of anti-TCL1A antibody    Western blot analysis of Ramos cell lysate using TCL1A antibody.
anti-TCL1A antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC of anti-TCL1A antibody    Immunohistochemistry of paraffin-embedded rat brain using TCL1A antibody at dilution of 1:100 (400x lens).
anti-TCL1A antibody Immunohistochemistry (IHC (IHC) image
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 Immunohistochemistry (IHC) of anti-TCL1A antibody    Immunohistochemistry of paraffin-embedded rat lung using TCL1A antibody at dilution of 1:100 (200x lens).
anti-TCL1A antibody Immunohistochemistry (IHC) (IHC) image
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 Immunofluorescence (IF) of anti-TCL1A antibody    Immunofluorescence analysis of U2OS cell using TCL1A antibody. Blue: DAPI for nuclear staining.
anti-TCL1A antibody Immunofluorescence (IF) image
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NCBI/Uniprot data below describe general gene information for TCL1A. It may not necessarily be applicable to this product.
 NCBI GI #    3024699
 NCBI GeneID    8115
 NCBI Accession #    P56279.1 [Other Products]
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 UniProt Primary Accession #    P56279 [Other Products]
 UniProt Secondary Accession #    Q6IBK7 [Other Products]
 UniProt Related Accession #    P56279 [Other Products]
 Molecular Weight    114
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 NCBI Official Full Name    T-cell leukemia/lymphoma protein 1A
 NCBI Official Synonym Full Names    T-cell leukemia/lymphoma 1A
 NCBI Official Symbol    TCL1A [Similar Products]
 NCBI Official Synonym Symbols   
TCL1
[Similar Products]
 NCBI Protein Information    T-cell leukemia/lymphoma protein 1A; oncogene TCL1; oncogene TCL-1; protein p14 TCL1; T-cell lymphoma-1
 UniProt Protein Name    T-cell leukemia/lymphoma protein 1A
 UniProt Synonym Protein Names   
Oncogene TCL-1; Oncogene TCL1; Protein p14 TCL1
 Protein Family    T-cell leukemia/lymphoma protein
 UniProt Gene Name    TCL1A [Similar Products]
 UniProt Synonym Gene Names    TCL1; Oncogene TCL1 [Similar Products]
 UniProt Entry Name    TCL1A_HUMAN
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 NCBI Summary for TCL1A    Overexpression of the TCL1 gene in humans has been implicated in the development of mature T cell leukemia, in which chromosomal rearrangements bring the TCL1 gene in close proximity to the T-cell antigen receptor (TCR)-alpha (MIM 186880) or TCR-beta (MIM 186930) regulatory elements (summarized by Virgilio et al., 1998 [PubMed 9520462]). In normal T cells TCL1 is expressed in CD4-/CD8- cells, but not in cells at later stages of differentiation. TCL1 functions as a coactivator of the cell survival kinase AKT (MIM 164730) (Laine et al., 2000 [PubMed 10983986]).[supplied by OMIM, Jul 2010]
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 UniProt Comments for TCL1A    TCL1A: Enhances the phosphorylation and activation of AKT1, AKT2 and AKT3. Promotes nuclear translocation of AKT1. Enhances cell proliferation, stabilizes mitochondrial membrane potential and promotes cell survival. Homodimer. Interacts with AKT1, AKT2 and AKT3 (via PH domain). Interacts with PNPT1; the interaction has no effect on PNPT1 exonuclease activity. Restricted in the T-cell lineage to immature thymocytes and activated peripheral lymphocytes. Preferentially expressed early in T- and B-lymphocyte differentiation. Belongs to the TCL1 family.

Protein type: Oncoprotein; Protein kinase, regulatory subunit

Chromosomal Location of Human Ortholog: 14q32.1

Cellular Component: endoplasmic reticulum; pronucleus; cell cortex

Molecular Function: protein binding

Biological Process: multicellular organismal development; stem cell maintenance
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 Research Articles on TCL1A    1. Report frequent TCL1A rearrangements in T-cell prolymphocytic leukemia with cutaneous involvement.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-TCL1A antibodyPathways associated with anti-TCL1A antibody
 Reference Product  PubMed Publications
 AKT1 antibody  >12 publications with TCL1A and AKT1
 JUN antibody  >11 publications with TCL1A and JUN
 ATM antibody  >7 publications with TCL1A and ATM
 CD19 antibody  >4 publications with TCL1A and CD19
 FOS antibody  >3 publications with TCL1A and FOS
 TCL6 antibody  >2 publications with TCL1A and TCL6
 CD79A antibody  >1 publications with TCL1A and CD79A
 AKT3 antibody  >1 publications with TCL1A and AKT3
 AKT2 antibody  >1 publications with TCL1A and AKT2
 Products by Pathway  Pathway Diagram
 PI3K-Akt Signaling Pathway antibodies  PI3K-Akt Signaling Pathway Diagram
 PI3K-Akt Signaling Pathway antibodies  PI3K-Akt Signaling Pathway Diagram
Diseases associated with anti-TCL1A antibodyOrgans/Tissues associated with anti-TCL1A antibody
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >10 publications with TCL1A and Nervous System Diseases
 Brain Diseases Antibodies  >6 publications with TCL1A and Brain Diseases
 Lung Diseases Antibodies  >1 publications with TCL1A and Lung Diseases
 Lymphadenitis Antibodies  >1 publications with TCL1A and Lymphadenitis
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >68 publications with TCL1A and Blood
 Bone Antibodies  >21 publications with TCL1A and Bone
 Bone Marrow Antibodies  >18 publications with TCL1A and Bone Marrow
 Lymph Node Antibodies  >15 publications with TCL1A and Lymph Node
 Lymph Antibodies  >12 publications with TCL1A and Lymph
 Tonsil Antibodies  >2 publications with TCL1A and Tonsil
 Placenta Antibodies  >1 publications with TCL1A and Placenta
 Lung Antibodies  >1 publications with TCL1A and Lung
 Muscle Antibodies  >1 publications with TCL1A and Muscle
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