AAH91488.2
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
TEA domain family member 3
NCBI Official Synonym Full Names
TEA domain family member 3
NCBI Official Synonym Symbols
TEF5; TEAD5; TEF-5; DTEF-1; ETFR-1; TEAD-3 [Similar Products]
NCBI Protein Information
transcriptional enhancer factor TEF-5; TEA domain family member 5; transcriptional enhancer factor 5; transcriptional enhancer factor TEF-5 (DTEF-1)
UniProt Protein Name
Transcriptional enhancer factor TEF-5
UniProt Synonym Protein Names
DTEF-1; TEA domain family member 3; TEAD-3
UniProt Synonym Gene Names
UniProt Entry Name
TEAD3_HUMAN
NCBI Summary for TEAD3
This gene product is a member of the transcriptional enhancer factor (TEF) family of transcription factors, which contain the TEA/ATTS DNA-binding domain. It is predominantly expressed in the placenta and is involved in the transactivation of the chorionic somatomammotropin-B gene enhancer. Translation of this protein is initiated at a non-AUG (AUA) start codon. [provided by RefSeq, Jul 2008]
UniProt Comments for TEAD3
TEAD3: Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds to multiple functional elements of the human chorionic somatomammotropin-B gene enhancer.
Protein type: DNA-binding
Chromosomal Location of Human Ortholog: 6p21.2
Cellular Component: nucleoplasm; transcription factor complex
Molecular Function: protein binding; DNA binding; transcription factor activity
Biological Process: regulation of transcription from RNA polymerase II promoter; transcription initiation from RNA polymerase II promoter; gene expression; positive regulation of transcription from RNA polymerase II promoter; female pregnancy
Research Articles on TEAD3
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Products associated with anti-TEAD3 antibody
Pathways associated with anti-TEAD3 antibody
Diseases associated with anti-TEAD3 antibody
Organs/Tissues associated with anti-TEAD3 antibody
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