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anti-TERF1 antibody :: Goat TERF1/PIN2 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS420396
Western Blot (WB)
Unit / Price
0.1 mg  /  $300 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

TERF1/PIN2, Polyclonal Antibody

 Also Known As   

Goat anti-TERF1/PIN2 Antibody

 Product Synonym Names    Goat Anti-TERF1 / TRF1 Antibody; TERF1; PIN2; TRF; TRF1; TRBF1; hTRF1-AS; telomeric repeat binding factor (NIMA-interacting) 1; Telomeric repeat binding factor 1; telomeric repeat binding protein 1; FLJ41416; t-TRF1; TERF1 antibody; PIN2 antibody; TRF antibody; TRF1 antibody; TRBF1 antibody; hTRF1-AS antibody; telomeric repeat binding factor (NIMA-interacting) 1 antibody; Telomeric repeat binding factor 1 antibody; telomeric repeat binding protein 1 antibody; FLJ41416 antibody; t-TRF1 antibody; TERF1 / PIN2
 Product Gene Name   

anti-TERF1 antibody

[Similar Products]
 Product Synonym Gene Name    PIN2 [Similar Products]
 Antibody/Peptide Pairs    TERF1 / PIN2 peptide (MBS425463) is used for blocking the activity of TERF1/PIN2 antibody (MBS420396)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    TMKKLKLISS DSED
 OMIM    600951
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 Clonality    Polyclonal
 Host    Goat
 Species Reactivity    Tested: Human; Expected from sequence similarity: Human, Pig, Cow
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 Purity/Purification    Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
 Form/Format    Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
 Concentration    100ug specific antibody in 200ul (lot specific)
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 Immunogen    Peptide with sequence C-TMKKLKLISSDSED, from the C Terminus of the protein sequence according to NP_003209.2; NP_059523.2.
 Epitope    C Terminus
 Note    This antibody is expected to recognise isoform 1 (NP_059523.2) and isoform 2 (NP_003209.2).
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 Preparation and Storage    Aliquot and store at -20 degree C. Minimize freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of anti-TERF1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-TERF1 antibody   

Peptide ELISA (EIA), Western Blot (WB)

 Application Notes for anti-TERF1 antibody    Peptide ELISA: Antibody detection limit dilution 1: 8000.
Western Blot: Approx 60-65kDa and 45kDa bands seen in HeLa lysate. Recommended for use at 1-3ug/ml.
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 Western Blot (WB) of anti-TERF1 antibody    Staining (2ug/ml) of HeLa lysate (RIPA buffer, 30ug total protein per lane). Primary incubated for 12 hour. Detected by western blot using chemiluminescence.
anti-TERF1 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for TERF1. It may not necessarily be applicable to this product.
 NCBI GI #    189409140
 NCBI GeneID    7013
 NCBI Accession #    NP_003209.2 [Other Products]
 NCBI Related Accession #    NP_059523.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_003218.3 [Other Products]
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 UniProt Secondary Accession #    Q15553; Q8NHT6; Q93029; A7XP29 [Other Products]
 UniProt Related Accession #    P54274 [Other Products]
 Molecular Weight    48,239 Da
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 NCBI Official Full Name    telomeric repeat-binding factor 1 isoform 2
 NCBI Official Synonym Full Names    telomeric repeat binding factor 1
 NCBI Official Symbol    TERF1 [Similar Products]
 NCBI Official Synonym Symbols   
TRF; PIN2; TRF1; TRBF1; t-TRF1; hTRF1-AS
[Similar Products]
 NCBI Protein Information    telomeric repeat-binding factor 1
 UniProt Protein Name    Telomeric repeat-binding factor 1
 UniProt Synonym Protein Names   
NIMA-interacting protein 2; TTAGGG repeat-binding factor 1; Telomeric protein Pin2/TRF1
 Protein Family    Telomeric repeat-binding factor
 UniProt Gene Name    TERF1 [Similar Products]
 UniProt Synonym Gene Names    PIN2; TRBF1; TRF; TRF1 [Similar Products]
 UniProt Entry Name    TERF1_HUMAN
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 NCBI Summary for TERF1    This gene encodes a telomere specific protein which is a component of the telomere nucleoprotein complex. This protein is present at telomeres throughout the cell cycle and functions as an inhibitor of telomerase, acting in cis to limit the elongation of individual chromosome ends. The protein structure contains a C-terminal Myb motif, a dimerization domain near its N-terminus and an acidic N-terminus. Two transcripts of this gene are alternatively spliced products. [provided by RefSeq, Jul 2008]
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 UniProt Comments for TERF1    TRF1: a telomeric repeat binding factor. Binds the telomeric double-stranded TTAGGG repeat and negatively regulates telomere length. Colocalizes with telomeric DNA in interphase and metaphase cells and is located at chromosome ends during metaphase. Involved in the regulation of the mitotic spindle. Expression is tightly regulated during the cell cycle; levels are low in G1 and S phase and increase during G2 phase and mitosis. Two splice variant isoforms have been described.

Protein type: DNA-binding

Chromosomal Location of Human Ortholog: 8q21.11

Cellular Component: chromosome, telomeric region; cytoplasm; nuclear chromosome, telomeric region; nuclear telomere cap complex; nucleolus; nucleoplasm; nucleus; spindle

Molecular Function: DNA bending activity; DNA binding; double-stranded telomeric DNA binding; microtubule binding; protein binding; protein heterodimerization activity; protein homodimerization activity; telomerase activity; telomeric DNA binding; ubiquitin binding

Biological Process: cell division; G2/M transition of mitotic cell cycle; mitosis; mitotic cell cycle spindle assembly checkpoint; negative regulation of DNA replication; negative regulation of telomerase activity; negative regulation of telomere maintenance via semi-conservative replication; negative regulation of telomere maintenance via telomerase; positive regulation of apoptosis; positive regulation of microtubule polymerization; positive regulation of mitosis; positive regulation of mitotic cell cycle; protein homooligomerization; response to drug; telomere capping; telomere clustering; telomere maintenance; telomere maintenance via telomerase; telomeric loop formation
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 Research Articles on TERF1    1. TRF1 links TopoIIalpha and SAC proteins in a pathway that ensures correct telomere replication and mitotic segregation, unveiling how TRF1 protects from telomere fragility and mitotic defects.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-TERF1 antibodyDiseases associated with anti-TERF1 antibody
 Products by Pathway  Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cellular Senescence Pathway antibodies  Cellular Senescence Pathway Diagram
 Cellular Responses To Stress Pathway antibodies  Cellular Responses To Stress Pathway Diagram
 Chromosome Maintenance Pathway antibodies  Chromosome Maintenance Pathway Diagram
 DNA Damage/Telomere Stress Induced Senescence Pathway antibodies  DNA Damage/Telomere Stress Induced Senescence Pathway Diagram
 Meiosis Pathway antibodies  Meiosis Pathway Diagram
 Meiotic Synapsis Pathway antibodies  Meiotic Synapsis Pathway Diagram
 Packaging Of Telomere Ends Pathway antibodies  Packaging Of Telomere Ends Pathway Diagram
 Regulation Of Telomerase Pathway antibodies  Regulation Of Telomerase Pathway Diagram
 Shelterin Complex Pathway antibodies  Shelterin Complex Pathway Diagram
 Disease Name  Pubmed Publications
 Congenital Abnormalities Antibodies  >3 publications with TERF1 and Congenital Abnormalities
 Anemia Antibodies  >3 publications with TERF1 and Anemia
 Cardiovascular Diseases Antibodies  >1 publications with TERF1 and Cardiovascular Diseases
 Fetal Death Antibodies  >1 publications with TERF1 and Fetal Death
 Brain Diseases Antibodies  >1 publications with TERF1 and Brain Diseases
 Hyperplasia Antibodies  >1 publications with TERF1 and Hyperplasia
 Atherosclerosis Antibodies  >1 publications with TERF1 and Atherosclerosis
 Kidney Diseases Antibodies  >1 publications with TERF1 and Kidney Diseases
 Fibrosis Antibodies  >1 publications with TERF1 and Fibrosis
 Nervous System Diseases Antibodies  >1 publications with TERF1 and Nervous System Diseases
Organs/Tissues associated with anti-TERF1 antibody
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >7 publications with TERF1 and Blood
 Bone Antibodies  >6 publications with TERF1 and Bone
 Lung Antibodies  >5 publications with TERF1 and Lung
 Skin Antibodies  >5 publications with TERF1 and Skin
 Embryonic Tissue Antibodies  >4 publications with TERF1 and Embryonic Tissue
 Brain Antibodies  >4 publications with TERF1 and Brain
 Bone Marrow Antibodies  >3 publications with TERF1 and Bone Marrow
 Thyroid Antibodies  >3 publications with TERF1 and Thyroid
 Nerve Antibodies  >2 publications with TERF1 and Nerve
 Eye Antibodies  >2 publications with TERF1 and Eye
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