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anti-TERF1 antibody :: Rabbit anti-Human TERF1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS1496917
Unit / Price
0.05 mL  /  $120 +1 FREE 8GB USB
0.1 mL  /  $160 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

TERF1, Polyclonal Antibody

★Popular Item★
 Also Known As   

TERF1 Antibody

 Product Synonym Names    NIMA-interacting protein 2; TTAGGG repeat-binding factor 1; Telomeric protein Pin2/TRF1; TERF1; PIN2; TRBF1; TRF; TRF1
 Product Gene Name   

anti-TERF1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    600951
 3D Structure    ModBase 3D Structure for P54274
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Purity/Purification    Antigen Affinity Purified
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 Storage Buffer    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
 Conjugate    Non-conjugated
 Immunogen    Recombinant human Telomeric repeat-binding factor 1 protein (260-439aa)
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-1977 / sc-5596 / sc-6165-R
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-TERF1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-TERF1 antibody

   Binds the telomeric double-stranded 5'-TTAGGG-3' repeat and negatively regulates telomere length. Involved in the regulation of the mitotic spindle. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded 5'-TTAGGG-3' repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways.
 Applications Tested/Suitable for anti-TERF1 antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-TERF1 antibody    Recommended dilution: WB:1:200-1000
IHC:1:20-1:200
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 Western Blot (WB) of anti-TERF1 antibody    Western blot
All lanes: TERF1 antibody at 2ug/ml
Lane 1:k562 whole cell lysate
Lane 2:293T whole cell lysate
Lane 3:Jurkat whole cell lysate
Secondary
Goat polyclonal to rabbit at 1/10000 dilution
Predicted band size: 51,49 kDa
Observed band size: 50 kDa

anti-TERF1 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-TERF1 antibody    Immunohistochemistry of paraffin-embedded human skeletal muscle tissue using MBS1496917 at dilution 1:100
anti-TERF1 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for TERF1. It may not necessarily be applicable to this product.
 NCBI GI #    189409140
 NCBI GeneID    7013
 NCBI Accession #    NP_003209.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_003218.3 [Other Products]
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 UniProt Primary Accession #    P54274 [Other Products]
 UniProt Secondary Accession #    Q15553; Q8NHT6; Q93029; A7XP29 [Other Products]
 UniProt Related Accession #    P54274 [Other Products]
 Molecular Weight    48,239 Da
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 NCBI Official Full Name    telomeric repeat-binding factor 1 isoform 2
 NCBI Official Synonym Full Names    telomeric repeat binding factor (NIMA-interacting) 1
 NCBI Official Symbol    TERF1 [Similar Products]
 NCBI Official Synonym Symbols   
TRF; PIN2; TRF1; TRBF1; t-TRF1; hTRF1-AS
[Similar Products]
 NCBI Protein Information    telomeric repeat-binding factor 1
 UniProt Protein Name    Telomeric repeat-binding factor 1
 UniProt Synonym Protein Names   
NIMA-interacting protein 2; TTAGGG repeat-binding factor 1; Telomeric protein Pin2/TRF1
 Protein Family    Telomeric repeat-binding factor
 UniProt Gene Name    TERF1 [Similar Products]
 UniProt Synonym Gene Names    PIN2; TRBF1; TRF; TRF1 [Similar Products]
 UniProt Entry Name    TERF1_HUMAN
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 NCBI Summary for TERF1    This gene encodes a telomere specific protein which is a component of the telomere nucleoprotein complex. This protein is present at telomeres throughout the cell cycle and functions as an inhibitor of telomerase, acting in cis to limit the elongation of individual chromosome ends. The protein structure contains a C-terminal Myb motif, a dimerization domain near its N-terminus and an acidic N-terminus. Two transcripts of this gene are alternatively spliced products. [provided by RefSeq, Jul 2008]
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 UniProt Comments for TERF1    TRF1: a telomeric repeat binding factor. Binds the telomeric double-stranded TTAGGG repeat and negatively regulates telomere length. Colocalizes with telomeric DNA in interphase and metaphase cells and is located at chromosome ends during metaphase. Involved in the regulation of the mitotic spindle. Expression is tightly regulated during the cell cycle; levels are low in G1 and S phase and increase during G2 phase and mitosis. Two splice variant isoforms have been described.

Protein type: DNA-binding

Chromosomal Location of Human Ortholog: 8q21.11

Cellular Component: chromosome, telomeric region; cytoplasm; nuclear chromosome, telomeric region; nuclear telomere cap complex; nucleolus; nucleoplasm; nucleus; spindle

Molecular Function: DNA bending activity; DNA binding; double-stranded telomeric DNA binding; microtubule binding; protein binding; protein heterodimerization activity; protein homodimerization activity; telomerase activity; telomeric DNA binding; ubiquitin binding

Biological Process: cell division; G2/M transition of mitotic cell cycle; mitosis; mitotic cell cycle spindle assembly checkpoint; negative regulation of DNA replication; negative regulation of telomerase activity; negative regulation of telomere maintenance via semi-conservative replication; negative regulation of telomere maintenance via telomerase; positive regulation of apoptosis; positive regulation of microtubule polymerization; positive regulation of mitosis; positive regulation of mitotic cell cycle; protein homooligomerization; response to drug; telomere clustering; telomere maintenance; telomere maintenance via telomerase
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 Research Articles on TERF1    1. Results showed significant interaction between variants at TERF1 and AFAP1L2 loci. Given the key role of TERF1 in telomere biology and its physical interaction with AFAP1L2, these results support a role for telomere dysfunction in melanoma development.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-TERF1 antibodyPathways associated with anti-TERF1 antibody
 Reference Product  PubMed Publications
 TERF2 antibody  >28 publications with TERF1 and TERF2
 POT1 antibody  >12 publications with TERF1 and POT1
 TINF2 antibody  >6 publications with TERF1 and TINF2
 ACD antibody  >5 publications with TERF1 and ACD
 TNKS2 antibody  >5 publications with TERF1 and TNKS2
 TNKS antibody  >5 publications with TERF1 and TNKS
 ATM antibody  >3 publications with TERF1 and ATM
 PINX1 antibody  >2 publications with TERF1 and PINX1
 Products by Pathway  Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cellular Senescence Pathway antibodies  Cellular Senescence Pathway Diagram
 Cellular Responses To Stress Pathway antibodies  Cellular Responses To Stress Pathway Diagram
 Chromosome Maintenance Pathway antibodies  Chromosome Maintenance Pathway Diagram
 DNA Damage/Telomere Stress Induced Senescence Pathway antibodies  DNA Damage/Telomere Stress Induced Senescence Pathway Diagram
 Meiosis Pathway antibodies  Meiosis Pathway Diagram
 Meiotic Synapsis Pathway antibodies  Meiotic Synapsis Pathway Diagram
 Packaging Of Telomere Ends Pathway antibodies  Packaging Of Telomere Ends Pathway Diagram
 Regulation Of Telomerase Pathway antibodies  Regulation Of Telomerase Pathway Diagram
 Shelterin Complex Pathway antibodies  Shelterin Complex Pathway Diagram
Diseases associated with anti-TERF1 antibodyOrgans/Tissues associated with anti-TERF1 antibody
 Disease Name  Pubmed Publications
 Anemia Antibodies  >3 publications with TERF1 and Anemia
 Congenital Abnormalities Antibodies  >3 publications with TERF1 and Congenital Abnormalities
 Lung Diseases Antibodies  >3 publications with TERF1 and Lung Diseases
 Fetal Death Antibodies  >1 publications with TERF1 and Fetal Death
 Cardiovascular Diseases Antibodies  >1 publications with TERF1 and Cardiovascular Diseases
 Hyperplasia Antibodies  >1 publications with TERF1 and Hyperplasia
 Brain Diseases Antibodies  >1 publications with TERF1 and Brain Diseases
 Kidney Diseases Antibodies  >1 publications with TERF1 and Kidney Diseases
 Atherosclerosis Antibodies  >1 publications with TERF1 and Atherosclerosis
 Nervous System Diseases Antibodies  >1 publications with TERF1 and Nervous System Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >7 publications with TERF1 and Blood
 Bone Antibodies  >6 publications with TERF1 and Bone
 Skin Antibodies  >5 publications with TERF1 and Skin
 Lung Antibodies  >4 publications with TERF1 and Lung
 Embryonic Tissue Antibodies  >4 publications with TERF1 and Embryonic Tissue
 Brain Antibodies  >4 publications with TERF1 and Brain
 Bone Marrow Antibodies  >3 publications with TERF1 and Bone Marrow
 Thyroid Antibodies  >3 publications with TERF1 and Thyroid
 Nerve Antibodies  >2 publications with TERF1 and Nerve
 Eye Antibodies  >2 publications with TERF1 and Eye
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