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anti-TERF2 antibody :: Rabbit anti-Human, Mouse TERF2 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS7044966
Unit / Price
0.05 mg  /  $160 +1 FREE 8GB USB
0.1 mg  /  $235 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

TERF2, Polyclonal Antibody

★Popular Item★
 Also Known As   

TERF2 Antibody

 Product Synonym Names    Telomeric repeat-binding factor 2; TTAGGG repeat-binding factor 2; Telomeric DNA-binding protein; TERF2; TRBF2; TRF2
 Product Gene Name   

anti-TERF2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    602027
 3D Structure    ModBase 3D Structure for Q15554
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse
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 Purity/Purification    >95%, Protein G purified
 Form/Format    Liquid
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 Species    Human
 Immunogen    Recombinant human Telomeric repeat-binding factor 2 protein
 Conjugate    Non-conjugated
 Buffer    Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-8528 / sc-32104 / sc-32106 / sc-9143
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-TERF2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-TERF2 antibody

   Binds the telomeric double-stranded 5'-TTAGGG-3' repeat and plays a central role in telomere maintenance and protection against end-to-end fusion of chromosomes. In addition to its telomeric DNA-binding role, required to recruit a number of factors and enzymes required for telomere protection, including the shelterin complex, TERF2IP/RAP1 and DCLRE1B/Apollo. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded 5'-TTAGGG-3' repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Together with DCLRE1B/Apollo, plays a key role in telomeric loop (T loop) formation by generating 3' single-stranded overhang at the leading end telomeres: T loops have been proposed to protect chromosome ends from degradation and repair. Required both to recruit DCLRE1B/Apollo to telomeres and activate the exonuclease activity of DCLRE1B/Apollo. Preferentially binds to positive supercoiled DNA. Together with DCLRE1B/Apollo, required to control the amount of DNA topoisomerase (TOP1, TOP2A and TOP2B) needed for telomere replication during fork passage and prevent aberrant telomere topology. Recruits TERF2IP/RAP1 to telomeres, thereby participating in to repressing homology-directed repair (HDR), which can affect telomere length.
 Applications Tested/Suitable for anti-TERF2 antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

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 Western Blot (WB) of anti-TERF2 antibody    Western blot
All lanes: TERF2 antibody at 14 ug/ml
Lane 1: Mouse thymus tissue
Lane 2: MCF7 whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 60,33 kDa
Observed band size: 60,31 kDa

anti-TERF2 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-TERF2 antibody    Immunohistochemistry of paraffin-embedded human tonsil tissue using MBS7044966 at dilution of 1:100
anti-TERF2 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-TERF2 antibody    Immunofluorescent analysis of Hela cells using MBS7044966 at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
anti-TERF2 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for TERF2. It may not necessarily be applicable to this product.
 NCBI GI #    429535832
 NCBI GeneID    7014
 NCBI Accession #    NP_005643.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_005652.4 [Other Products]
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 UniProt Primary Accession #    Q15554 [Other Products]
 UniProt Related Accession #    Q15554 [Other Products]
 Molecular Weight    32,298 Da
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 NCBI Official Full Name    telomeric repeat-binding factor 2
 NCBI Official Synonym Full Names    telomeric repeat binding factor 2
 NCBI Official Symbol    TERF2 [Similar Products]
 NCBI Official Synonym Symbols   
TRF2; TRBF2
[Similar Products]
 NCBI Protein Information    telomeric repeat-binding factor 2
 UniProt Protein Name    Telomeric repeat-binding factor 2
 UniProt Synonym Protein Names   
TTAGGG repeat-binding factor 2; Telomeric DNA-binding protein
 Protein Family    Telomeric repeat-binding factor
 UniProt Gene Name    TERF2 [Similar Products]
 UniProt Synonym Gene Names    TRBF2; TRF2 [Similar Products]
 UniProt Entry Name    TERF2_HUMAN
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 NCBI Summary for TERF2    This gene encodes a telomere specific protein, TERF2, which is a component of the telomere nucleoprotein complex. This protein is present at telomeres in metaphase of the cell cycle, is a second negative regulator of telomere length and plays a key role in the protective activity of telomeres. While having similar telomere binding activity and domain organization, TERF2 differs from TERF1 in that its N terminus is basic rather than acidic. [provided by RefSeq, Jul 2008]
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 UniProt Comments for TERF2    TRF2: Binds the telomeric double-stranded 5'-TTAGGG-3' repeat and plays a central role in telomere maintenance and protection against end-to-end fusion of chromosomes. In addition to its telomeric DNA-binding role, required to recruit a number of factors and enzymes required for telomere protection, including the shelterin complex, TERF2IP/RAP1 and DCLRE1B/Apollo. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded 5'-TTAGGG-3' repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Together with DCLRE1B/Apollo, plays a key role in telomeric loop (T loop) formation by generating 3' single- stranded overhang at the leading end telomeres: T loops have been proposed to protect chromosome ends from degradation and repair. Required both to recruit DCLRE1B/Apollo to telomeres and activate the exonuclease activity of DCLRE1B/Apollo. Preferentially binds to positive supercoiled DNA. Together with DCLRE1B/Apollo, required to control the amount of DNA topoisomerase (TOP1, TOP2A and TOP2B) needed for telomere replication during fork passage and prevent aberrant telomere topology. Recruits TERF2IP/RAP1 to telomeres, thereby participating in to repressing homology- directed repair (HDR), which can affect telomere length. Homodimer. Component of the shelterin complex (telosome) composed of TERF1, TERF2, TINF2, TERF2IP/RAP1, ACD and POT1. Interacts with TERF2IP. Interacts with NBN. Interacts with SLX4/BTBD12. Interacts with DCLRE1B/Apollo and TERF2IP/RAP1; the interaction is direct. Ubiquitous. Highly expressed in spleen, thymus, prostate, uterus, testis, small intestine, colon and peripheral blood leukocytes. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: DNA repair, damage; DNA-binding

Chromosomal Location of Human Ortholog: 16q22.1

Cellular Component: chromosome, telomeric region; cytoplasm; Golgi apparatus; Mre11 complex; nuclear chromosome, telomeric region; nuclear telomere cap complex; nucleoplasm; nucleus

Molecular Function: double-stranded telomeric DNA binding; protein binding; protein C-terminus binding; protein homodimerization activity; telomerase activity; telomeric DNA binding

Biological Process: negative regulation of telomere maintenance; negative regulation of telomere maintenance via recombination; positive regulation of nitric-oxide synthase activity; positive regulation of telomere maintenance; protection from non-homologous end joining at telomere; regulation of telomere maintenance; regulation of telomere maintenance via telomerase; telomere capping; telomere maintenance; telomere maintenance via telomerase; telomeric loop formation
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 Research Articles on TERF2    1. These observations suggest that TRF2 is a good candidate for the attachment of telomeres to the nuclear envelope in somatic cells
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-TERF2 antibodyPathways associated with anti-TERF2 antibody
 Reference Product  PubMed Publications
 POT1 antibody  >32 publications with TERF2 and POT1
 ATM antibody  >27 publications with TERF2 and ATM
 TERF2IP antibody  >22 publications with TERF2 and TERF2IP
 TINF2 antibody  >13 publications with TERF2 and TINF2
 WRN antibody  >6 publications with TERF2 and WRN
 DCLRE1B antibody  >5 publications with TERF2 and DCLRE1B
 BLM antibody  >3 publications with TERF2 and BLM
 RAD50 antibody  >3 publications with TERF2 and RAD50
 NBN antibody  >2 publications with TERF2 and NBN
 MRE11A antibody  >2 publications with TERF2 and MRE11A
 Products by Pathway  Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cellular Senescence Pathway antibodies  Cellular Senescence Pathway Diagram
 Cellular Responses To Stress Pathway antibodies  Cellular Responses To Stress Pathway Diagram
 Chromosome Maintenance Pathway antibodies  Chromosome Maintenance Pathway Diagram
 DNA Damage/Telomere Stress Induced Senescence Pathway antibodies  DNA Damage/Telomere Stress Induced Senescence Pathway Diagram
 Meiosis Pathway antibodies  Meiosis Pathway Diagram
 Meiotic Synapsis Pathway antibodies  Meiotic Synapsis Pathway Diagram
 Packaging Of Telomere Ends Pathway antibodies  Packaging Of Telomere Ends Pathway Diagram
 Regulation Of Telomerase Pathway antibodies  Regulation Of Telomerase Pathway Diagram
 Shelterin Complex Pathway antibodies  Shelterin Complex Pathway Diagram
Diseases associated with anti-TERF2 antibodyOrgans/Tissues associated with anti-TERF2 antibody
 Disease Name  Pubmed Publications
 Breast Neoplasms Antibodies  >9 publications with TERF2 and Breast Neoplasms
 Death Antibodies  >7 publications with TERF2 and Death
 Neoplasms, Experimental Antibodies  >7 publications with TERF2 and Neoplasms, Experimental
 Nervous System Diseases Antibodies  >6 publications with TERF2 and Nervous System Diseases
 Lung Neoplasms Antibodies  >6 publications with TERF2 and Lung Neoplasms
 Neoplasm Metastasis Antibodies  >5 publications with TERF2 and Neoplasm Metastasis
 Carcinoma, Squamous Cell Antibodies  >4 publications with TERF2 and Carcinoma, Squamous Cell
 Congenital Abnormalities Antibodies  >4 publications with TERF2 and Congenital Abnormalities
 Cell Transformation, Neoplastic Antibodies  >4 publications with TERF2 and Cell Transformation, Neoplastic
 Bone Marrow Diseases Antibodies  >4 publications with TERF2 and Bone Marrow Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >15 publications with TERF2 and Blood
 Vascular Antibodies  >8 publications with TERF2 and Vascular
 Lung Antibodies  >8 publications with TERF2 and Lung
 Bone Antibodies  >7 publications with TERF2 and Bone
 Brain Antibodies  >7 publications with TERF2 and Brain
 Muscle Antibodies  >5 publications with TERF2 and Muscle
 Skin Antibodies  >4 publications with TERF2 and Skin
 Prostate Antibodies  >4 publications with TERF2 and Prostate
 Heart Antibodies  >3 publications with TERF2 and Heart
 Lymph Antibodies  >3 publications with TERF2 and Lymph
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