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anti-TET1 antibody :: Rabbit TET1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS8502263
Testing Data
Unit / Price
0.1 mL  /  $310 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

TET1, Polyclonal Antibody

★Popular Item★
 Also Known As   

TET1 Polyclonal Antibody

 Product Synonym Names    LCX; CXXC6; bA119F7.1; TET1
 Product Gene Name   

anti-TET1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    607790
 3D Structure    ModBase 3D Structure for Q8NFU7
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Affinity purification
 Concentration    100ug/ul (lot specific)
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 Immunogen    Recombinant protein of human TET1
 Species    Rabbit
 Buffer    PBS with 0.02% sodium azide, 50% glycerol, pH 7.3
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 Preparation and Storage    Store at -20 degree C or -80 degree C. Avoid freeze / thaw cycles.
 Other Notes    Small volumes of anti-TET1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-TET1 antibody

   Background: TET1 (tet oncogene 1), also known as LCX or CXXC6, is a 2,136 amino acid protein that localizes to the nucleus and contains one CXXC-type zinc finger. Expressed in adult ovary, thymus and skeletal muscle and also present in fetal lung, heart and brain, TET1 is thought to play a role in the development of fetal organs and may also be involvement in the pathoegenesis and metastasis of acute myeloid leukemia (AML). The gene encoding TET1 maps to human chromosome 10, which houses over 1,200 genes and comprises nearly 4.5% of the human genome. Defects in some of the genes that map to chromosome 10 are associated with Charcot-Marie Tooth disease, Jackson-Weiss syndrome, Usher syndrome, nonsyndromatic deafness, Wolman's syndrome, Cowden syndrome, multiple endocrine neoplasia type 2 and porphyria.
 Product Categories/Family for anti-TET1 antibody    Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody
 Applications Tested/Suitable for anti-TET1 antibody   

Western Blot (WB), Immunoprecipitation (IP)

 Application Notes for anti-TET1 antibody    WB: 1:500 - 1:2000, IP: 1:20 - 1:100
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 Testing Data of anti-TET1 antibody    Western blot analysis of extracts of A431 celllines, using TET1 antibody.
anti-TET1 antibody Testing Data image
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NCBI/Uniprot data below describe general gene information for TET1. It may not necessarily be applicable to this product.
 NCBI GI #    156139122
 NCBI GeneID    80312
 NCBI Accession #    NP_085128.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_030625.2 [Other Products]
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 UniProt Primary Accession #    Q8NFU7 [Other Products]
 UniProt Secondary Accession #    Q5VUP7; Q7Z6B6; Q8TCR1; Q9C0I7 [Other Products]
 UniProt Related Accession #    Q8NFU7 [Other Products]
 Molecular Weight    235kDa
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 NCBI Official Full Name    methylcytosine dioxygenase TET1
 NCBI Official Synonym Full Names    tet methylcytosine dioxygenase 1
 NCBI Official Symbol    TET1 [Similar Products]
 NCBI Official Synonym Symbols   
LCX; CXXC6; bA119F7.1
[Similar Products]
 NCBI Protein Information    methylcytosine dioxygenase TET1; CXXC finger 6; tet oncogene 1; CXXC zinc finger 6; TET1 splice variant VP_DE4; ten-eleven translocation-1; TET1 splice variant VP_DE456; CXXC-type zinc finger protein 6; ten-eleven translocation 1 gene protein; leukemia-associated protein with a CXXC domain
 UniProt Protein Name    Methylcytosine dioxygenase TET1
 UniProt Synonym Protein Names   
CXXC-type zinc finger protein 6; Leukemia-associated protein with a CXXC domain; Ten-eleven translocation 1 gene protein
 Protein Family    Methylcytosine dioxygenase
 UniProt Gene Name    TET1 [Similar Products]
 UniProt Synonym Gene Names    CXXC6; KIAA1676; LCX [Similar Products]
 UniProt Entry Name    TET1_HUMAN
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 UniProt Comments for TET1    TET1: Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5- hydroxymethylcytosine (5hmC). Might initiate a process leading to cytosine demethylation through deamination into 5- hydroxymethyluracil (5hmU) and subsequent replacement by unmethylated cytosine by the base excision repair system. Methylation at the C5 position of cytosine bases is an epigenetic modification of the mammalian genome which plays an important role in transcriptional regulation. Preferentially binds to CpG-rich sequences at promoters of both transcriptionally active and polycomb-repressed genes. By controlling the levels of 5mC and 5hmC at gene promoters, it may regulate the gene expression silencing induced by cytosine methylation. May have a dual function by also repressing the expression of a subset of genes through recruitment of transcriptional repressors to promoters. Involved in the balance between pluripotency and lineage commitment of cells it plays a role in embryonic stem cells maintenance and inner cell mass cell specification. A chromosomal aberration involving TET1 may be a cause of acute leukemias. Translocation t(10;11)(q22;q23) with MLL. This is a rare chromosomal translocation 5' MLL-TET1 3'. Belongs to the TET family.

Protein type: Oxidoreductase; DNA-binding; EC 1.14.11.n2

Chromosomal Location of Human Ortholog: 10q21

Cellular Component: nucleus

Molecular Function: structure-specific DNA binding; zinc ion binding; iron ion binding

Biological Process: protein amino acid O-linked glycosylation; inner cell mass cell differentiation; transcription, DNA-dependent; stem cell maintenance; gene expression; positive regulation of transcription from RNA polymerase II promoter; chromatin modification; regulation of gene expression, epigenetic
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 Research Articles on TET1    1. the results identify TET1 as a maintenance DNA demethylase that does not purposely decrease methylation levels, but specifically prevents aberrant methylation spreading into unmethylated CpG islands in differentiated cells.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-TET1 antibodyPathways associated with anti-TET1 antibody
 Reference Product  PubMed Publications
 DNMT3A antibody  >14 publications with TET1 and DNMT3A
 DNMT3B antibody  >14 publications with TET1 and DNMT3B
 NANOG antibody  >10 publications with TET1 and NANOG
 SIN3A antibody  >4 publications with TET1 and SIN3A
 MBD3 antibody  >1 publications with TET1 and MBD3
 Products by Pathway  Pathway Diagram
 Epigenetic Regulation Of Gene Expression Pathway antibodies  Epigenetic Regulation Of Gene Expression Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 TET1,2,3 And TDG Demethylate DNA Pathway antibodies  TET1,2,3 And TDG Demethylate DNA Pathway Diagram
Diseases associated with anti-TET1 antibodyOrgans/Tissues associated with anti-TET1 antibody
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >17 publications with TET1 and Nervous System Diseases
 Brain Diseases Antibodies  >12 publications with TET1 and Brain Diseases
 Breast Neoplasms Antibodies  >4 publications with TET1 and Breast Neoplasms
 Neoplasm Metastasis Antibodies  >3 publications with TET1 and Neoplasm Metastasis
 Inflammation Antibodies  >3 publications with TET1 and Inflammation
 Lung Neoplasms Antibodies  >2 publications with TET1 and Lung Neoplasms
 Liver Neoplasms Antibodies  >2 publications with TET1 and Liver Neoplasms
 Carcinoma, Hepatocellular Antibodies  >2 publications with TET1 and Carcinoma, Hepatocellular
 Muscular Diseases Antibodies  >2 publications with TET1 and Muscular Diseases
 Congenital Abnormalities Antibodies  >2 publications with TET1 and Congenital Abnormalities
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >30 publications with TET1 and Brain
 Embryonic Tissue Antibodies  >14 publications with TET1 and Embryonic Tissue
 Bone Antibodies  >5 publications with TET1 and Bone
 Lung Antibodies  >5 publications with TET1 and Lung
 Testis Antibodies  >4 publications with TET1 and Testis
 Prostate Antibodies  >4 publications with TET1 and Prostate
 Thymus Antibodies  >3 publications with TET1 and Thymus
 Eye Antibodies  >3 publications with TET1 and Eye
 Lymph Node Antibodies  >3 publications with TET1 and Lymph Node
 Heart Antibodies  >3 publications with TET1 and Heart
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