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anti-TET2 antibody :: Goat TET2 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS421699
Immunohistochemistry (IHC)
Unit / Price
0.1 mg  /  $300 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

TET2, Polyclonal Antibody

★Popular Item★
 Also Known As   

Goat anti-TET2 Antibody

 Product Synonym Names    TET2; tet oncogene family member 2; FLJ20032; KIAA1546; MGC125715; OTTHUMP00000161869; TET2 antibody; tet oncogene family member 2 antibody; FLJ20032 antibody; KIAA1546 antibody; MGC125715 antibody; OTTHUMP00000161869 antibody
 Product Gene Name   

anti-TET2 antibody

[Similar Products]
 Antibody/Peptide Pairs    TET2 peptide (MBS426378) is used for blocking the activity of TET2 antibody (MBS421699)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    PHPQSNNDQQ REGSF
 OMIM    263300
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 Clonality    Polyclonal
 Host    Goat
 Species Reactivity    Tested: Human; Expected from sequence similarity: Human, Mouse, Dog
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 Purity/Purification    Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
 Form/Format    Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
 Concentration    100ug specific antibody in 200ul (lot specific)
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 Immunogen    Peptide with sequence C-PHPQSNNDQQREGSF, from the internal region of the protein sequence according to NP_001120680.1; NP_060098.3.
 Epitope    Internal region
 Note    This antibody is expected to recognize both reported isoforms (NP_001120680.1; NP_060098.3).
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 Preparation and Storage    Aliquot and store at -20 degree C. Minimize freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of anti-TET2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-TET2 antibody   

Peptide ELISA (EIA), Immunohistochemistry (IHC)

 Application Notes for anti-TET2 antibody    Peptide ELISA: Antibody detection limit dilution 1: 16000.
Immunohistochemistry: In paraffin embedded Human Spleen shows nuclear staining in select splenocytes. This antibody has also been used successfully on Human Brain sections: Orr et al, PLoS One.2012;7(7): e41036.2012 Jul 19. PMID: 22829908. Recommended concentration, 2-6ug/ml.
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 Immunohistochemistry (IHC) of anti-TET2 antibody    (4ug/ml) staining of paraffin embedded Human Spleen. Steamed antigen retrieval with citrate buffer pH 6, HRP-staining.
anti-TET2 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for TET2. It may not necessarily be applicable to this product.
 NCBI GI #    187761317
 NCBI GeneID    54790
 NCBI Accession #    NP_001120680.1 [Other Products]
 NCBI Related Accession #    NP_060098.3 [Other Products]
 NCBI GenBank Nucleotide #    NM_001127208.2 [Other Products]
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 UniProt Secondary Accession #    Q2TB88; Q3LIB8; Q96JX5; Q9HCM6; Q9NXW0; B5MDU0 [Other Products]
 UniProt Related Accession #    Q6N021 [Other Products]
 Molecular Weight    133,481 Da
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 NCBI Official Full Name    methylcytosine dioxygenase TET2 isoform a
 NCBI Official Synonym Full Names    tet methylcytosine dioxygenase 2
 NCBI Official Symbol    TET2 [Similar Products]
 NCBI Official Synonym Symbols   
MDS; KIAA1546
[Similar Products]
 NCBI Protein Information    methylcytosine dioxygenase TET2
 UniProt Protein Name    Methylcytosine dioxygenase TET2
 Protein Family    Tetraspanin
 UniProt Gene Name    TET2 [Similar Products]
 UniProt Synonym Gene Names    KIAA1546 [Similar Products]
 UniProt Entry Name    TET2_HUMAN
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 NCBI Summary for TET2    The protein encoded by this gene is a methylcytosine dioxygenase that catalyzes the conversion of methylcytosine to 5-hydroxymethylcytosine. The encoded protein is involved in myelopoiesis, and defects in this gene have been associated with several myeloproliferative disorders. Two variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2011]
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 UniProt Comments for TET2    TET2: Catalyzes the conversion of methylcytosine (5mC) to 5- hydroxymethylcytosine (hmC). Plays an important role in myelopoiesis. The clear function of 5-hydroxymethylcytosine (hmC) is still unclear but it may influence chromatin structure and recruit specific factors or may constitute an intermediate component in cytosine demethylation. TET2 is frequently mutated in myeloproliferative disorders (MPD). These constitute a heterogeneous group of disorders, also known as myeloproliferative diseases or myeloproliferative neoplasms (MPN), characterized by cellular proliferation of one or more hematologic cell lines in the peripheral blood, distinct from acute leukemia. Included diseases are: essential thrombocythemia, polycythemia vera, primary myelofibrosis (chronic idiopathic myelofibrosis). Bone marrow samples from patients display uniformly low levels of hmC in genomic DNA compared to bone marrow samples from healthy controls as well as hypomethylation relative to controls at the majority of differentially methylated CpG sites. Defects in TET2 are a cause of polycythemia vera (PV). A myeloproliferative disorder characterized by abnormal proliferation of all hematopoietic bone marrow elements, erythroid hyperplasia, an absolute increase in total blood volume, but also by myeloid leukocytosis, thrombocytosis and splenomegaly. TET2 is frequently mutated in systemic mastocytosis; also known as systemic mast cell disease. A condition with features in common with myeloproliferative diseases. It is a clonal disorder of the mast cell and its precursor cells. The clinical symptoms and signs of systemic mastocytosis are due to accumulation of clonally derived mast cells in different tissues, including bone marrow, skin, the gastrointestinal tract, the liver, and the spleen. Defects in TET2 are a cause of myelodysplastic syndrome (MDS). A heterogeneous group of closely related clonal hematopoietic disorders. All are characterized by a hypercellular or hypocellular bone marrow with impaired morphology and maturation, dysplasia of the myeloid, megakaryocytic and/or erythroid lineages, and peripheral blood cytopenias resulting from ineffective blood cell production. Included diseases are: refractory anemia (RA), refractory anemia with ringed sideroblasts (RARS), refractory anemia with excess blasts (RAEB), refractory cytopenia with multilineage dysplasia and ringed sideroblasts (RCMD-RS). Chronic myelomonocytic leukemia (CMML) is a myelodysplastic/myeloproliferative disease. Myelodysplastic syndromes are considered a premalignant condition in a subgroup of patients that often progresses to acute myeloid leukemia (AML). Bone marrow samples from patients display uniformly low levels of hmC in genomic DNA compared to bone marrow samples from healthy controls as well as hypomethylation relative to controls at the majority of differentially methylated CpG sites. Belongs to the TET family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Oxidoreductase; Tumor suppressor; EC 1.14.11.n2

Chromosomal Location of Human Ortholog: 4q24

Molecular Function: DNA binding; ferrous iron binding; protein binding; zinc ion binding

Biological Process: 5-methylcytosine catabolic process; cell cycle; cytosine metabolic process; hemoglobin metabolic process; kidney development; myeloid cell differentiation; myeloid progenitor cell differentiation; positive regulation of transcription from RNA polymerase II promoter; post-embryonic development; protein amino acid O-linked glycosylation; response to organic cyclic substance; spleen development

Disease: Myelodysplastic Syndrome
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 Research Articles on TET2    1. Mutation in TET2 or TP53 predicts poor survival in patients with myelodysplastic syndrome receiving hypomethylating treatment or stem cell transplantation.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-TET2 antibodyPathways associated with anti-TET2 antibody
 Reference Product  PubMed Publications
 ASXL1 antibody  >212 publications with TET2 and ASXL1
 IDH1 antibody  >175 publications with TET2 and IDH1
 JAK2 antibody  >148 publications with TET2 and JAK2
 IDH2 antibody  >104 publications with TET2 and IDH2
 RUNX1 antibody  >93 publications with TET2 and RUNX1
 CD34 antibody  >23 publications with TET2 and CD34
 OGT antibody  >9 publications with TET2 and OGT
 PDGFRB antibody  >3 publications with TET2 and PDGFRB
 RARS antibody  >3 publications with TET2 and RARS
 Products by Pathway  Pathway Diagram
 Epigenetic Regulation Of Gene Expression Pathway antibodies  Epigenetic Regulation Of Gene Expression Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 TET1,2,3 And TDG Demethylate DNA Pathway antibodies  TET1,2,3 And TDG Demethylate DNA Pathway Diagram
Diseases associated with anti-TET2 antibodyOrgans/Tissues associated with anti-TET2 antibody
 Disease Name  Pubmed Publications
 Myelodysplastic Syndromes Antibodies  >141 publications with TET2 and Myelodysplastic Syndromes
 Carcinoma Antibodies  >19 publications with TET2 and Carcinoma
 Lymphoma, T-Cell, Peripheral Antibodies  >17 publications with TET2 and Lymphoma, T-Cell, Peripheral
 Cardiovascular Diseases Antibodies  >15 publications with TET2 and Cardiovascular Diseases
 Skin Diseases Antibodies  >13 publications with TET2 and Skin Diseases
 Breast Neoplasms Antibodies  >9 publications with TET2 and Breast Neoplasms
 Neoplasms, Experimental Antibodies  >8 publications with TET2 and Neoplasms, Experimental
 Abnormalities, Multiple Antibodies  >8 publications with TET2 and Abnormalities, Multiple
 Fibrosis Antibodies  >7 publications with TET2 and Fibrosis
 Inflammation Antibodies  >7 publications with TET2 and Inflammation
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >161 publications with TET2 and Blood
 Bone Marrow Antibodies  >88 publications with TET2 and Bone Marrow
 Brain Antibodies  >32 publications with TET2 and Brain
 Prostate Antibodies  >14 publications with TET2 and Prostate
 Muscle Antibodies  >11 publications with TET2 and Muscle
 Lung Antibodies  >8 publications with TET2 and Lung
 Spleen Antibodies  >5 publications with TET2 and Spleen
 Ascites Antibodies  >2 publications with TET2 and Ascites
 Placenta Antibodies  >2 publications with TET2 and Placenta
 Eye Antibodies  >1 publications with TET2 and Eye
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