NP_071761.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
45,349 Da
NCBI Official Full Name
dimethyladenosine transferase 2, mitochondrial
NCBI Official Synonym Full Names
transcription factor B2, mitochondrial
NCBI Official Synonym Symbols
NCBI Protein Information
dimethyladenosine transferase 2, mitochondrial
UniProt Protein Name
Dimethyladenosine transferase 2, mitochondrial
UniProt Synonym Protein Names
Hepatitis C virus NS5A-transactivated protein 5; HCV NS5A-transactivated protein 5; Mitochondrial 12S rRNA dimethylase 2; Mitochondrial transcription factor B2; h-mtTFB; h-mtTFB2; hTFB2M; mtTFB2; S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase 2
UniProt Synonym Gene Names
NS5ATP5; HCV NS5A-transactivated protein 5; h-mtTFB; h-mtTFB2; hTFB2M; mtTFB2 [Similar Products]
UniProt Entry Name
TFB2M_HUMAN
UniProt Comments for TFB2M
TFB2M: S-adenosyl-L-methionine-dependent methyltransferase which specifically dimethylates mitochondrial 12S rRNA at the conserved stem loop. Also required for basal transcription of mitochondrial DNA, probably via its interaction with POLRMT and TFAM. Stimulates transcription independently of the methyltransferase activity. Compared to TFB1M, it activates transcription of mitochondrial DNA more efficiently, while it has less methyltransferase activity. Belongs to the methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. KsgA subfamily.
Protein type: EC 2.1.1.-; Methyltransferase; Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 1q44
Cellular Component: cell junction; mitochondrial matrix; mitochondrion
Molecular Function: rRNA (adenine-N6,N6-)-dimethyltransferase activity; transcription cofactor activity
Biological Process: mitochondrion organization and biogenesis; positive regulation of transcription, DNA-dependent; transcription from mitochondrial promoter; transcription initiation from mitochondrial promoter
Research Articles on TFB2M
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Products associated with anti-TFB2M antibody
Pathways associated with anti-TFB2M antibody
Diseases associated with anti-TFB2M antibody
Organs/Tissues associated with anti-TFB2M antibody
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