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anti-TFDP1 antibody :: Rabbit TFDP1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS820265
Unit / Price
0.03 mL  /  $155 +1 FREE 8GB USB
0.1 mL  /  $220 +1 FREE 8GB USB
0.2 mL  /  $295 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

TFDP1, Polyclonal Antibody

★Popular Item★
 Also Known As   

Anti-TFDP1 Antibody

 Product Synonym Names    DP1; Transcription factor Dp-1; DRTF1-polypeptide 1; DRTF1; E2F dimerization partner 1
 Product Gene Name   

anti-TFDP1 antibody

[Similar Products]
 Antibody/Peptide Pairs    TFDP1 peptide (MBS823724) is used for blocking the activity of TFDP1 antibody (MBS820265)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    189902
 3D Structure    ModBase 3D Structure for Q14186
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Specificity    Recognizes endogenous levels of TFDP1 protein.
 Purity/Purification    The antibody was purified by immunogen affinity chromatography.
 Form/Format    Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
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 Immunogen    KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human TFDP1. The exact sequence is proprietary.
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C for one year. Avoid freeze/thaw cycles.
 Other Notes    Small volumes of anti-TFDP1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-TFDP1 antibody

   Rabbit polyclonal antibody to TFDP1
 Applications Tested/Suitable for anti-TFDP1 antibody   

Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

 Application Notes for anti-TFDP1 antibody    WB (1/500 - 1/1000), IH (1/100 - 1/200), IF/ICC (1/100 - 1/500)
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 Western Blot (WB) of anti-TFDP1 antibody    anti-TFDP1 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-TFDP1 antibody    Immunohistochemical analysis of TFDP1 staining in human tonsil formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.
anti-TFDP1 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunofluorescence/Immunocytochemistry (IF/ICC) of anti-TFDP1 antibody    Immunofluorescent analysis of TFDP1 staining in A431 cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 degree C in a humidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark. DAPI was used to stain the cell nuclei (blue).
anti-TFDP1 antibody Immunofluorescence/Immunocytochemistry (IF/ICC) (ICC) image
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NCBI/Uniprot data below describe general gene information for TFDP1. It may not necessarily be applicable to this product.
 NCBI GI #    6005900
 NCBI GeneID    7027
 NCBI Accession #    NP_009042.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_007111.4 [Other Products]
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 UniProt Primary Accession #    Q14186 [Other Products]
 UniProt Secondary Accession #    Q5JSB4; Q8IZL5; B4DLQ9 [Other Products]
 UniProt Related Accession #    Q14186 [Other Products]
 Molecular Weight    34,921 Da
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 NCBI Official Full Name    transcription factor Dp-1
 NCBI Official Synonym Full Names    transcription factor Dp-1
 NCBI Official Symbol    TFDP1 [Similar Products]
 NCBI Official Synonym Symbols   
DP1; Dp-1; DRTF1
[Similar Products]
 NCBI Protein Information    transcription factor Dp-1; DRTF1-polypeptide 1; E2F dimerization partner 1; E2F-related transcription factor
 UniProt Protein Name    Transcription factor Dp-1
 UniProt Synonym Protein Names   
DRTF1-polypeptide 1; DRTF1; E2F dimerization partner 1
 Protein Family    Transcription factor
 UniProt Gene Name    TFDP1 [Similar Products]
 UniProt Synonym Gene Names    DP1; DRTF1 [Similar Products]
 UniProt Entry Name    TFDP1_HUMAN
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 NCBI Summary for TFDP1    This gene encodes a member of a family of transcription factors that heterodimerize with E2F proteins to enhance their DNA-binding activity and promote transcription from E2F target genes. The encoded protein functions as part of this complex to control the transcriptional activity of numerous genes involved in cell cycle progression from G1 to S phase. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 1, 15, and X.[provided by RefSeq, Jan 2009]
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 UniProt Comments for TFDP1    TFDP1: Can stimulate E2F-dependent transcription. Binds DNA cooperatively with E2F family members through the E2 recognition site, 5'-TTTC[CG]CGC-3', found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DP2/E2F complex functions in the control of cell-cycle progression from G1 to S phase. The E2F1/DP complex appears to mediate both cell proliferation and apoptosis. Belongs to the E2F/DP family.

Protein type: DNA-binding; Transcription, coactivator/corepressor

Chromosomal Location of Human Ortholog: 13q34

Cellular Component: nucleoplasm; transcription factor complex

Molecular Function: protein domain specific binding; protein binding; DNA binding; transcription coactivator activity; transcription factor activity; transcription factor binding

Biological Process: regulation of transcription from RNA polymerase II promoter; transcription initiation from RNA polymerase II promoter; cell proliferation; epidermis development; Notch signaling pathway; transcription, DNA-dependent; apoptosis; transforming growth factor beta receptor signaling pathway; gene expression; positive regulation of transcription from RNA polymerase II promoter; mitotic cell cycle; anoikis; G1/S transition of mitotic cell cycle
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 Research Articles on TFDP1    1. somatic mutations in DP-1 uncouple normal control of the E2F pathway, and thus define a new mechanism that could contribute to aberrant proliferation in tumor cells
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-TFDP1 antibodyPathways associated with anti-TFDP1 antibody
 Reference Product  PubMed Publications
 E2F1 antibody  >92 publications with TFDP1 and E2F1
 E2F4 antibody  >33 publications with TFDP1 and E2F4
 E2F3 antibody  >15 publications with TFDP1 and E2F3
 E2F5 antibody  >14 publications with TFDP1 and E2F5
 E2F2 antibody  >13 publications with TFDP1 and E2F2
 RBL1 antibody  >11 publications with TFDP1 and RBL1
 E2F6 antibody  >5 publications with TFDP1 and E2F6
 Products by Pathway  Pathway Diagram
 Activation Of BH3-only Proteins Pathway antibodies  Activation Of BH3-only Proteins Pathway Diagram
 Activation Of NOXA And Translocation To Mitochondria Pathway antibodies  Activation Of NOXA And Translocation To Mitochondria Pathway Diagram
 Activation Of PUMA And Translocation To Mitochondria Pathway antibodies  Activation Of PUMA And Translocation To Mitochondria Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle, Mitotic Pathway antibodies  Cell Cycle, Mitotic Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cellular Senescence Pathway antibodies  Cellular Senescence Pathway Diagram
Diseases associated with anti-TFDP1 antibodyOrgans/Tissues associated with anti-TFDP1 antibody
 Disease Name  Pubmed Publications
 Carcinoma, Hepatocellular Antibodies  >6 publications with TFDP1 and Carcinoma, Hepatocellular
 Cell Transformation, Neoplastic Antibodies  >6 publications with TFDP1 and Cell Transformation, Neoplastic
 Carcinoma, Squamous Cell Antibodies  >5 publications with TFDP1 and Carcinoma, Squamous Cell
 Breast Neoplasms Antibodies  >5 publications with TFDP1 and Breast Neoplasms
 Liver Neoplasms Antibodies  >4 publications with TFDP1 and Liver Neoplasms
 Liver Diseases Antibodies  >4 publications with TFDP1 and Liver Diseases
 Nervous System Diseases Antibodies  >4 publications with TFDP1 and Nervous System Diseases
 Neoplasms, Experimental Antibodies  >4 publications with TFDP1 and Neoplasms, Experimental
 Skin Neoplasms Antibodies  >3 publications with TFDP1 and Skin Neoplasms
 Lung Neoplasms Antibodies  >3 publications with TFDP1 and Lung Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >14 publications with TFDP1 and Blood
 Liver Antibodies  >7 publications with TFDP1 and Liver
 Brain Antibodies  >7 publications with TFDP1 and Brain
 Skin Antibodies  >6 publications with TFDP1 and Skin
 Embryonic Tissue Antibodies  >5 publications with TFDP1 and Embryonic Tissue
 Eye Antibodies  >4 publications with TFDP1 and Eye
 Lung Antibodies  >4 publications with TFDP1 and Lung
 Bone Antibodies  >4 publications with TFDP1 and Bone
 Nerve Antibodies  >3 publications with TFDP1 and Nerve
 Lymph Node Antibodies  >2 publications with TFDP1 and Lymph Node
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