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anti-TFE3 antibody :: Goat TFE3 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS420221
Western Blot (WB)
Unit / Price
0.1 mg  /  $300 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

TFE3, Polyclonal Antibody

 Also Known As   

Goat anti-TFE3 Antibody

 Product Synonym Names    TFE3; transcription factor binding to IGHM enhancer 3; Transcription factor for IgH enhancer; RCCP2; TFEA; bHLHe33; OTTHUMP00000024272; Renal cell carcinoma, papillary; Transcription factor for IgH enhancer; transcription factor E family, member A; transc; TFE3 antibody; transcription factor binding to IGHM enhancer 3 antibody; Transcription factor for IgH enhancer antibody; RCCP2 antibody; TFEA antibody; bHLHe33 antibody; OTTHUMP00000024272 antibody; Renal cell carcinoma; papillary antibody; Transcription factor for IgH enhancer antibody; transcription factor E family; member A antibody; transcription factor E3 antibody
 Product Gene Name   

anti-TFE3 antibody

[Similar Products]
 Antibody/Peptide Pairs    TFE3 peptide (MBS426553) is used for blocking the activity of TFE3 antibody (MBS420221)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    SHAAEPARDG VEAS
 OMIM    314310
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 Clonality    Polyclonal
 Host    Goat
 Species Reactivity    Tested: Human; Expected from sequence similarity: Human, Mouse, Dog, Cow
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 Purity/Purification    Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
 Form/Format    Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
 Concentration    100ug specific antibody in 200ul (lot specific)
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 Immunogen    Peptide with sequence SHAAEPARDGVEAS-C, from the N Terminus of the protein sequence according to NP_006512.2.
 Epitope    N Terminus
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-5958
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 Preparation and Storage    Aliquot and store at -20 degree C. Minimize freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of anti-TFE3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-TFE3 antibody   

Peptide ELISA (EIA), Western Blot (WB)

 Application Notes for anti-TFE3 antibody    Peptide ELISA: Antibody detection limit dilution 1: 32000.
Western Blot: Approx 60kDa band observed in lysates of HEK293 (calculated MW of 61.5kDa according to NP_006512.2). Recommended concentration: 1-3ug/ml.
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 Western Blot (WB) of anti-TFE3 antibody    (1ug/ml) staining of HEK293 lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
anti-TFE3 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for TFE3. It may not necessarily be applicable to this product.
 NCBI GI #    8659574
 NCBI GeneID    7030
 NCBI Accession #    NP_006512.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_006521.5 [Other Products]
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 UniProt Secondary Accession #    Q5JU74; Q92757; Q92758; Q99964; A8MZL6 [Other Products]
 UniProt Related Accession #    P19532 [Other Products]
 Molecular Weight    11,363 Da
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 NCBI Official Full Name    transcription factor E3 isoform 1
 NCBI Official Synonym Full Names    transcription factor binding to IGHM enhancer 3
 NCBI Official Symbol    TFE3 [Similar Products]
 NCBI Official Synonym Symbols   
TFEA; RCCP2; RCCX1; bHLHe33
[Similar Products]
 NCBI Protein Information    transcription factor E3
 UniProt Protein Name    Transcription factor E3
 UniProt Synonym Protein Names   
Class E basic helix-loop-helix protein 33; bHLHe33
 Protein Family    Transcription factor
 UniProt Gene Name    TFE3 [Similar Products]
 UniProt Synonym Gene Names    BHLHE33; bHLHe33 [Similar Products]
 UniProt Entry Name    TFE3_HUMAN
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 NCBI Summary for TFE3    This gene encodes a basic helix-loop-helix domain-containing transcription factor that binds MUE3-type E-box sequences in the promoter of genes. The encoded protein promotes the expression of genes downstream of transforming growth factor beta (TGF-beta) signaling. This gene may be involved in chromosomal translocations in renal cell carcinomas and other cancers, resulting in the production of fusion proteins. Translocation partners include PRCC (papillary renal cell carcinoma), NONO (non-POU domain containing, octamer-binding), and ASPSCR1 (alveolar soft part sarcoma chromosome region, candidate 1), among other genes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
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 UniProt Comments for TFE3    TFE3: Transcription factor that specifically recognizes and binds E-box sequences (5'-CANNTG-3'). Efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFEB or MITF. In association with TFEB, activates the expression of CD40L in T-cells, thereby playing a role in T- cell-dependent antibody responses in activated CD4(+) T-cells and thymus-dependent humoral immunity. Specifically recognizes the MUE3 box, a subset of E-boxes, present in the immunoglobulin enhancer. It also binds very well to a USF/MLTF site. A chromosomal aberration involving TFE3 is found in patients with alveolar soft part sarcoma. Translocation t(X;17)(p11;q25) with ASPSCR1 forms a ASPSCR1-TFE3 fusion protein. Chromosomal aberrations involving TFE3 are found in patients with papillary renal cell carcinoma. Translocation t(X;1)(p11.2;q21.2) with PRCC; translocation t(X;1)(p11.2;p34) with PSF; inversion inv(X)(p11.2;q12) that fuses NONO to TFE3. Belongs to the MiT/TFE family.

Protein type: DNA-binding; Oncoprotein; Transcription factor

Chromosomal Location of Human Ortholog: Xp11.22

Cellular Component: cytoplasm; nucleoplasm; nucleus

Molecular Function: protein dimerization activity; transcription factor activity

Biological Process: adaptive immune response; humoral immune response; positive regulation of cell adhesion; positive regulation of transcription from RNA polymerase II promoter; regulation of osteoclast differentiation; transcription from RNA polymerase II promoter

Disease: Renal Cell Carcinoma, Xp11-associated
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 Research Articles on TFE3    1. validates the utility of TFE3 break-apart fluorescence in situ hybridization on formalin-fixed paraffin-embedded tissue sections for diagnosis and confirmation of Xp11.2 translocation RCCs and alveolar soft part sarcoma
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-TFE3 antibodyPathways associated with anti-TFE3 antibody
 Reference Product  PubMed Publications
 PRCC antibody  >51 publications with TFE3 and PRCC
 ASPSCR1 antibody  >48 publications with TFE3 and ASPSCR1
 FLCN antibody  >9 publications with TFE3 and FLCN
 SMAD3 antibody  >7 publications with TFE3 and SMAD3
 SMAD4 antibody  >5 publications with TFE3 and SMAD4
 TYRP1 antibody  >3 publications with TFE3 and TYRP1
 E2F3 antibody  >3 publications with TFE3 and E2F3
 COL1A2 antibody  >2 publications with TFE3 and COL1A2
 SMAD2 antibody  >2 publications with TFE3 and SMAD2
 Products by Pathway  Pathway Diagram
 E2F Transcription Factor Network Pathway antibodies  E2F Transcription Factor Network Pathway Diagram
 Regulation Of Nuclear SMAD2/3 Signaling Pathway antibodies  Regulation Of Nuclear SMAD2/3 Signaling Pathway Diagram
 TGF Beta Signaling Pathway antibodies  TGF Beta Signaling Pathway Diagram
 Transcriptional Misregulation In Cancer Pathway antibodies  Transcriptional Misregulation In Cancer Pathway Diagram
 Transcriptional Misregulation In Cancer Pathway antibodies  Transcriptional Misregulation In Cancer Pathway Diagram
Diseases associated with anti-TFE3 antibodyOrgans/Tissues associated with anti-TFE3 antibody
 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >251 publications with TFE3 and Carcinoma
 Carcinoma, Renal Cell Antibodies  >239 publications with TFE3 and Carcinoma, Renal Cell
 Kidney Diseases Antibodies  >214 publications with TFE3 and Kidney Diseases
 Necrosis Antibodies  >23 publications with TFE3 and Necrosis
 Pain Antibodies  >14 publications with TFE3 and Pain
 Liver Diseases Antibodies  >11 publications with TFE3 and Liver Diseases
 Cardiovascular Diseases Antibodies  >10 publications with TFE3 and Cardiovascular Diseases
 Hemorrhage Antibodies  >9 publications with TFE3 and Hemorrhage
 Neoplasms, Experimental Antibodies  >8 publications with TFE3 and Neoplasms, Experimental
 Diabetes Mellitus Antibodies  >8 publications with TFE3 and Diabetes Mellitus
 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >228 publications with TFE3 and Kidney
 Muscle Antibodies  >54 publications with TFE3 and Muscle
 Lung Antibodies  >42 publications with TFE3 and Lung
 Vascular Antibodies  >38 publications with TFE3 and Vascular
 Lymph Node Antibodies  >29 publications with TFE3 and Lymph Node
 Lymph Antibodies  >29 publications with TFE3 and Lymph
 Blood Antibodies  >29 publications with TFE3 and Blood
 Bone Antibodies  >27 publications with TFE3 and Bone
 Liver Antibodies  >26 publications with TFE3 and Liver
 Brain Antibodies  >17 publications with TFE3 and Brain
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